Description |
tankyrase 2 |
growth factor receptor bound protein 14 |
Image |
|
|
Cellular Component |
|
|
Molecular Function |
|
|
Biological Process |
|
|
Pathways |
|
|
Drugs |
|
|
Diseases |
|
|
GWAS |
- Appendicular lean mass ( 33097823)
- Liver enzyme levels (alkaline phosphatase) ( 33972514)
- Liver volume ( 34128465)
- Serum alkaline phosphatase levels ( 33547301)
|
- A body shape index ( 34021172)
- Adventurousness ( 30643258)
- Blood pressure ( 21572416 24954895)
- Body fat percentage ( 31453325 26833246)
- Body fat percentage variance ( 31453325)
- Body mass index ( 26426971 29381148)
- Body mass index (age>50) ( 26426971)
- Body mass index x sex x age interaction (4df test) ( 26426971)
- Coronary artery disease ( 33020668 32469254)
- Diastolic blood pressure ( 27618452 28739976)
- Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
- Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
- Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
- Fasting blood insulin ( 25631608)
- Fasting blood insulin (BMI interaction) ( 22581228)
- Glomerular filtration rate in chronic kidney disease ( 26420894)
- Glycine levels ( 30837465)
- HDL cholesterol levels ( 30698716)
- HDL cholesterol levels in current drinkers ( 30698716)
- HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- High density lipoprotein cholesterol levels ( 33339817)
- Hip circumference ( 25673412)
- Hip circumference adjusted for BMI ( 25673412)
- Hip index ( 34021172)
- Hypertension ( 30487518)
- Immunoglobulin A vasculitis ( 28698626)
- LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- Mean arterial pressure ( 30487518 29403010)
- Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
- Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
- Myocardial infarction ( 33532862)
- Number of sexual partners ( 30643258)
- Perceived sweetness of sucrose ( 31005972)
- Pulse pressure ( 27841878 28739976 30487518)
- Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
- Response to statin therapy ( 20339536)
- Sexual dimorphism in anthropometric traits ( 23754948)
- Systolic blood pressure ( 28739976 26390057 27618447 29403010 27618452 27841878 28135244)
- Systolic blood pressure (cigarette smoking interaction) ( 29455858)
- Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
- Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
- Triglyceride levels ( 32203549 30698716)
- Triglyceride levels in current drinkers ( 30698716)
- Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- Type 2 diabetes ( 30718926 21874001 22885922 28869590 24509480 32499647 30297969 29632382)
- Type 2 diabetes (adjusted for BMI) ( 29632382)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for BMI in active individuals ( 28448500)
- Waist circumference adjusted for BMI in non-smokers ( 28443625)
- Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)
- Waist-hip index ( 34021172)
- Waist-hip ratio ( 20935629 25673412)
- Waist-to-hip ratio adjusted for BMI ( 26426971 34021172)
- Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
- Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
- Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500)
- Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
- Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
|
Interacting Genes |
17 interacting genes:
AMOTL2
ANKRD28
ARAP3
DSCR9
GRB14
LNPEP
MAPK1
MAVS
MDC1
PTEN
SASH1
SH3BP2
TERF1
TNKS
TNKS1BP1
USP25
ZNF512B
|
25 interacting genes:
