CGN and TP53BP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CGN	TP53BP2
Description		cingulin	tumor protein p53 binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Myosin Complex Cell Junction Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Cadherin Binding	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding
	Biological Process	Microtubule Cytoskeleton Organization	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)
Interacting Genes		10 interacting genes: ARHGEF2 CDC42 F11R LNX1 PPP1R13B RNF10 TJP1 TJP2 TP53BP2 YWHAG	119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575
Entrez ID		57530	7159
HPRD ID		10827	11803
Ensembl ID		ENSG00000143375	ENSG00000143514
Uniprot IDs		Q9P2M7	Q13625
PDB IDs			1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?		Establishment Of Endothelial Intestinal Barrier Protein Localization To Cell-cell Junction Maintenance Of Blood-brain Barrier Tight Junction Establishment Of Endothelial Barrier Bicellular Tight Junction Endothelial Cell Development Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Bicellular Tight Junction Regulation Of Blood-brain Barrier Permeability Protein Localization To Cell Junction Regulation Of Stress Fiber Assembly Positive Regulation Of Vascular Permeability Regulation Of Supramolecular Fiber Organization Epithelial Cell Development Anchoring Junction Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Cell Junction Organization Cell-cell Junction Organization Positive Regulation Of Cell Adhesion Intestinal Absorption Anatomical Structure Homeostasis Tissue Homeostasis Negative Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Intracellular Protein Localization Cell Junction Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Vascular Permeability Regulation Of Actin Filament Organization Adherens Junction Organization Negative Regulation Of Cellular Component Organization Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Protein-containing Complex Cadherin Binding Regulation Of Membrane Permeability Circulatory System Process Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion P53 Binding Regulation Of Actin Cytoskeleton Organization Digestive System Process Ubiquitin Protein Ligase Activity Actin Cytoskeleton Organization PDZ Domain Binding Regulation Of Actin Filament-based Process Apical Part Of Cell GBD Domain Binding	Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression
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