PPFIA1 and DYNC1I2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPFIA1	DYNC1I2
Description		PPFI scaffold protein A1	dynein cytoplasmic 1 intermediate chain 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Cell Cortex Axon Dendrite Protein-containing Complex Presynaptic Active Zone Spine Apparatus Schaffer Collateral - CA1 Synapse	Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Vesicle
	Molecular Function	Protein Binding	Microtubule Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Cortical Microtubule Organization Synapse Organization Negative Regulation Of Stress Fiber Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Protein Localization To Plasma Membrane	Microtubule-based Movement Transport Along Microtubule Positive Regulation Of Intracellular Transport
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Lymphocyte count ( 32888494)	Hippocampal volume ( 25625606) Metabolite levels ( 23823483) Refractive error ( 32231278) Weight ( 28552196)
Interacting Genes		32 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 CNKSR1 DRC4 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS TNNT1 TXLNA USP7 YWHAG	8 interacting genes: CCDC136 DCTN1 DYNLRB1 DYNLT1 DYNLT3 NECAB2 PNN PPFIA1
Entrez ID		8500	1781
HPRD ID		11451	04512
Ensembl ID		ENSG00000131626	ENSG00000077380
Uniprot IDs		A0AAG2UWZ2 B3KVS8 Q13136	A0A140VKE9 B4DPZ3 Q13409
PDB IDs		1N7F	5JPW 6F1T 6F1U 6F1Z 6F38 6F3A 7Z8F 7Z8I 7Z8J 7Z8K 8PQW 8PQZ 8PR0 8PR1 8PR2 8PR3 8PTK
Enriched GO Terms of Interacting Partners?		Synapse Organization Presynaptic Active Zone Cell Junction Organization Maintenance Of Synapse Structure Presynaptic Active Zone Organization Presynaptic Active Zone Cytoplasmic Component Cell Junction Maintenance Transmembrane Receptor Protein Tyrosine Phosphatase Activity Synapse Presynaptic Membrane Cellular Component Maintenance Synaptic Membrane Adhesion Gamma-tubulin Binding Protein Tyrosine Phosphatase Activity Modulation Of Chemical Synaptic Transmission Cell Projection Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Presynapse Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Postsynaptic Density Cytosol Phosphoprotein Phosphatase Activity Regulation Of Dendritic Spine Development Growth Cone Maintenance Of Postsynaptic Specialization Structure Cytoplasm Centrosome Inhibitory Synapse Protein Phosphatase Type 2A Complex Regulation Of Postsynaptic Density Assembly Protein Phosphatase Activator Activity Heparan Sulfate Proteoglycan Binding Protein Dephosphorylation Presynapse Organization Glutamatergic Synapse Postsynaptic Density Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Postsynaptic Specialization Organization Regulation Of Axon Regeneration Negative Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Neuron Projection Regeneration Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Plasma Membrane Raft Distribution Chondroitin Sulfate Proteoglycan Binding Slow-twitch Skeletal Muscle Fiber Contraction Structural Constituent Of Presynapse	Dynein Complex Cytoplasmic Dynein Complex Dynein Intermediate Chain Binding Microtubule Microtubule-based Movement Microtubule-based Process Establishment Of Mitotic Spindle Orientation Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Regulation Of Cellular Localization Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Establishment Of Spindle Localization Spindle Localization Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Bone Mineralization Involved In Bone Maturation Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Axon Mitotic Spindle Astral Microtubule Spine Apparatus Type 5 Metabotropic Glutamate Receptor Binding Hemi-methylated DNA-binding
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