GRB7 and FGB

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GRB7	FGB
Gene Name		growth factor receptor-bound protein 7	fibrinogen beta chain
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Vesicle Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	RNA Binding SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	Receptor Binding Structural Molecule Activity Protein Binding Protein Binding, Bridging Cell Adhesion Molecule Binding Chaperone Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Leukocyte Migration	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Cellular Response To Leptin Stimulus Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Interleukin-1 Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Signaling by PDGF Signaling by SCF-KIT Signaling by ERBB2 Downstream signal transduction GRB7 events in ERBB2 signaling Tie2 Signaling Cell surface interactions at the vascular wall	p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet degranulation Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Fibrinogen ( 20031576 20031577 21757653)
Protein-Protein Interactions		39 interactors: A1BG AGAP1 ATP5B CALM1 CAV1 CPNE6 DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 FGB FLAD1 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MSH2 PDGFRB PDHB PHAX PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 TEK TLE1 TMSB4X TRIM36 ZBTB16	15 interactors: AIMP2 ANXA7 CALR CDKN1A CSNK2B FBLN1 FGA FGG GRB7 LPA NID1 PIK3R3 SERPINA5 SMN1 TK1
Entrez ID		2886	2244
HPRD ID		03311	00620
Ensembl ID		ENSG00000141738
Uniprot IDs		Q14451	P02675
PDB IDs		1MW4 1WGR 2L4K 2QMS 3PQZ	1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3BVH 3E1I 3GHG 3H32 3HUS
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Immune System Process Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Wound Healing Immune Response-regulating Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Ketone Metabolic Process Regulation Of Catalytic Activity Regulation Of Immune System Process Regulation Of Signal Transduction Response To Wounding Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-amino Acid Modification Signal Transduction By Phosphorylation Positive Regulation Of Cellular Metabolic Process Response To Hormone Regulation Of Cellular Protein Metabolic Process	Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Metal Ion Regulation Of Protein Metabolic Process Cellular Macromolecular Complex Assembly Hemostasis Regulation Of Cell-substrate Adhesion Response To Inorganic Substance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Body Fluid Levels Cellular Protein Complex Assembly Response To Calcium Ion Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Cellular Component Assembly Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Cell-matrix Adhesion Cellular Senescence Regulation Of Phosphorus Metabolic Process Regulation Of Cell Morphogenesis Positive Regulation Of Vasoconstriction Response To Hormone Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Catalytic Activity Protein Complex Assembly Cell-substrate Adhesion Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Adhesion Regulation Of Vasoconstriction Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Peptide Antigen Assembly With MHC Class I Protein Complex Fetal Process Involved In Parturition Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exocytosis
Tagcloud ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	assigned correlations decreasing delta deltafbg deltahoma diagnosed dipeptidyl dpp effectively efficacies fasting glycemic hba1c homa homeostasis hypoglycemic japanese monotherapy naive newly noted peptidase reductions safely t2dm teneligliptin ua uric
Tagcloud (Difference) ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f	assigned correlations decreasing delta deltafbg deltahoma diagnosed dipeptidyl dpp effectively efficacies fasting glycemic hba1c homa homeostasis hypoglycemic japanese monotherapy naive newly noted peptidase reductions safely t2dm teneligliptin ua uric
Tagcloud (Intersection) ?