IFNAR1 and IFNA1

Number of citations of the paper that reports this interaction (PMID 7932753)
18

Data Source:
HPRD (in vitro)

		IFNAR1	IFNA1
Gene Name		interferon (alpha, beta and omega) receptor 1	interferon, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding	Cytokine Activity Type I Interferon Receptor Binding
	Biological Process	Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production T Cell Activation Type I Interferon Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Blood Coagulation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Response To Exogenous DsRNA Innate Immune Response Regulation Of MHC Class I Biosynthetic Process Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of IFNA signaling Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 23128233)
Protein-Protein Interactions		21 interactors: CRKL FBXW11 GNB2L1 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC STAT2 STAT3 TYK2 ZAP70	4 interactors: CR2 IFNAR1 IL2 IRF9
Entrez ID		3454	3439
HPRD ID		00126	00974
Ensembl ID		ENSG00000142166	ENSG00000197919
Uniprot IDs		B4DNT3 P17181	L0N195 P01562
PDB IDs		3S98 3SE3 3SE4	3UX9
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Defense Response Innate Immune Response Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Cellular Response To Organic Substance Response To Type I Interferon Regulation Of Cellular Ketone Metabolic Process Response To Cytokine Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell Adhesion Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of T Cell Activation Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Activation Immune System Development Cellular Response To Stimulus	Type I Interferon Biosynthetic Process Type I Interferon Production Cytokine Biosynthetic Process Immune Response Cytokine Metabolic Process Lymphocyte Activation Positive Regulation Of Interferon-gamma Production Leukocyte Activation Immune System Process Regulation Of Interferon-gamma Production Cell Activation Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Innate Immune Response Regulation Of Immune Response Cytokine Production Defense Response To Virus Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Secretion Regulation Of T Cell Homeostatic Proliferation Lymphocyte Differentiation Regulation Of Immune System Process Defense Response Response To Virus Complement Receptor Mediated Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Positive Regulation Of Regulatory T Cell Differentiation Leukocyte Cell-cell Adhesion Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Secretion Homotypic Cell-cell Adhesion Leukocyte Differentiation Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Immunoglobulin Secretion Regulation Of Isotype Switching To IgG Isotypes Regulation Of Protein Secretion Positive Regulation Of Interleukin-17 Production Negative Regulation Of B Cell Apoptotic Process Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immunoglobulin Secretion Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of B Cell Apoptotic Process
Tagcloud ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted	adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifngr1 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifngr1 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted