Wiki-Pi
About
Search
People
Updates
Search
GRB7 and PDGFRB
Number of citations of the paper that reports this interaction (PubMedID
8940081
)
0
Data Source:
HPRD
(in vitro, in vivo)
GRB7
PDGFRB
Description
growth factor receptor bound protein 7
platelet derived growth factor receptor beta
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Cytoplasmic Stress Granule
Membrane
Cell Projection
Anchoring Junction
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Plasma Membrane
Focal Adhesion
Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Receptor Complex
Molecular Function
RNA Binding
Protein Binding
Lipid Binding
Protein Kinase Binding
Phosphatidylinositol Binding
Identical Protein Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
GTPase Activator Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Platelet-derived Growth Factor Binding
Phospholipase C Activator Activity
Biological Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Negative Regulation Of Translation
Positive Regulation Of Cell Migration
Stress Granule Assembly
Negative Regulation Of Insulin Receptor Signaling Pathway
Angiogenesis
Chemotaxis
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Smooth Muscle Adaptation
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Regulation Of Actin Cytoskeleton Organization
Cell Migration Involved In Vasculogenesis
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Calcium-mediated Signaling
Positive Regulation Of Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Myofibril Assembly
Cell Chemotaxis
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Pathways
GRB7 events in ERBB2 signaling
Signaling by SCF-KIT
Downstream signal transduction
Tie2 Signaling
RET signaling
RND1 GTPase cycle
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Tivozanib
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Diseases
Glioma
GWAS
Asthma (
28461288
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Asthma with severe exacerbations (
32841424
)
Crohn's disease (
28067908
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
26502338
)
Type 1 diabetes (age at diagnosis) (
33179336
)
Ulcerative colitis (
20228799
28067908
)
Blood protein levels (
30072576
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Interacting Genes
54 interacting genes:
A1BG
AGAP1
AR
ATP5F1B
CALM1
CAV1
CPNE6
CREBRF
DOCK7
DYNC1I1
EGFR
ERBB2
ERBB3
ERBB4
FAM124B
FCHO1
FGB
FLAD1
GIGYF1
GIGYF2
GNB2
GRB2
HADHB
INSR
KCTD6
KIT
KMT2B
LAX1
LY6G6F
MAP3K14
MET
MSH2
PDGFRB
PDHB
PHAX
PICK1
PKM
PTK2
RET
RND1
RPS2
SETDB1
SHC1
STAC3
TCF12
TEK
TGM5
TLE1
TMSB4X
TRIM36
TRIM43
USP2
ZBTB16
ZNHIT1
78 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
LCOR
NCK1
NCK2
NEDD4
NHERF1
NHERF2
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SNX1
SNX2
SNX27
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
Entrez ID
2886
5159
HPRD ID
03311
01423
Ensembl ID
ENSG00000141738
ENSG00000113721
Uniprot IDs
A0A0S2Z4F6
Q14451
P09619
Q59F04
PDB IDs
1MW4
1WGR
2L4K
2QMS
3PQZ
4WWQ
4X6S
5D0J
5EEL
5EEQ
5TYI
5U06
5U1Q
7MP3
1GQ5
1H9O
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
Enriched GO Terms of Interacting Partners
?
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
Receptor Complex
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
ERBB Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Protein Kinase Activity
Kinase Activity
Insulin-like Growth Factor Receptor Signaling Pathway
Basal Plasma Membrane
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Animal Organ Development
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Phosphate Metabolic Process
ERBB2 Signaling Pathway
Transferase Activity
Focal Adhesion
Positive Regulation Of Signal Transduction
Regulation Of Cell Migration
Regulation Of Programmed Cell Death
Positive Regulation Of ERK1 And ERK2 Cascade
Plasma Membrane
Positive Regulation Of Protein Modification Process
Cellular Developmental Process
Regulation Of Cell Motility
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Nucleotide Binding
ATP Binding
Regulation Of Locomotion
Positive Regulation Of Metabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Signal Transduction
Regulation Of Developmental Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion
ERBB Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Cytosol
Positive Regulation Of Cell Adhesion
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Insulin Receptor Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Migration
Growth Hormone Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Locomotion
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Migration
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of T Cell Activation
Regulation Of Programmed Cell Death
Regulation Of Cell Motility
Regulation Of Immune System Process
Positive Regulation Of Cell Motility
T Cell Activation
Cell Activation
Ephrin Receptor Binding
Receptor Tyrosine Kinase Binding
Positive Regulation Of Locomotion
Positive Regulation Of T Cell Activation
Cell Migration
Response To Growth Factor
Positive Regulation Of Multicellular Organismal Process
Regulation Of Biological Quality
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?