IFNAR1 and IFNA2

Number of citations of the paper that reports this interaction (PubMedID 1834641)
0

Data Source:
HPRD (in vivo)

		IFNAR1	IFNA2
Description		interferon alpha and beta receptor subunit 1	interferon alpha 2
Image
GO Annotations	Cellular Component	Lysosome Endosome Late Endosome Plasma Membrane Membrane Receptor Complex	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Cytokine Binding Type I Interferon Binding	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cellular Respiration	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Apoptotic Process Defense Response Inflammatory Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Response To Exogenous DsRNA Negative Regulation Of T Cell Differentiation Negative Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Peginterferon beta-1a Anifrolumab Human interferon beta Ropeginterferon alfa-2b	Sifalimumab
Diseases
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 23128233) Psoriasis ( 25903422)	Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		26 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK LRPAP1 MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70	3 interacting genes: IFNAR1 IFNAR2 TIMMDC1
Entrez ID		3454	3440
HPRD ID		00126	00950
Ensembl ID		ENSG00000142166	ENSG00000188379
Uniprot IDs		A0A8V8TQK8 A0A994J6F6 P17181	P01563
PDB IDs		3S98 3SE3 3SE4 4PO6 8Y31	1ITF 1RH2 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Type I Interferon-mediated Signaling Pathway Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Immune Response Cytokine Receptor Binding Regulation Of Hemopoiesis T Cell Activation Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Type I Interferon Receptor Binding Regulation Of Cytokine Production Cellular Response To Virus Positive Regulation Of Signal Transduction Protein Modification Process Natural Killer Cell Activation Involved In Immune Response Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Exogenous DsRNA Regulation Of Intracellular Signal Transduction Cell Activation Involved In Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Developmental Process Leukocyte Activation Response To DsRNA Positive Regulation Of Immune System Process B Cell Activation Regulation Of Multicellular Organismal Process Immune System Process Lymphocyte Activation Natural Killer Cell Activation Cell Activation Phosphate-containing Compound Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Gene Expression	Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Response To Interferon-alpha Cellular Response To Interferon-beta Response To Interferon-beta Cytokine Binding Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization To Nucleus Interferon Receptor Activity Receptor Complex Response To Virus Cellular Response To Interferon-alpha Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Localization Positive Regulation Of Cellular Respiration Response To Cytokine Response To Peptide Mitochondrial Respiratory Chain Complex I Assembly NADH Dehydrogenase Complex Assembly Regulation Of Cellular Respiration Regulation Of Protein Localization Response To Other Organism Mitochondrial Respiratory Chain Complex Assembly Response To External Biotic Stimulus
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