CGN and TJP1

Number of citations of the paper that reports this interaction (PMID 10613913)
38

Data Source:
HPRD (in vitro, in vivo)

		CGN	TJP1
Gene Name		cingulin	tight junction protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Tight Junction Myosin Complex Cell Junction	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Gap Junction Tight Junction Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Apical Junction Complex Apical Part Of Cell Intercellular Canaliculus
	Molecular Function	Motor Activity Actin Binding Protein Binding Microtubule Binding	Protein Binding Calmodulin Binding Protein C-terminus Binding Protein Domain Specific Binding
	Biological Process	Microtubule Cytoskeleton Organization Epithelial Cell Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Biological_process Metabolic Process Tight Junction Assembly	Blastocyst Formation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Junction Assembly Sensory Perception Of Sound Response To Lipopolysaccharide Hippo Signaling Response To Drug Negative Regulation Of Vascular Permeability Response To Ethanol Membrane Organization Response To Magnetism Cellular Response To Glucose Stimulus Establishment Of Endothelial Intestinal Barrier Cell-cell Signaling Involved In Cell-cell Junction Organization
Pathways		Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Apoptotic cleavage of cell adhesion proteins c-src mediated regulation of Cx43 function and closure of gap junctions Apoptotic cleavage of cellular proteins Signaling by Hippo Gap junction trafficking and regulation Programmed Cell Death Apoptotic execution phase Regulation of gap junction activity
Drugs
Diseases
GWAS			Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Protein-Protein Interactions		6 interactors: ARHGEF2 F11R LNX1 TJP1 TJP2 YWHAG	38 interactors: ACTA1 ACTN4 ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL MLLT4 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		57530	7082
HPRD ID		10827	03002
Ensembl ID		ENSG00000143375	ENSG00000104067
Uniprot IDs		Q9P2M7	G3V1L9 Q07157 Q6MZU1
PDB IDs			2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ
Enriched GO Terms of Interacting Partners?		Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Endothelial Cell Differentiation Endothelium Development Epithelial Cell Development Intestinal Absorption Hippo Signaling Regulation Of Membrane Permeability Apoptotic Process Programmed Cell Death Cell Death Death Response To Organic Substance Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Epithelial Cell Differentiation Cell-cell Signaling Involved In Cell-cell Junction Organization Cell Differentiation Digestion Cell-cell Junction Assembly Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Muramyl Dipeptide Membrane Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To Magnetism Cell Junction Assembly Regulation Of Organelle Organization Cell-cell Junction Organization Epithelium Development Response To Abiotic Stimulus Anatomical Structure Development Regulation Of Rho GTPase Activity Regulation Of Response To Osmotic Stress Cellular Hyperosmotic Response Blood Circulation Signal Transduction Cellular Response To Peptide Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Developmental Process Cellular Protein Localization Negative Regulation Of Vascular Permeability Negative Regulation Of Rho GTPase Activity Signaling Negative Regulation Of Necroptotic Process Cell Communication Establishment Of Protein Localization Positive Regulation Of Rap GTPase Activity	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Junction Assembly Cell-cell Junction Assembly Gap Junction Assembly Cell Development Establishment Of Endothelial Intestinal Barrier Anatomical Structure Development Cellular Component Assembly Developmental Process Epithelial Cell Development Apical Junction Assembly Establishment Of Endothelial Barrier Endothelium Development Neuron Projection Development Regulation Of Body Fluid Levels Response To Abiotic Stimulus Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Tight Junction Assembly Transmembrane Transport Endothelial Cell Development Response To Organic Substance System Development Movement Of Cell Or Subcellular Component Neuron Development Cell Differentiation Atrial Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication Multicellular Organismal Development Locomotion Cell Communication Single Organismal Cell-cell Adhesion Epithelial Cell Differentiation Cell Morphogenesis Axon Development Endothelial Cell Differentiation Neuron Differentiation Cell-cell Signaling Involved In Cardiac Conduction Cell Projection Organization Positive Regulation Of Rap GTPase Activity Neurological System Process Establishment Of Skin Barrier Adherens Junction Organization Skin Development Neuron Projection Morphogenesis Cell-cell Signaling
Tagcloud ?		ac attenuate believed blots caspase cerebellar cho cytochrome cytosol cytosolic devd ensuing extracts fmk granule hydroxydopamine involves lacking laddering mitochondria neurotoxicity ohda pna points precedes protease reveal ultimately zvad	abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Difference) ?		ac attenuate believed caspase cerebellar cho cytochrome cytosol cytosolic devd ensuing extracts fmk granule hydroxydopamine involves lacking laddering mitochondria neurotoxicity ohda pna points precedes protease reveal ultimately zvad	abp androgen ar clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Intersection) ?		blots