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IFNAR1 and IFNAR2
Number of citations of the paper that reports this interaction (PubMedID
26008745
)
94
Data Source:
BioGRID
(imaging technique, affinity chromatography technology)
HPRD
(in vitro)
IFNAR1
IFNAR2
Description
interferon alpha and beta receptor subunit 1
interferon alpha and beta receptor subunit 2
Image
GO Annotations
Cellular Component
Lysosome
Endosome
Late Endosome
Plasma Membrane
Membrane
Receptor Complex
Extracellular Region
Extracellular Space
Plasma Membrane
Membrane
Receptor Complex
Molecular Function
Interferon Receptor Activity
Type I Interferon Receptor Activity
Protein Binding
JAK Pathway Signal Transduction Adaptor Activity
Cytokine Binding
Type I Interferon Binding
Type I Interferon Receptor Activity
Protein Binding
JAK Pathway Signal Transduction Adaptor Activity
Protein Kinase Binding
Cytokine Binding
Type I Interferon Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Response To Virus
Positive Regulation Of Metabolic Process
Cytokine-mediated Signaling Pathway
Response To Lipopolysaccharide
Cellular Response To Interferon-alpha
Cellular Response To Interferon-beta
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Type I Interferon-mediated Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Cellular Respiration
Regulation Of Transcription By RNA Polymerase II
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Response To Virus
Response To Interferon-alpha
Response To Interferon-beta
Cellular Response To Interferon-beta
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Protein Localization To Nucleus
Pathways
Interferon alpha/beta signaling
Regulation of IFNA/IFNB signaling
Regulation of IFNA/IFNB signaling
Potential therapeutics for SARS
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Evasion by RSV of host interferon responses
Drugs
Peginterferon alfa-2a
Interferon alfa-n1
Interferon alfa-n3
Peginterferon alfa-2b
Interferon alfa-2a
Interferon beta-1a
Interferon beta-1b
Interferon alfacon-1
Interferon alfa-2b
Interferon alfa
Human interferon omega-1
Peginterferon beta-1a
Anifrolumab
Human interferon beta
Ropeginterferon alfa-2b
Peginterferon alfa-2a
Interferon alfa-n1
Interferon alfa-n3
Peginterferon alfa-2b
Interferon alfa-2a
Interferon beta-1a
Interferon beta-1b
Interferon alfacon-1
Interferon alfa-2b
Human interferon omega-1
Nylidrin
Ropeginterferon alfa-2b
Diseases
GWAS
Blood protein levels (
30072576
)
Crohn's disease (
23128233
)
Psoriasis (
25903422
)
Attention deficit hyperactivity disorder (
30563984
)
Cerebellum white matter volume (
31530798
)
COVID-19 (
33949668
)
Crohn's disease (
23128233
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Type 2 diabetes (
30130595
)
Interacting Genes
26 interacting genes:
BRCC3
CRKL
FBXW11
IFNA1
IFNA2
IFNAR2
IFNB1
IFNW1
LAPTM4B
LCK
LRPAP1
MAPK1
PIK3R1
PRKACA
PRKD2
PRMT1
PTPN11
PTPN6
PTPRC
RACK1
SOCS1
STAT2
STAT3
TYK2
USP7
ZAP70
15 interacting genes:
IFNA2
IFNA5
IFNA8
IFNAR1
IFNB1
JAK1
PPP1R3B
PRKAR2A
PRKCB
RACK1
STAT1
STAT2
STAT3
TYK2
USP18
Entrez ID
3454
3455
HPRD ID
00126
03850
Ensembl ID
ENSG00000142166
ENSG00000159110
Uniprot IDs
A0A8V8TQK8
A0A994J6F6
P17181
P48551
Q9BUA0
PDB IDs
3S98
3SE3
3SE4
4PO6
8Y31
1N6U
1N6V
2HYM
2KZ1
2LAG
3S8W
3S9D
3SE3
3SE4
Enriched GO Terms of Interacting Partners
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Cytokine-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of Signal Transduction
Type I Interferon-mediated Signaling Pathway
Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Interferon-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway Via STAT
Regulation Of Immune System Process
T Cell Receptor Signaling Pathway
Regulation Of Immune Response
Cytokine Receptor Binding
Regulation Of Hemopoiesis
T Cell Activation
Positive Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of Signaling
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Adhesion
Type I Interferon Receptor Binding
Regulation Of Cytokine Production
Cellular Response To Virus
Positive Regulation Of Signal Transduction
Protein Modification Process
Natural Killer Cell Activation Involved In Immune Response
Antigen Receptor-mediated Signaling Pathway
Leukocyte Activation Involved In Immune Response
Positive Regulation Of Intracellular Signal Transduction
Response To Exogenous DsRNA
Regulation Of Intracellular Signal Transduction
Cell Activation Involved In Immune Response
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Regulation Of Developmental Process
Leukocyte Activation
Response To DsRNA
Positive Regulation Of Immune System Process
B Cell Activation
Regulation Of Multicellular Organismal Process
Immune System Process
Lymphocyte Activation
Natural Killer Cell Activation
Cell Activation
Phosphate-containing Compound Metabolic Process
Negative Regulation Of Cytokine Production
Regulation Of Lymphocyte Differentiation
Positive Regulation Of Cell Adhesion
Negative Regulation Of Gene Expression
Type I Interferon-mediated Signaling Pathway
Interferon-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway Via STAT
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Response To Virus
Cellular Response To Virus
Cytokine-mediated Signaling Pathway
Type I Interferon Receptor Binding
Natural Killer Cell Activation Involved In Immune Response
Defense Response To Virus
Response To Other Organism
Cytokine Receptor Binding
Response To External Biotic Stimulus
Interleukin-9-mediated Signaling Pathway
CCR5 Chemokine Receptor Binding
Response To Exogenous DsRNA
Response To DsRNA
Interleukin-10-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Natural Killer Cell Activation
Adaptive Immune Response
Type II Interferon-mediated Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
B Cell Activation Involved In Immune Response
T Cell Activation Involved In Immune Response
B Cell Activation
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Cellular Response To Interferon-beta
Positive Regulation Of Protein Localization
ISGF3 Complex
Response To Interferon-beta
Immune Response
Lymphocyte Activation Involved In Immune Response
Negative Regulation Of T-helper 2 Cell Cytokine Production
Leukocyte Activation Involved In Immune Response
Defense Response
Regulation Of Protein Localization To Nucleus
Cell Activation Involved In Immune Response
Interleukin-23-mediated Signaling Pathway
Interleukin-11-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Signal Transduction
Regulation Of Immune System Process
Growth Hormone Receptor Binding
Interleukin-15-mediated Signaling Pathway
Type III Interferon-mediated Signaling Pathway
Negative Regulation Of Immune Response
Cytokine Activity
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