CGN and TJP2

Number of citations of the paper that reports this interaction (PMID 10613913)
38

Data Source:
HPRD (in vitro, in vivo)

		CGN	TJP2
Gene Name		cingulin	tight junction protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Tight Junction Myosin Complex Cell Junction	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Tight Junction Cell Junction
	Molecular Function	Motor Activity Actin Binding Protein Binding Microtubule Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging
	Biological Process	Microtubule Cytoskeleton Organization Epithelial Cell Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Biological_process Metabolic Process Tight Junction Assembly	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Organic Substance Hippo Signaling Nucleotide Phosphorylation Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability
Pathways		Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Signaling by Hippo Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS			Refractive error ( 23396134) Renal sinus fat ( 22044751)
Protein-Protein Interactions		6 interactors: ARHGEF2 F11R LNX1 TJP1 TJP2 YWHAG	15 interactors: CDK6 CGN CLDN1 CLDN2 CTNNA1 EPB41 HGS OCLN SAFB SCRIB SH3KBP1 TJP1 YWHAB YWHAG YWHAZ
Entrez ID		57530	9414
HPRD ID		10827	06369
Ensembl ID		ENSG00000143375	ENSG00000119139
Uniprot IDs		Q9P2M7	B7Z2R3 B7Z954 Q9UDY2
PDB IDs			2OSG 3E17
Enriched GO Terms of Interacting Partners?		Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Endothelial Cell Differentiation Endothelium Development Epithelial Cell Development Intestinal Absorption Hippo Signaling Regulation Of Membrane Permeability Apoptotic Process Programmed Cell Death Cell Death Death Response To Organic Substance Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Epithelial Cell Differentiation Cell-cell Signaling Involved In Cell-cell Junction Organization Cell Differentiation Digestion Cell-cell Junction Assembly Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Muramyl Dipeptide Membrane Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To Magnetism Cell Junction Assembly Regulation Of Organelle Organization Cell-cell Junction Organization Epithelium Development Response To Abiotic Stimulus Anatomical Structure Development Regulation Of Rho GTPase Activity Regulation Of Response To Osmotic Stress Cellular Hyperosmotic Response Blood Circulation Signal Transduction Cellular Response To Peptide Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Developmental Process Cellular Protein Localization Negative Regulation Of Vascular Permeability Negative Regulation Of Rho GTPase Activity Signaling Negative Regulation Of Necroptotic Process Cell Communication Establishment Of Protein Localization Positive Regulation Of Rap GTPase Activity	Cell-cell Junction Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cell-cell Junction Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Death Cell Junction Assembly Positive Regulation Of Apoptotic Signaling Pathway Apical Junction Assembly Positive Regulation Of Mitochondrion Organization Epithelial Cell Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Mitochondrion Organization Signaling Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell Communication Protein Targeting Membrane Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Hippo Signaling Enzyme Linked Receptor Protein Signaling Pathway Intrinsic Apoptotic Signaling Pathway Signal Transduction Epithelial Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tight Junction Assembly Positive Regulation Of Intracellular Transport Negative Regulation Of ERBB Signaling Pathway Cell Development Cell Adhesion Cellular Component Assembly Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Involved In Cell-cell Junction Organization Cell Dedifferentiation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Signal Transduction Positive Regulation Of Transport Cellular Protein Localization Execution Phase Of Apoptosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Apoptotic Signaling Pathway Negative Regulation Of Integrin-mediated Signaling Pathway
Tagcloud ?		ac attenuate believed blots caspase cerebellar cho cytochrome cytosol cytosolic devd ensuing extracts fmk granule hydroxydopamine involves lacking laddering mitochondria neurotoxicity ohda pna points precedes protease reveal ultimately zvad
Tagcloud (Difference) ?		ac attenuate believed blots caspase cerebellar cho cytochrome cytosol cytosolic devd ensuing extracts fmk granule hydroxydopamine involves lacking laddering mitochondria neurotoxicity ohda pna points precedes protease reveal ultimately zvad
Tagcloud (Intersection) ?