GRB7 and KIT

Number of citations of the paper that reports this interaction (PMID 10377264)
17

Data Source:
BioGRID (pull down, unspecified method)
HPRD (in vivo, in vitro)

		GRB7	KIT
Gene Name		growth factor receptor-bound protein 7	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection	Acrosomal Vesicle Extracellular Space Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Mast Cell Granule
	Molecular Function	RNA Binding SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	Protease Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Stem Cell Factor Receptor Activity Protein Binding ATP Binding Cytokine Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Leukocyte Migration	Activation Of MAPK Activity Ovarian Follicle Development Myeloid Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Dendritic Cell Cytokine Production Mast Cell Chemotaxis Glycosphingolipid Metabolic Process Inflammatory Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Spermatogenesis Spermatid Development Positive Regulation Of Cell Proliferation Germ Cell Migration Regulation Of Cell Shape Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Maintenance Signal Transduction By Phosphorylation Lamellipodium Assembly Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Melanocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Reorganization Mast Cell Cytokine Production Somatic Stem Cell Maintenance Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Megakaryocyte Development Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Programmed Cell Death Mast Cell Degranulation Positive Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of JAK-STAT Cascade Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Developmental Pigmentation Somatic Stem Cell Division Positive Regulation Of Long-term Neuronal Synaptic Plasticity Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Chemotaxis Mast Cell Differentiation Mast Cell Proliferation Cellular Response To Thyroid Hormone Stimulus Melanocyte Migration Melanocyte Adhesion
Pathways		Signaling by PDGF Signaling by SCF-KIT Signaling by ERBB2 Downstream signal transduction GRB7 events in ERBB2 signaling Tie2 Signaling Cell surface interactions at the vascular wall	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of KIT signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Adenosine-5\'-Diphosphate Nilotinib Pazopanib Regorafenib Ponatinib
Diseases
GWAS			Bipolar disorder ( 19416921) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		39 interactors: A1BG AGAP1 ATP5B CALM1 CAV1 CPNE6 DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 FGB FLAD1 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MSH2 PDGFRB PDHB PHAX PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 TEK TLE1 TMSB4X TRIM36 ZBTB16	56 interactors: ABL1 BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF2RA CSF2RB DOK1 EPOR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK IL7R INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ PIK3CG PIK3R1 PIK3R2 PLCE1 PLCG1 PRKCA PRKCB PTPN11 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SOCS1 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B TEC YES1
Entrez ID		2886	3815
HPRD ID		03311	01287
Ensembl ID		ENSG00000141738	ENSG00000157404
Uniprot IDs		Q14451	P10721
PDB IDs		1MW4 1WGR 2L4K 2QMS 3PQZ	1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2VIF 3G0E 3G0F 4HVS
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Immune System Process Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Wound Healing Immune Response-regulating Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Ketone Metabolic Process Regulation Of Catalytic Activity Regulation Of Immune System Process Regulation Of Signal Transduction Response To Wounding Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-amino Acid Modification Signal Transduction By Phosphorylation Positive Regulation Of Cellular Metabolic Process Response To Hormone Regulation Of Cellular Protein Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Immune Response Regulation Of Immune System Process Response To Peptide Hormone Positive Regulation Of Immune System Process Signal Transduction Cellular Response To Organonitrogen Compound Intracellular Signal Transduction Cellular Response To Organic Substance Response To Peptide Regulation Of Body Fluid Levels Response To Organic Substance Immune System Process Signaling Regulation Of Cell Activation Cell Communication Cellular Response To Hormone Stimulus Blood Coagulation Hemostasis Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Wound Healing Regulation Of Signaling Innate Immune Response Regulation Of Cell Adhesion Response To Organonitrogen Compound Regulation Of Lymphocyte Activation Response To Hormone Immune Response-regulating Signaling Pathway Cellular Response To Stimulus Leukocyte Migration Immune Response Response To Wounding Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Activation
Tagcloud ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	advantage blast blasts cd34 clonal clusters colonies continuously csf cytokines granulocyte immunomagnetic leukemic macrophage microspheres ng physiologic progenitor purified rg rgm ril rm rscf saturating scf subdivided supported undifferentiated
Tagcloud (Difference) ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	advantage blast blasts cd34 clonal clusters colonies continuously csf cytokines granulocyte immunomagnetic leukemic macrophage microspheres ng physiologic progenitor purified rg rgm ril rm rscf saturating scf subdivided supported undifferentiated
Tagcloud (Intersection) ?