IFNAR1 and IFNA2

Number of citations of the paper that reports this interaction (PMID 1834641)
6

Data Source:
HPRD (in vivo)

		IFNAR1	IFNA2
Gene Name		interferon (alpha, beta and omega) receptor 1	interferon, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding	Cytokine Activity Type I Interferon Receptor Binding Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production T Cell Activation Type I Interferon Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Innate Immune Response Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Interleukin-5 Secretion Negative Regulation Of Interleukin-13 Secretion
Pathways		Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of IFNA signaling Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 23128233)
Protein-Protein Interactions		21 interactors: CRKL FBXW11 GNB2L1 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC STAT2 STAT3 TYK2 ZAP70	2 interactors: IFNAR1 IFNAR2
Entrez ID		3454	3440
HPRD ID		00126	00950
Ensembl ID		ENSG00000142166	ENSG00000188379
Uniprot IDs		B4DNT3 P17181	P01563 Q6DJX8
PDB IDs		3S98 3SE3 3SE4	1ITF 1RH2 2HIE 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Defense Response Innate Immune Response Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Organic Substance Response To Type I Interferon Regulation Of Cellular Ketone Metabolic Process Response To Cytokine Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell Adhesion Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of T Cell Activation Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Activation Immune System Development Cellular Response To Stimulus	Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Type I Interferon Biosynthetic Process Response To Cytokine Response To Other Organism Response To Biotic Stimulus Innate Immune Response Type I Interferon Production Response To Interferon-alpha Regulation Of Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Cytokine Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Cytokine Metabolic Process Positive Regulation Of Interleukin-1 Production Immune Response Regulation Of Immune System Process Defense Response Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interferon-gamma Production Response To External Stimulus Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Secretion Immune System Process Regulation Of Cytokine Secretion Response To Organic Substance Cytokine Production Defense Response To Virus Regulation Of Signal Transduction Positive Regulation Of Protein Secretion Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Stress T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion
Tagcloud ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted	2d antiviral attractive circular cleaved compromised dichroism fermenter hairy heteronuclear historically industry interferon leaving leukocytes makes nibsc pbl pharmaceutical protocols purification scheme science sumo tag tertiary ulp1 ultracentrifugation yields
Tagcloud (Difference) ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted	2d antiviral attractive circular cleaved compromised dichroism fermenter hairy heteronuclear historically industry interferon leaving leukocytes makes nibsc pbl pharmaceutical protocols purification scheme science sumo tag tertiary ulp1 ultracentrifugation yields
Tagcloud (Intersection) ?