PPFIA1 and PTPRF

Number of citations of the paper that reports this interaction (PMID 7796809)
60

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PPFIA1	PTPRF
Gene Name		protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	protein tyrosine phosphatase, receptor type, F
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone	Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Protein Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Protein Complex Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane	Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Receptor Binding
Pathways		Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728)
Protein-Protein Interactions		25 interactors: AGTPBP1 CAST CCNH CEP70 DTNB ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5D PTPRC PTPRD PTPRF PTPRG PTPRS TNNT1 TXLNA YWHAG	23 interactors: BCAR1 CAV1 CDH1 CTNNB1 FRS2 FYN GALNT1 INSR IRS1 IRS2 JUP LCK NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD RET SKIL TRIO ZNF512B
Entrez ID		8500	5792
HPRD ID		11451	01552
Ensembl ID		ENSG00000131626	ENSG00000142949
Uniprot IDs		B3KVS8 Q13136	P10586
PDB IDs			1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Dephosphorylation Protein Dephosphorylation Dephosphorylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Signaling Cell Communication Cell Cycle Phase Transition Nervous System Development G2/M Transition Of Mitotic Cell Cycle Glutamate Secretion Cellular Protein Modification Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase I Promoter Generation Of Neurons Transcription From RNA Polymerase I Promoter Neurogenesis Cell Adhesion Signal Transduction Negative Regulation Of Protein Kinase Activity Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Negative Regulation Of Kinase Activity Acid Secretion Mitotic Cell Cycle Phase Transition Cellular Response To Stimulus Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transferase Activity Phosphate-containing Compound Metabolic Process Dicarboxylic Acid Transport DNA-templated Transcription, Elongation Cellular Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Neuron Differentiation C-terminal Protein Deglutamylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Response To Stimulus Neurotransmitter Secretion Cell Surface Receptor Signaling Pathway Developmental Process Histone Acetylation Negative Regulation Of Catalytic Activity Cerebellum Development Regulation Of Kinase Activity Negative Regulation Of Phosphorylation	Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Growth Factor Stimulus Response To Organonitrogen Compound Response To Growth Factor Cellular Response To Organic Substance Response To Peptide Hormone Response To Peptide Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Hormone Stimulus Cell Adhesion Insulin Receptor Signaling Pathway Response To Hormone Cellular Response To Indole-3-methanol Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Insulin Stimulus Signaling Regulation Of Cell Death System Development Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Communication Locomotion Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cellular Component Movement Phosphatidylinositol-mediated Signaling Positive Regulation Of Glycogen Biosynthetic Process Response To Insulin Multicellular Organismal Development Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cellular Component Organization Anatomical Structure Development Organ Development Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Signal Transduction
Tagcloud ?		11q13 aberrations acgh aiming amplicon apart band breakpoints candidates ccnd1 chosen chr comprised copies cttn distinguish fadd gain homogeneously laryngeal microarray oncogene oncogenes oraov1 q13 rearrangements reinvestigated sevenfold ways	1r abrogated blue bombesin castration cleavage clonogenic conditioned contributions docetaxel endpoints engineered lncap medium ne neuroendocrine neuropeptides neurotensin paracrine parp pc3 phenomenon principle pthrp secretions talk thoroughly trypan twofold
Tagcloud (Difference) ?		11q13 aberrations acgh aiming amplicon apart band breakpoints candidates ccnd1 chosen chr comprised copies cttn distinguish fadd gain homogeneously laryngeal microarray oncogene oncogenes oraov1 q13 rearrangements reinvestigated sevenfold ways	1r abrogated blue bombesin castration cleavage clonogenic conditioned contributions docetaxel endpoints engineered lncap medium ne neuroendocrine neuropeptides neurotensin paracrine parp pc3 phenomenon principle pthrp secretions talk thoroughly trypan twofold
Tagcloud (Intersection) ?