IFNAR1 and IFNW1

Number of citations of the paper that reports this interaction (PMID 1834641)
6

Data Source:
HPRD (in vivo)

		IFNAR1	IFNW1
Gene Name		interferon (alpha, beta and omega) receptor 1	interferon, omega 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Space
	Molecular Function	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding
	Biological Process	Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production T Cell Activation Type I Interferon Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Cell Cycle Arrest Response To Virus Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Response To Exogenous DsRNA Innate Immune Response Regulation Of MHC Class I Biosynthetic Process Defense Response To Virus
Pathways		Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 23128233)
Protein-Protein Interactions		21 interactors: CRKL FBXW11 GNB2L1 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC STAT2 STAT3 TYK2 ZAP70	2 interactors: APP IFNAR1
Entrez ID		3454	3467
HPRD ID		00126	00944
Ensembl ID		ENSG00000142166	ENSG00000177047
Uniprot IDs		B4DNT3 P17181	P05000
PDB IDs		3S98 3SE3 3SE4	3SE4
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Defense Response Innate Immune Response Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Organic Substance Response To Type I Interferon Regulation Of Cellular Ketone Metabolic Process Response To Cytokine Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell Adhesion Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of T Cell Activation Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Activation Immune System Development Cellular Response To Stimulus	Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cell Activation Type I Interferon Biosynthetic Process Innate Immune Response Type I Interferon Production Cellular Copper Ion Homeostasis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Copper Ion Homeostasis Suckling Behavior Regulation Of Interleukin-1 Beta Secretion Cytokine Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Interleukin-1 Beta Production Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cytokine Metabolic Process Cell Adhesion Positive Regulation Of Interleukin-1 Production Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Immune Response RNA Polyadenylation Neuron Recognition Defense Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interferon-gamma Production Axon Cargo Transport Mating Neuromuscular Junction Development JAK-STAT Cascade Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior
Tagcloud ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Difference) ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Intersection) ?