PPFIA1 and CAST

Number of citations of the paper that reports this interaction (PMID 12923177)
33

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PPFIA1	CAST
Gene Name		protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	calpastatin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone	Cytoplasm Cytosol Membrane
	Molecular Function	Signal Transducer Activity Protein Binding	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			Calcium
Diseases
GWAS			Alcohol dependence ( 19581569)
Protein-Protein Interactions		25 interactors: AGTPBP1 CAST CCNH CEP70 DTNB ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5D PTPRC PTPRD PTPRF PTPRG PTPRS TNNT1 TXLNA YWHAG	10 interactors: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4
Entrez ID		8500	831
HPRD ID		11451	00233
Ensembl ID		ENSG00000131626	ENSG00000153113
Uniprot IDs		B3KVS8 Q13136	P20810 Q59HE3 Q86YM9
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Dephosphorylation Protein Dephosphorylation Dephosphorylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Signaling Cell Communication Cell Cycle Phase Transition Nervous System Development G2/M Transition Of Mitotic Cell Cycle Glutamate Secretion Cellular Protein Modification Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase I Promoter Generation Of Neurons Transcription From RNA Polymerase I Promoter Neurogenesis Cell Adhesion Signal Transduction Negative Regulation Of Protein Kinase Activity Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Negative Regulation Of Kinase Activity Acid Secretion Mitotic Cell Cycle Phase Transition Cellular Response To Stimulus Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transferase Activity Phosphate-containing Compound Metabolic Process Dicarboxylic Acid Transport DNA-templated Transcription, Elongation Cellular Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Neuron Differentiation C-terminal Protein Deglutamylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Response To Stimulus Neurotransmitter Secretion Cell Surface Receptor Signaling Pathway Developmental Process Histone Acetylation Negative Regulation Of Catalytic Activity Cerebellum Development Regulation Of Kinase Activity Negative Regulation Of Phosphorylation	Glutamate Secretion Acid Secretion Dicarboxylic Acid Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Amino Acid Transport Neurotransmitter Transport Execution Phase Of Apoptosis Carboxylic Acid Transport Organic Acid Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extracellular Matrix Disassembly Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Organic Anion Transport Positive Regulation Of Peptidase Activity Secretion By Cell Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Synaptic Transmission Regulation Of Cysteine-type Endopeptidase Activity Secretion Anion Transport Protein Processing Positive Regulation Of Proteolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Signaling Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Dentinogenesis Positive Regulation Of Cell Death Cell-matrix Adhesion Regulation Of Proteolysis Regulation Of Cell Proliferation Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Signaling Intrinsic Apoptotic Signaling Pathway Cell Communication Glial Cell Apoptotic Process
Tagcloud ?		11q13 aberrations acgh aiming amplicon apart band breakpoints candidates ccnd1 chosen chr comprised copies cttn distinguish fadd gain homogeneously laryngeal microarray oncogene oncogenes oraov1 q13 rearrangements reinvestigated sevenfold ways	absent antiserum b1 cardiomyocyte discs doubt dreifuss dystrophy edmd emerin emery explanation intercalated intranuclear lamin lamina lap1 lap2 lbr libraries localize mabs muscular myocyte nuclei phage recognize rim spots
Tagcloud (Difference) ?		11q13 aberrations acgh aiming amplicon apart band breakpoints candidates ccnd1 chosen chr comprised copies cttn distinguish fadd gain homogeneously laryngeal microarray oncogene oncogenes oraov1 q13 rearrangements reinvestigated sevenfold ways	absent antiserum b1 cardiomyocyte discs doubt dreifuss dystrophy edmd emerin emery explanation intercalated intranuclear lamin lamina lap1 lap2 lbr libraries localize mabs muscular myocyte nuclei phage recognize rim spots
Tagcloud (Intersection) ?