PAPPA2 and IGFBP5

Number of citations of the paper that reports this interaction (PMID 11264294)
22

Data Source:
HPRD (in vitro)

		PAPPA2	IGFBP5
Gene Name		pappalysin 2	insulin-like growth factor binding protein 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Intracellular Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Insulin-like Growth Factor Binding Protein Complex
	Molecular Function	Metallopeptidase Activity Zinc Ion Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Regulation Of Cell Growth Proteolysis Cell Differentiation Cellular Protein Metabolic Process Bone Morphogenesis	Regulation Of Cell Growth Osteoblast Differentiation Glucose Metabolic Process Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Skeletal Muscle Tissue Growth Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Cellular Response To CAMP Cellular Response To Organic Cyclic Compound
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Height ( 20881960)	Thyroid hormone levels ( 23408906) Visceral fat ( 22589738)
Protein-Protein Interactions		5 interactors: ATF7IP IGFBP3 IGFBP5 SMAD4 ZNF512B	17 interactors: ADAM12 BAG6 F2 FHL2 FN1 IGF1 IGF2 IGFALS KPNB1 PAPPA2 PNO1 RASSF1 SERPINE1 SPP1 TF THBS1 VTN
Entrez ID		60676	3488
HPRD ID		10156	00901
Ensembl ID		ENSG00000116183	ENSG00000115461
Uniprot IDs		Q9BXP8	P24593
PDB IDs			1BOE 1H59
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Growth Regulation Of Smooth Muscle Cell Proliferation Regulation Of Glucose Metabolic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Cell Proliferation Cell Proliferation Negative Regulation Of Cellular Metabolic Process Osteoblast Differentiation Nephrogenic Mesenchyme Morphogenesis Regulation Of Carbohydrate Metabolic Process Negative Regulation Of Protein Metabolic Process Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Skeletal Muscle Tissue Growth Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Skin Development Negative Regulation Of Cellular Component Movement Negative Regulation Of Locomotion Endocardial Cell Differentiation Mammary Gland Involution Developmental Growth Ossification Positive Regulation Of Signal Transduction Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Regulation Of Cell Proliferation Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Brainstem Development SMAD Protein Complex Assembly Regulation Of Cell Differentiation Regulation Of SMAD Protein Import Into Nucleus	Platelet Degranulation Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Exocytosis Wound Healing Regulation Of Fibrinolysis Cell Activation Response To Wounding Regulation Of Blood Coagulation Secretion By Cell Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Response To Stress Positive Regulation Of Blood Coagulation Response To Stimulus Regulation Of Wound Healing Regulation Of Cell Adhesion Secretion Positive Regulation Of Coagulation Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Protein Processing Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Processing Negative Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Coagulation Negative Regulation Of Plasminogen Activation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Wound Healing Cell Differentiation Striated Muscle Cell Differentiation Developmental Process Exocrine Pancreas Development Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase B Signaling Vesicle-mediated Transport Ossification
Tagcloud ?			4h antisense autocrine benzopyran c2 igfr igfs indirectly ly294002 messenger modulated morpholinyl myoblast myoblasts p70 p70s6k persisted phenyl phosphatidylinositol pi3 prevents proliferating quiescent rapamycin s6 stably wortmaninn
Tagcloud (Difference) ?			4h antisense autocrine benzopyran c2 igfr igfs indirectly ly294002 messenger modulated morpholinyl myoblast myoblasts p70 p70s6k persisted phenyl phosphatidylinositol pi3 prevents proliferating quiescent rapamycin s6 stably wortmaninn
Tagcloud (Intersection) ?