PAPPA2 and IGFBP3

Number of citations of the paper that reports this interaction (PubMedID 11264294)
0

Data Source:
HPRD (in vitro)

		PAPPA2	IGFBP3
Description		pappalysin 2	insulin like growth factor binding protein 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Apical Plasma Membrane Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Proteolysis Cell Surface Receptor Signaling Pathway Response To Salt Stress Bone Morphogenesis	MAPK Cascade Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Growth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation
Drugs			Alitretinoin Mecasermin
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) Birth weight ( 31043758) Body mass index ( 26426971) Fractional exhaled nitric oxide (childhood) ( 24315451) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Height ( 25429064 20881960 31562340) Hip circumference adjusted for BMI ( 34021172) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Offspring birth weight ( 31043758) Pediatric central nervous system tumors (late onset)(pleiotropy) ( 33226468) Pediatric central nervous system tumors (pleiotropy) ( 33226468) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulse pressure ( 30578418 27841878) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 23696881 30072576) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418 28498854 27841878) FEV1 ( 30804560) Height ( 33713608 25282103 31562340) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 30487518 29403010 28739976 28498854 28135244 27841878 27618448) QRS duration ( 21076409 27577874) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618448 27618447) Tonsillectomy ( 28928442 27182965) Venous thromboembolism ( 26888256) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		5 interacting genes: ATF7IP IGFBP3 IGFBP5 SMAD4 ZNF512B	38 interacting genes: ADAM12 AURKA BMPR1A BUB1 CAV1 CCND1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FBXW7 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 KRAS LTBP1 MLH3 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RAD54B RXRA STK11 TF
Entrez ID		60676	3486
HPRD ID		10156	00899
Ensembl ID		ENSG00000116183	ENSG00000146674
Uniprot IDs		Q9BXP8	B3KPF0 P17936
PDB IDs		8SL1	7WRQ
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Insulin-like Growth Factor II Binding Osteoblast Differentiation Insulin-like Growth Factor Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor I Binding Type B Pancreatic Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Fibronectin Binding Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Muscle Hypertrophy Growth Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Regulation Of MiRNA Transcription Negative Regulation Of Skeletal Muscle Hypertrophy Regulation Of MiRNA Metabolic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Negative Regulation Of Protein Metabolic Process Regulation Of Growth Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Cell Population Proliferation Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Epithelial Cell Proliferation Protein Tyrosine Phosphatase Activator Activity Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Macromolecule Biosynthetic Process Carbohydrate Homeostasis Mammary Gland Involution Glucose Homeostasis Negative Regulation Of Biosynthetic Process Sulfate Binding Endocardial Cell Differentiation Regulation Of Primary Metabolic Process MAPK Cascade Negative Regulation Of Growth Regulation Of Muscle System Process Transcription Regulator Complex SMAD Protein Complex	Extracellular Region Peptidase Activity Endopeptidase Activity Serine-type Endopeptidase Activity Extracellular Matrix Extracellular Space Cell Surface Receptor Signaling Pathway Response To UV-A Proteolysis Positive Regulation Of Signal Transduction Extracellular Matrix Disassembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Stress Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Collagen Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To UV-A Protein Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Apoptotic Process Response To UV Regulation Of Cell Population Proliferation Extracellular Matrix Organization Extracellular Structure Organization Biological Process Involved In Interaction With Symbiont Regulation Of Epithelial Cell Proliferation Positive Regulation Of Multicellular Organismal Process Cellular Response To UV Regulation Of Signal Transduction Metalloendopeptidase Activity Collagen Catabolic Process Regulation Of Programmed Cell Death Chemical Homeostasis Gland Development Homeostatic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Cellular Component Organization Cellular Response To Light Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Developmental Process Response To Radiation Hydrolase Activity Glucose Homeostasis
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