IFNAR1 and FBXW11

Number of citations of the paper that reports this interaction (PMID 14532120)
60

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)
HPRD (in vivo, in vitro)

		IFNAR1	FBXW11
Gene Name		interferon (alpha, beta and omega) receptor 1	F-box and WD repeat domain containing 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Ubiquitin Ligase Complex Nucleus Centrosome Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production T Cell Activation Type I Interferon Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Protein Dephosphorylation Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways		Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Antigen processing: Ubiquitination & Proteasome degradation Activation of NF-kappaB in B cells G2/M Transition Class I MHC mediated antigen processing & presentation Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Adaptive Immune System
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 23128233)	Height ( 20881960 23563607)
Protein-Protein Interactions		21 interactors: CRKL FBXW11 GNB2L1 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC STAT2 STAT3 TYK2 ZAP70	14 interactors: AMER1 BHLHE40 BTRC CDC25A CUL1 GLI2 IFNAR1 KDR NFKB1 NFKBIA PRLR TRIM21 UBE2D3 WEE1
Entrez ID		3454	23291
HPRD ID		00126	07294
Ensembl ID		ENSG00000142166	ENSG00000072803
Uniprot IDs		B4DNT3 P17181	B4DH70 Q9UKB1
PDB IDs		3S98 3SE3 3SE4
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Defense Response Innate Immune Response Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Organic Substance Response To Type I Interferon Regulation Of Cellular Ketone Metabolic Process Response To Cytokine Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell Adhesion Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of T Cell Activation Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Activation Immune System Development Cellular Response To Stimulus	Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Stimulus Regulation Of Type I Interferon Production Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity G2/M Transition Of Mitotic Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Monoubiquitination Response To Organic Substance Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction Positive Regulation Of Type I Interferon Production Mitotic Cell Cycle Phase Transition Toll-like Receptor 4 Signaling Pathway Cell Cycle Phase Transition Response To Abiotic Stimulus Mammary Gland Epithelium Development Signaling Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Cell Communication Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Signal Transduction Negative Regulation Of Gene Expression Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Biosynthetic Process Innate Immune Response Regulation Of Cellular Process Activation Of Innate Immune Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Immune System Process Protein Destabilization G1/S Transition Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Mammary Gland Development Protein Polyubiquitination Circadian Rhythm Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Innate Immune Response
Tagcloud ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted	adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized gef guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 rapgef2 scf skp1 ubiquitylated ubiquitylation
Tagcloud (Difference) ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted	adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized gef guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 rapgef2 scf skp1 ubiquitylated ubiquitylation
Tagcloud (Intersection) ?