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TNKS2
Gene Name
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Pericentriolar Material
Nuclear Chromosome, Telomeric Region
Nucleus
Nuclear Envelope
Cytoplasm
Cytosol
Perinuclear Region Of Cytoplasm
Molecular Function
NAD+ ADP-ribosyltransferase Activity
Protein Binding
Enzyme Binding
Metal Ion Binding
Biological Process
Protein Polyubiquitination
Protein ADP-ribosylation
Wnt Signaling Pathway
Positive Regulation Of Telomere Maintenance Via Telomerase
Multicellular Organism Growth
Regulation Of Multicellular Organism Growth
Protein Localization To Chromosome, Telomeric Region
Protein Auto-ADP-ribosylation
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of AXIN
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions
8 interactors:
GRB14
LNPEP
MAPK1
SH3BP2
TERF1
TNKS
TNKS1BP1
ZNF512B
Entrez ID
80351
HPRD ID
06182
Ensembl ID
ENSG00000107854
Uniprot IDs
Q9H2K2
PDB IDs
2Y0I
3KR7
3KR8
3MHJ
3MHK
3P0N
3P0P
3P0Q
3TWQ
3TWR
3TWS
3TWT
3TWU
3TWV
3TWW
3TWX
3U9H
3U9Y
3UA9
3W51
4AVU
4AVW
4BFP
4HKI
4HKK
4HKN
4HL5
4HLF
4HLG
4HLH
4HLK
4HLM
4HMH
4HYF
4IUE
4J1Z
4J21
4J22
4J3L
4J3M
Enriched GO Terms of Interacting Partners
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Regulation Of Telomere Maintenance Via Telomerase
Telomere Maintenance Via Telomerase
Regulation Of Telomere Maintenance
RNA-dependent DNA Replication
Telomere Maintenance Via Telomere Lengthening
Peptidyl-threonine Phosphorylation
Telomere Maintenance
Positive Regulation Of Signal Transduction
MAPK Import Into Nucleus
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Peptidyl-serine Phosphorylation
Regulation Of DNA Replication
Telomeric Loop Formation
Age-dependent Telomere Shortening
Protein Poly-ADP-ribosylation
Positive Regulation Of Telomere Maintenance Via Telomerase
Telomere Maintenance Via Telomere Shortening
Regulation Of Golgi Inheritance
Protein Auto-ADP-ribosylation
Protein Polyubiquitination
Caveolin-mediated Endocytosis
Cytosine Metabolic Process
Protein Localization To Chromosome, Telomeric Region
Negative Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Chromosome Organization
Regulation Of Golgi Organization
Positive Regulation Of Telomere Maintenance
Regulation Of Organelle Organization
Cellular Macromolecule Biosynthetic Process
Replicative Cell Aging
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Macromolecule Biosynthetic Process
Regulation Of Nuclear Cell Cycle DNA Replication
Negative Regulation Of Telomerase Activity
Negative Regulation Of Telomere Maintenance
DNA Replication
Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Microtubule Polymerization
Mitotic Nuclear Division
Regulation Of Telomerase Activity
Positive Regulation Of Peptidyl-threonine Phosphorylation
ERK1 And ERK2 Cascade
Tagcloud
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abt
actively
adp
azd
bsi
continues
crystal
detailed
explored
guide
heightened
indications
inhibitors
insight
manifesting
modes
parp
parp1
parp2
parp5a
parp5b
poly
rational
relevance
ribose
stranded
tankyrase
tnks1
valuable