HES4 and PCBD1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		HES4	PCBD1
Gene Name		hes family bHLH transcription factor 4	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Transcription Factor Binding Protein Dimerization Activity	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nervous System Development Cell Differentiation	Transcription, DNA-templated L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Protein Homodimerization Activity Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Homotetramerization Protein Heterooligomerization Oxidation-reduction Process
Pathways			Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: COPG2 LTN1 PCBD1 PCBD2 RGS3	49 interactors: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NUDT18 PAH PAPOLG PCBD2 POLR3A RBL2 RPS24 SAP30 SCMH1 SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WDYHV1 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF714
Entrez ID		57801	5092
HPRD ID		16273	00523
Ensembl ID		ENSG00000188290	ENSG00000166228
Uniprot IDs		D6REB3 E9PB28 Q9HCC6	P61457
PDB IDs
Enriched GO Terms of Interacting Partners?		Tetrahydrobiopterin Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Pteridine-containing Compound Metabolic Process Protein Homotetramerization Protein Tetramerization Protein Heterooligomerization Coenzyme Biosynthetic Process Protein Homooligomerization Cofactor Metabolic Process L-phenylalanine Catabolic Process L-phenylalanine Metabolic Process Protein Oligomerization Regulation Of Protein Homodimerization Activity	RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Metabolic Process Chromatin Remodeling Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Chromatin Organization Insulin Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Endocrine Pancreas Development Regulation Of Cellular Process Peptide Hormone Secretion Peptide Secretion Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Cellular Process Positive Regulation Of DNA-templated Transcription, Initiation Hormone Secretion
Tagcloud ?		brains contributions cpg dysregulation epigenome excessive gpr3 h3k4me3 hairy hd htt huntington hypermethylation jagged2 lastly mapping mark mash1 methylated modifying neurodegeneration pdia6 prefrontal shrna split striatal strikingly tmem106b trimethyl
Tagcloud (Difference) ?		brains contributions cpg dysregulation epigenome excessive gpr3 h3k4me3 hairy hd htt huntington hypermethylation jagged2 lastly mapping mark mash1 methylated modifying neurodegeneration pdia6 prefrontal shrna split striatal strikingly tmem106b trimethyl
Tagcloud (Intersection) ?