TOM1 and LRRC20

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TOM1	LRRC20
Description		target of myb1 membrane trafficking protein	leucine rich repeat containing 20
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Clathrin Binding Polyubiquitin Modification-dependent Protein Binding Clathrin Heavy Chain Binding Phosphatidylinositol Binding Ubiquitin Binding Myosin VI Binding	Protein Binding
	Biological Process	Endocytosis Signal Transduction Protein Transport Endosomal Transport Substrate Localization To Autophagosome Autophagosome-lysosome Fusion Positive Regulation Of Autophagosome Maturation Regulation Of Endosome Organization
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068) HDL cholesterol ( 29404214) High density lipoprotein cholesterol levels ( 31217584) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hippocampal volume in mild cognitive impairment ( 29274321) Inflammatory bowel disease ( 28067908) Low density lipoprotein cholesterol levels ( 32154731) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Total cholesterol levels ( 28334899) Triglyceride levels ( 34074324) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Brain connectivity ( 23471985) Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		25 interacting genes: APP BBS4 BBS5 BBS9 CLTC DAZAP2 EEA1 HACL2 LITAF LRRC20 NAA11 NEDD4 OGT PILRA PTBP2 RPS27 SMURF1 SNCA SSBP2 TOLLIP UBC UBE2D1 WWP2 ZFYVE16 ZNF512B	3 interacting genes: FBXO7 TOM1 ZBED1
Entrez ID		10043	55222
HPRD ID		05265	14314
Ensembl ID		ENSG00000100284	ENSG00000172731
Uniprot IDs		B3KUF5 O60784	A0A0A0MS58 Q8TCA0
PDB IDs		1ELK 1WRD 2N2N 2N9D 6J56
Enriched GO Terms of Interacting Partners?		BBSome Protein-containing Complex Protein Localization To Vacuole Cytoplasm Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Localization To Organelle Centriolar Satellite Establishment Of Localization In Cell Protein Targeting To Vacuole Ciliary Membrane Protein Localization To Lysosome Potassium Channel Inhibitor Activity Establishment Of Protein Localization To Vacuole Cytosol Intracellular Protein Localization Protein Transport Receptor Internalization Modification-dependent Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane 1-phosphatidylinositol Binding Early Endosome Membrane Intracellular Transport Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Regulation Of Neurotransmitter Uptake Protein Serine/threonine Kinase Binding Cellular Response To Copper Ion Establishment Of Melanosome Localization Pericentriolar Material Melanosome Localization Establishment Of Protein Localization Melanosome Transport Pigment Granule Transport Establishment Of Vesicle Localization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity WW Domain Binding Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Regulation Of Monoatomic Cation Transmembrane Transport Pigment Granule Localization Negative Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion	Protein Autosumoylation Positive Regulation Of Macroautophagy Ubiquitin Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Autophagy Regulation Of Macroautophagy Myosin VI Binding Lewy Body Core Regulation Of Endosome Organization Substrate Localization To Autophagosome Regulation Of Autophagy Positive Regulation Of Autophagosome Maturation Clathrin Heavy Chain Binding SUMO Ligase Activity Host-mediated Suppression Of Viral Genome Replication Autophagosome-lysosome Fusion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of Catabolic Process Phosphatidylinositol-5-phosphate Binding SUMO Transferase Activity Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Protein Modification By Small Protein Conjugation Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion Clathrin Binding Positive Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Post-translational Protein Modification
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