TNKS2 and SH3BP2

Number of citations of the paper that reports this interaction (PMID 22153076)
20

Data Source:
BioGRID (enzymatic study)

		TNKS2	SH3BP2
Gene Name		tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	SH3-domain binding protein 2
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Enzyme Binding Metal Ion Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding
	Biological Process	Protein Polyubiquitination Protein ADP-ribosylation Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Multicellular Organism Growth Regulation Of Multicellular Organism Growth Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway	Signal Transduction Positive Regulation Of Signal Transduction
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: GRB14 LNPEP MAPK1 SH3BP2 TERF1 TNKS TNKS1BP1 ZNF512B	21 interactors: ABL1 DBNL ERBB2 FGFR1 FLT3 FYN GRB2 LAT LCK PDLIM7 PLCG1 PLCG2 SH3KBP1 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70
Entrez ID		80351	6452
HPRD ID		06182	03657
Ensembl ID		ENSG00000107854	ENSG00000087266
Uniprot IDs		Q9H2K2	D6R919 P78314
PDB IDs		2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M	2CR4 3TWR
Enriched GO Terms of Interacting Partners?		Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Peptidyl-threonine Phosphorylation Telomere Maintenance Positive Regulation Of Signal Transduction MAPK Import Into Nucleus Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Peptidyl-serine Phosphorylation Regulation Of DNA Replication Telomeric Loop Formation Age-dependent Telomere Shortening Protein Poly-ADP-ribosylation Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Shortening Regulation Of Golgi Inheritance Protein Auto-ADP-ribosylation Protein Polyubiquitination Caveolin-mediated Endocytosis Cytosine Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Regulation Of Golgi Organization Positive Regulation Of Telomere Maintenance Regulation Of Organelle Organization Cellular Macromolecule Biosynthetic Process Replicative Cell Aging Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Macromolecule Biosynthetic Process Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Negative Regulation Of Telomere Maintenance DNA Replication Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Microtubule Polymerization Mitotic Nuclear Division Regulation Of Telomerase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation ERK1 And ERK2 Cascade	Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Innate Immune Response Wound Healing Hemostasis Platelet Activation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cell Activation Antigen Receptor-mediated Signaling Pathway Response To Wounding Positive Regulation Of Signal Transduction Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Immune Response Endocytosis Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Immune Response Defense Response Immune System Process Regulation Of Lymphocyte Activation Phagocytosis Cell Migration Vesicle-mediated Transport Cell Motility Positive Regulation Of Immune System Process Regulation Of Cell Activation Locomotion Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Regulation Of Intracellular Signal Transduction Leukocyte Migration Regulation Of Cell-cell Adhesion Cellular Response To Growth Factor Stimulus Response To Growth Factor Lymphocyte Activation
Tagcloud ?		abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp parp1 parp2 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 valuable	bilateral boy calcineurin candidates cherubism copyright disfigurement facial giant granuloma immunohistological intra jaw jaws multinucleated nfatc1 operative opg osseous osteoclastogenesis osteoclasts osteogenesis protected radiological rankl reserved rights stabilization tacrolimus
Tagcloud (Difference) ?		abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp parp1 parp2 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 valuable	bilateral boy calcineurin candidates cherubism copyright disfigurement facial giant granuloma immunohistological intra jaw jaws multinucleated nfatc1 operative opg osseous osteoclastogenesis osteoclasts osteogenesis protected radiological rankl reserved rights stabilization tacrolimus
Tagcloud (Intersection) ?