CDC5L
CHFR
DAPK3
EGFR
ERBB2
FGFR1
FRS3
GIGYF1
GIGYF2
GOLGA2
HCK
IGF1R
INSR
IRS1
MAP3K14
MET
PDGFRA
PDGFRB
PRKCZ
SQSTM1
STK26
TEK
TNKS2
TRIM27
TRIM55
|
Entrez ID |
80351 |
2888 |
HPRD ID |
06182 |
03313 |
Ensembl ID |
ENSG00000107854
|
ENSG00000115290
|
Uniprot IDs |
Q9H2K2
|
Q14449
|
PDB IDs |
2Y0I
3KR7
3KR8
3MHJ
3MHK
3P0N
3P0P
3P0Q
3TWQ
3TWR
3TWS
3TWT
3TWU
3TWV
3TWW
3TWX
3U9H
3U9Y
3UA9
3W51
4AVU
4AVW
4BFP
4BJ9
4BJB
4BJC
4BS4
4BU3
4BU5
4BU6
4BU7
4BU8
4BU9
4BUA
4BUD
4BUE
4BUF
4BUI
4BUS
4BUT
4BUU
4BUV
4BUW
4BUX
4BUY
4HKI
4HKK
4HKN
4HL5
4HLF
4HLG
4HLH
4HLK
4HLM
4HMH
4HYF
4IUE
4J1Z
4J21
4J22
4J3L
4J3M
4KZL
4KZQ
4KZU
4L09
4L0B
4L0I
4L0S
4L0T
4L0V
4L10
4L2F
4L2G
4L2K
4L31
4L32
4L33
4L34
4M7B
4PML
4PNL
4PNM
4PNN
4PNQ
4PNR
4PNS
4PNT
4TJU
4TJW
4TJY
4TK0
4TK5
4TKF
4TKG
4TKI
4UFU
4UFY
4UHG
4UI3
4UI4
4UI5
4UI6
4UI7
4UI8
4UVL
4UVN
4UVO
4UVP
4UVS
4UVT
4UVU
4UVV
4UVW
4UVX
4UVY
4UVZ
4UX4
4W5I
4Z68
5ADQ
5ADR
5ADS
5ADT
5AEH
5AKU
5AKW
5AL1
5AL2
5AL3
5AL4
5AL5
5BXO
5BXU
5C5P
5C5Q
5C5R
5DCZ
5FPF
5FPG
5JRT
5NOB
5NSP
5NUT
5OWS
5OWT
6TG4
6TKM
6TKN
6TKP
6TKQ
6TKR
6TKS
7A1S
7O6X
7POX
7R3Z
8ALY
|
2AUG
2AUH
4K81
|
Enriched GO Terms of Interacting Partners? |
- Protein Polyubiquitination
- Ankyrin Repeat Binding
- Positive Regulation Of Telomere Maintenance
- Peptidyl-threonine Phosphorylation
- Positive Regulation Of DNA Metabolic Process
- Positive Regulation Of Chromosome Organization
- Regulation Of Telomere Maintenance
- Negative Regulation Of Cell Cycle Process
- Telomere Maintenance Via Telomerase
- Protein Ubiquitination
- RNA-templated DNA Biosynthetic Process
- Negative Regulation Of Cell Cycle
- Telomere Maintenance Via Telomere Lengthening
- Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
- Protein Modification By Small Protein Conjugation
- Molecular Adaptor Activity
- Protein Modification Process
- Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
- Response To DsRNA
- Phosphotyrosine Residue Binding
- Response To Exogenous DsRNA
- Negative Regulation Of Synaptic Vesicle Clustering
- Regulation Of Telomere Maintenance Via Telomerase
- Negative Regulation Of Establishment Of Protein Localization To Telomere
- Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
- Negative Regulation Of Telomere Maintenance
- Negative Regulation Of Establishment Of RNA Localization To Telomere
- Positive Regulation Of Shelterin Complex Assembly
- Positive Regulation Of IP-10 Production
- Post-translational Protein Modification
- Regulation Of DNA Metabolic Process
- Regulation Of Telomere Maintenance Via Telomere Lengthening
- Regulation Of Chromosome Organization
- Cytosine Metabolic Process
- Regulation Of Focal Adhesion Assembly
- Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
- Regulation Of Epithelial Cell Migration
- Negative Regulation Of Keratinocyte Migration
- Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
- Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity
- Negative Regulation Of Telomeric D-loop Disassembly
- Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
- Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric
- Regulation Of Peroxisome Organization
- Signal Transduction
- Insulin Receptor Signaling Pathway
- Negative Regulation Of Metabolic Process
- Regulation Of Metabolic Process
- Interleukin-34-mediated Signaling Pathway
- Regulation Of Cell-substrate Junction Organization
|
|
Tagcloud ? |
|
|
Tagcloud (Difference) ? |
|
|
Tagcloud (Intersection) ? |
|