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PPFIA1 and CAST
Number of citations of the paper that reports this interaction (PubMedID
12923177
)
0
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
PPFIA1
CAST
Description
PPFI scaffold protein A1
calpastatin
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Focal Adhesion
Cell Cortex
Axon
Dendrite
Protein-containing Complex
Presynaptic Active Zone
Spine Apparatus
Schaffer Collateral - CA1 Synapse
Cytoplasm
Endoplasmic Reticulum
Cytosol
Membrane
Molecular Function
Protein Binding
RNA Binding
Endopeptidase Inhibitor Activity
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity
Peptidase Inhibitor Activity
Cadherin Binding
Biological Process
Cell-matrix Adhesion
Signal Transduction
Cortical Microtubule Organization
Synapse Organization
Negative Regulation Of Stress Fiber Assembly
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Negative Regulation Of Protein Localization To Plasma Membrane
Presynaptic Active Zone Organization
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Receptor-type tyrosine-protein phosphatases
Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Calcium
Artenimol
Diseases
GWAS
Coronary artery disease (
29212778
)
Lymphocyte count (
32888494
)
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Alcohol dependence (
19581569
)
Appendicular lean mass (
33097823
)
Body mass index (
26426971
29381148
)
Fish- and plant-related diet (
32066663
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Interacting Genes
32 interacting genes:
AGTPBP1
CAGE1
CAST
CCNH
CDK18
CEP70
CNKSR1
DRC4
DTNB
DYNC1I2
ELOA
ERC1
ERC2
FAM161A
GIT1
MBIP
NCOA2
NDN
PPFIA2
PPFIA3
PPFIBP1
PPFIBP2
PPP2R5A
PPP2R5D
PTPRC
PTPRD
PTPRF
PTPRS
TNNT1
TXLNA
USP7
YWHAG
11 interacting genes:
CAPN1
CAPNS1
CASP1
CASP3
CASP7
HTRA1
PPFIA1
PPFIA2
PPFIA3
PPFIA4
SUMO2
Entrez ID
8500
831
HPRD ID
11451
00233
Ensembl ID
ENSG00000131626
ENSG00000310517
Uniprot IDs
A0AAG2UWZ2
B3KVS8
Q13136
A0A6Q8PH20
B7Z6N0
E9PCH5
E9PDE4
P20810
Q59HE3
Q86YM9
PDB IDs
1N7F
Enriched GO Terms of Interacting Partners
?
Synapse Organization
Presynaptic Active Zone
Cell Junction Organization
Maintenance Of Synapse Structure
Presynaptic Active Zone Organization
Presynaptic Active Zone Cytoplasmic Component
Cell Junction Maintenance
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Synapse
Presynaptic Membrane
Cellular Component Maintenance
Synaptic Membrane Adhesion
Gamma-tubulin Binding
Protein Tyrosine Phosphatase Activity
Modulation Of Chemical Synaptic Transmission
Cell Projection
Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway
Presynapse
Structural Constituent Of Presynaptic Active Zone
Maintenance Of Presynaptic Active Zone Structure
Postsynaptic Density
Cytosol
Phosphoprotein Phosphatase Activity
Regulation Of Dendritic Spine Development
Growth Cone
Maintenance Of Postsynaptic Specialization Structure
Cytoplasm
Centrosome
Inhibitory Synapse
Protein Phosphatase Type 2A Complex
Regulation Of Postsynaptic Density Assembly
Protein Phosphatase Activator Activity
Heparan Sulfate Proteoglycan Binding
Protein Dephosphorylation
Presynapse Organization
Glutamatergic Synapse
Postsynaptic Density Organization
Regulation Of Postsynaptic Specialization Assembly
Regulation Of Excitatory Synapse Assembly
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Postsynaptic Specialization Organization
Regulation Of Axon Regeneration
Negative Regulation Of Receptor Signaling Pathway Via STAT
Regulation Of Neuron Projection Regeneration
Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity
Plasma Membrane Raft Distribution
Chondroitin Sulfate Proteoglycan Binding
Slow-twitch Skeletal Muscle Fiber Contraction
Structural Constituent Of Presynapse
Presynaptic Active Zone
Protein Poly-ADP-ribosylation
Calpain Complex
Cysteine-type Peptidase Activity
Pyroptotic Inflammatory Response
Cellular Response To Staurosporine
Peptidase Activity
Cysteine-type Endopeptidase Activity
Synapse Organization
Calcium-dependent Cysteine-type Endopeptidase Activity
Fibroblast Apoptotic Process
Proteolysis
Interleukin-18-mediated Signaling Pathway
Cytosol
Aspartic-type Endopeptidase Activity
Execution Phase Of Apoptosis
Plasma Membrane Repair
Cell Junction Organization
Protein Processing
Regulation Of Macroautophagy
Cellular Response To Alkaloid
Glutamatergic Synapse
Cellular Response To Osmotic Stress
Leukocyte Apoptotic Process
Ceramide Biosynthetic Process
Structural Constituent Of Presynapse
Epididymosome
Protein Metabolic Process
Cytoplasm
Protein Maturation
Response To Lipopolysaccharide
Positive Regulation Of Neuron Apoptotic Process
Striated Muscle Cell Differentiation
Response To Osmotic Stress
Response To Molecule Of Bacterial Origin
AIM2 Inflammasome Complex Assembly
Protease Inhibitor Complex
Phospholipase A2 Activator Activity
Regulation Of Autophagy
Ceramide Metabolic Process
Post-translational Protein Modification
Endopeptidase Activity
Response To Alkaloid
Sphingolipid Biosynthetic Process
AIM2 Inflammasome Complex
IPAF Inflammasome Complex
Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Structural Constituent Of Postsynaptic Density
Hydrolase Activity
Cell Death
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Tagcloud (Intersection)
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