TOM1 and EEA1

Number of citations of the paper that reports this interaction (PMID 14613930)
6

Data Source:
HPRD (in vitro)

		TOM1	EEA1
Gene Name		target of myb1 (chicken)	early endosome antigen 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Extracellular Vesicular Exosome	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Cytoplasmic Vesicle Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Clathrin Binding	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Endocytosis Protein Transport Endosomal Transport	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Early Endosome To Late Endosome Transport
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs			Inositol 1,3-Bisphosphate
Diseases
GWAS
Protein-Protein Interactions		14 interactors: APP CLTC EEA1 ILVBL MYO6 NEDD4 PTBP2 RPS27 SSBP2 TOLLIP UBC UBE2D1 ZFYVE16 ZNF512B	11 interactors: IGF1R MAPK14 RAB22A RAB5A RAB5B RAB5C STX12 STX6 TOM1 USO1 ZFYVE16
Entrez ID		10043	8411
HPRD ID		05265	05460
Ensembl ID		ENSG00000100284	ENSG00000102189
Uniprot IDs		B3KUF5 O60784	Q15075
PDB IDs		1ELK 1WRD	1HYI 1HYJ 1JOC 3MJH
Enriched GO Terms of Interacting Partners?		Intracellular Transport Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Establishment Of Localization In Cell Protein Targeting To Lysosome Endocytosis Protein Localization To Lysosome Regulation Of Nitrogen Compound Metabolic Process Cellular Protein Localization Protein Targeting To Vacuole Protein Targeting Membrane Organization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Establishment Of Protein Localization To Vacuole Intracellular Protein Transport Protein Polyubiquitination Synapse Organization Protein Localization To Organelle Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Endosomal Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus Receptor Internalization Regulation Of Cell Cycle Phase Transition Lysosomal Transport Regulation Of Transcription From RNA Polymerase II Promoter Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Protein Localization Neuromuscular Junction Development Regulation Of Gene Expression Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cytoplasmic Transport Immune Response Positive Regulation Of Proteolysis Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Synaptic Vesicle To Endosome Fusion Transmission Of Virus Development Involved In Symbiotic Interaction TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway	Intracellular Protein Transport Endosomal Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Rab Protein Signal Transduction Vesicle-mediated Transport Ras Protein Signal Transduction Cellular Localization Endosome Organization Regulation Of Endocytosis Vesicle Fusion Vesicle Organization Plasma Membrane To Endosome Transport Small GTPase Mediated Signal Transduction Organelle Fusion Cytoplasmic Transport Regulation Of Vesicle-mediated Transport Membrane Fusion Transport Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization P38MAPK Cascade Inactivation Of MAPKK Activity Vesicle Docking Membrane Docking Endomembrane System Organization Regulation Of Vesicle Size Golgi Vesicle Docking Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Brown Fat Cell Differentiation Endocytosis Golgi Ribbon Formation Signal Transduction Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Vesicle Fusion With Golgi Apparatus Positive Regulation Of Hormone Biosynthetic Process 3'-UTR-mediated MRNA Stabilization Stress-induced Premature Senescence Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Targeting To Lysosome
Tagcloud ?		109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 myo6 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 ubbd ubbddelta weakened	appl1 characterised colocalisation colocalises compartments employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst
Tagcloud (Difference) ?		109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 myo6 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 ubbd ubbddelta weakened	appl1 characterised colocalisation colocalises compartments employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst
Tagcloud (Intersection) ?