ELAVL1 and MIRLET7B

Number of citations of the paper that reports this interaction (PubMedID 24326307)
39

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		ELAVL1	MIRLET7B
Description		ELAV like RNA binding protein 1	microRNA let-7b
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Sarcoplasm Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity LncRNA Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	LncRNA-mediated Post-transcriptional Gene Silencing Protein Import Into Nucleus Cell Population Proliferation Response To Glucose Positive Regulation Of Autophagy Post-transcriptional Gene Silencing Positive Regulation Of Superoxide Anion Generation Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Autophagosome Size MRNA Stabilization Protein Homooligomerization Negative Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance	Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Reactive Oxygen Species MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of ERK1 And ERK2 Cascade Antibacterial Innate Immune Response Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Macrophage Apoptotic Process
Pathways		HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS
Interacting Genes		44 interacting genes: AKT1 ANP32A ANP32B APOE C12orf75 CARM1 CEBPA CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL6 IL7R KPNA1 KPNB1 LINC00460 LINC00632 MIRLET7B MIRLET7I NEIL3 NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SHANK3 SREK1 TNPO1 TNPO2 TRIM21 VCP VEGFA	99 interacting genes: ADARB1 AGO2 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CELF1 CPSF1 CPSF6 CPSF7 CRTAP DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 ELAVL1 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 P3H1 PDCD11 PGAM5 PLOD1 PTBP1 PUF60 PUM2 PURA QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RBM4B RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		1994	406884
HPRD ID		16025
Ensembl ID		ENSG00000066044	ENSG00000284520
Uniprot IDs		Q15717
PDB IDs		3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Import Signal Receptor Activity Regulation Of Signal Transduction Regulation Of Platelet Activation Nuclear Localization Sequence Binding Regulation Of Macromolecule Metabolic Process Stress Granule Disassembly Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Blood Coagulation Positive Regulation Of Catabolic Process Intracellular Signaling Cassette Regulation Of Fat Cell Differentiation Regulation Of Hemostasis Regulation Of Wound Healing Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Response To Wounding Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Splicing Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Nucleus Ribonucleoprotein Complex Nucleoplasm MiRNA Binding Cytoplasmic Stress Granule MRNA Splicing, Via Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex RNA Splicing, Via Transesterification Reactions Regulation Of Translation Regulation Of MRNA Processing Catalytic Step 2 Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process Spliceosomal Complex Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Regulation Of RNA Stability Regulation Of MRNA Stability RNA Stabilization Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Translation MRNA Stabilization Regulation Of Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Nucleolus MRNA Cleavage And Polyadenylation Specificity Factor Complex Double-stranded RNA Binding Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Gene Expression
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