PTPRC and GRB7

		PTPRC	GRB7
Description		protein tyrosine phosphatase receptor type C	growth factor receptor bound protein 7
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Bleb Membrane Raft Synapse Extracellular Exosome Cell Periphery Side Of Membrane Membrane Microdomain	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Anchoring Junction
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Heparin Binding Hydrolase Activity Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Ankyrin Binding Spectrin Binding Heparan Sulfate Proteoglycan Binding	RNA Binding Protein Binding Lipid Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Natural Killer Cell Differentiation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Mediated Immunity Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Response To Gamma Radiation Regulation Of Gene Expression Dephosphorylation B Cell Differentiation T Cell Differentiation Positive Regulation Of B Cell Proliferation Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Gamma-delta T Cell Differentiation Positive Regulation Of MAPK Cascade Cell Cycle Phase Transition Plasma Membrane Raft Distribution Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Alpha-beta T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Stem Cell Development Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Microglial Cell Activation Response To Aldosterone DN2 Thymocyte Differentiation Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways		Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation	GRB7 events in ERBB2 signaling Signaling by SCF-KIT Downstream signal transduction Tie2 Signaling RET signaling RND1 GTPase cycle
Drugs
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 34103634 32296059 31619474 30929738) Asthma (adult onset) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 28067908 26192919) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) LDL cholesterol levels ( 32203549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 20139978 29403010 28017375) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 33272962) Type 1 diabetes ( 34012112) Ulcerative colitis ( 24837172) Vitiligo ( 27723757) White blood cell count ( 32888494)	Asthma ( 28461288 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Crohn's disease ( 28067908) Height ( 31562340) Inflammatory bowel disease ( 28067908) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 20228799 28067908)
Interacting Genes		45 interacting genes: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MAPK1 MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 SRC TYK2 UHRF2 ZAP70	54 interacting genes: A1BG AGAP1 AR ATP5F1B CALM1 CAV1 CPNE6 CREBRF DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 ERBB4 FAM124B FCHO1 FGB FLAD1 GIGYF1 GIGYF2 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MET MSH2 PDGFRB PDHB PHAX PICK1 PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 STAC3 TCF12 TEK TGM5 TLE1 TMSB4X TRIM36 TRIM43 USP2 ZBTB16 ZNHIT1
Entrez ID		5788	2886
HPRD ID		01050	03311
Ensembl ID		ENSG00000081237	ENSG00000141738
Uniprot IDs		M9MML4 P08575	A0A0S2Z4F6 Q14451
PDB IDs		1YGR 1YGU 5FMV 5FN6 5FN7 8VSE	1MW4 1WGR 2L4K 2QMS 3PQZ 4WWQ 4X6S 5D0J 5EEL 5EEQ 5TYI 5U06 5U1Q 7MP3
Enriched GO Terms of Interacting Partners?		Leukocyte Activation Cell Surface Receptor Signaling Pathway Lymphocyte Activation Cell Activation Regulation Of Immune Response Positive Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation T Cell Costimulation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of Lymphocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune Response Immune System Process Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Signaling Pathway Immune Response Activation Of Immune Response T Cell Activation Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway T Cell Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Kinase Activity Protein Phosphorylation Regulation Of Leukocyte Proliferation Phosphorylation Immune Effector Process Signaling Receptor Binding Lymphocyte Differentiation Regulation Of Mononuclear Cell Proliferation Fc Receptor Signaling Pathway Mononuclear Cell Differentiation	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Receptor Complex Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Kinase Activity Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Signal Transduction Regulation Of Cell Adhesion Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process ERBB2 Signaling Pathway Transferase Activity Focal Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Positive Regulation Of Protein Modification Process Cellular Developmental Process Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Regulation Of Receptor Signaling Pathway Via JAK-STAT Nucleotide Binding ATP Binding Regulation Of Locomotion Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction Regulation Of Developmental Process
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