TOM1 and PTBP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TOM1	PTBP2
Description		target of myb1 membrane trafficking protein	polypyrimidine tract binding protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Extracellular Exosome	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Clathrin Binding Polyubiquitin Modification-dependent Protein Binding Clathrin Heavy Chain Binding Phosphatidylinositol Binding Ubiquitin Binding Myosin VI Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Endocytosis Signal Transduction Protein Transport Endosomal Transport Substrate Localization To Autophagosome Autophagosome-lysosome Fusion Positive Regulation Of Autophagosome Maturation Regulation Of Endosome Organization	MRNA Splice Site Recognition MRNA Processing RNA Splicing Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068) HDL cholesterol ( 29404214) High density lipoprotein cholesterol levels ( 31217584) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hippocampal volume in mild cognitive impairment ( 29274321) Inflammatory bowel disease ( 28067908) Low density lipoprotein cholesterol levels ( 32154731) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Total cholesterol levels ( 28334899) Triglyceride levels ( 34074324) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 20935630 28892062 28448500 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Daytime nap ( 33568662) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 22688191 19571811) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 30944420 32239398) Waist circumference ( 25673412)
Interacting Genes		25 interacting genes: APP BBS4 BBS5 BBS9 CLTC DAZAP2 EEA1 HACL2 LITAF LRRC20 NAA11 NEDD4 OGT PILRA PTBP2 RPS27 SMURF1 SNCA SSBP2 TOLLIP UBC UBE2D1 WWP2 ZFYVE16 ZNF512B	26 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GOLGA2 HNRNPAB HNRNPC HNRNPD ISY1 KHDRBS1 KHDRBS3 KHSRP LINC00624 MAGOH MATR3 OGT PCBP2 PCBP3 PRDX4 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA SRPK2 TOM1
Entrez ID		10043	58155
HPRD ID		05265	12233
Ensembl ID		ENSG00000100284	ENSG00000117569
Uniprot IDs		B3KUF5 O60784	A0A6Q8PFE6 A0A7I2RVZ4 B4DSS8 B4DSU5 Q9UKA9
PDB IDs		1ELK 1WRD 2N2N 2N9D 6J56	2CQ1 2MJU 4CQ1
Enriched GO Terms of Interacting Partners?		BBSome Protein-containing Complex Protein Localization To Vacuole Cytoplasm Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Localization To Organelle Centriolar Satellite Establishment Of Localization In Cell Protein Targeting To Vacuole Ciliary Membrane Protein Localization To Lysosome Potassium Channel Inhibitor Activity Establishment Of Protein Localization To Vacuole Cytosol Intracellular Protein Localization Protein Transport Receptor Internalization Modification-dependent Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane 1-phosphatidylinositol Binding Early Endosome Membrane Intracellular Transport Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Regulation Of Neurotransmitter Uptake Protein Serine/threonine Kinase Binding Cellular Response To Copper Ion Establishment Of Melanosome Localization Pericentriolar Material Melanosome Localization Establishment Of Protein Localization Melanosome Transport Pigment Granule Transport Establishment Of Vesicle Localization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity WW Domain Binding Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Regulation Of Monoatomic Cation Transmembrane Transport Pigment Granule Localization Negative Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion	Regulation Of MRNA Metabolic Process Nucleic Acid Binding RNA Binding MRNA Metabolic Process MRNA Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Splicing RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing RNA Processing RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process MiRNA Binding Negative Regulation Of RNA Catabolic Process Nucleic Acid Metabolic Process Negative Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of Catabolic Process Ribonucleoprotein Complex Nucleus Positive Regulation Of Translation RNA Stabilization Regulation Of Translation Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Gene Expression Regulation Of Gene Expression Circadian Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR AU-rich Region Binding Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Nucleoplasm Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Metabolic Process Non-canonical Inflammasome Complex Assembly Negative Regulation Of Gene Expression
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