GRB7 and HADHB

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GRB7	HADHB
Gene Name		growth factor receptor-bound protein 7	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Nucleoid Extracellular Vesicular Exosome
	Molecular Function	RNA Binding SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	Fatty-acyl-CoA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Acetyl-CoA C-acyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Long-chain-enoyl-CoA Hydratase Activity Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity Protein Complex Binding Poly(A) RNA Binding NAD Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Leukocyte Migration	Fatty Acid Beta-oxidation Phospholipid Metabolic Process Cardiolipin Acyl-chain Remodeling Cellular Lipid Metabolic Process Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways		Signaling by PDGF Signaling by SCF-KIT Signaling by ERBB2 Downstream signal transduction GRB7 events in ERBB2 signaling Tie2 Signaling Cell surface interactions at the vascular wall	Acyl chain remodeling of CL Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Mitochondrial Fatty Acid Beta-Oxidation Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Glycerophospholipid biosynthesis Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA mitochondrial fatty acid beta-oxidation of saturated fatty acids Beta oxidation of myristoyl-CoA to lauroyl-CoA Phospholipid metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		39 interactors: A1BG AGAP1 ATP5B CALM1 CAV1 CPNE6 DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 FGB FLAD1 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MSH2 PDGFRB PDHB PHAX PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 TEK TLE1 TMSB4X TRIM36 ZBTB16	12 interactors: ANXA7 APP CDKN1A CHCHD4 COX17 GRB7 RCC1 SMN1 SUOX TIMM8B TK1 TNNI3K
Entrez ID		2886	3032
HPRD ID		03311	00887
Ensembl ID		ENSG00000141738	ENSG00000138029
Uniprot IDs		Q14451	B4E2W0 F5GZQ3 P55084
PDB IDs		1MW4 1WGR 2L4K 2QMS 3PQZ
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Immune System Process Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Wound Healing Immune Response-regulating Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Ketone Metabolic Process Regulation Of Catalytic Activity Regulation Of Immune System Process Regulation Of Signal Transduction Response To Wounding Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-amino Acid Modification Signal Transduction By Phosphorylation Positive Regulation Of Cellular Metabolic Process Response To Hormone Regulation Of Cellular Protein Metabolic Process	Protein Targeting To Mitochondrion Protein Import Into Mitochondrial Intermembrane Space Fetal Process Involved In Parturition Protein Localization To Mitochondrion Regulation Of Mitotic Cell Cycle Skeletal Muscle Cell Proliferation Synaptic Growth At Neuromuscular Junction Hemostasis Collateral Sprouting In Absence Of Injury Cellular Component Assembly Regulation Of Cell Cycle Process Digestive Tract Development Collateral Sprouting Axon Midline Choice Point Recognition Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase Intestinal Epithelial Cell Maturation Cell Maturation Digestive System Development Regulation Of Body Fluid Levels Mitochondrial Transport Response To Glucocorticoid G1/S Transition Of Mitotic Cell Cycle Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Cortisol Thymidine Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Corticosteroid Ribonucleoprotein Complex Assembly Axon Choice Point Recognition Response To Toxic Substance Cellular Response To UV-B Chaperone-mediated Protein Transport Deoxyribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Ran GTPase Activity Neuron Remodeling Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Stress-induced Premature Senescence Protein Maturation By Protein Folding Regulation Of Cell Cycle Phase Transition
Tagcloud ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Difference) ?		adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Intersection) ?