PAPPA2 and IGFBP3

Number of citations of the paper that reports this interaction (PMID 11264294)
22

Data Source:
HPRD (in vitro)

		PAPPA2	IGFBP3
Gene Name		pappalysin 2	insulin-like growth factor binding protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Intracellular Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Insulin-like Growth Factor Binding Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Metallopeptidase Activity Zinc Ion Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Proteolysis Cell Differentiation Cellular Protein Metabolic Process Bone Morphogenesis	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs			Mecasermin
Diseases
GWAS		Height ( 20881960)	Insulin-like growth factors ( 21216879) Major depressive disorder ( 23377640) Ventricular conduction ( 21076409)
Protein-Protein Interactions		5 interactors: ATF7IP IGFBP3 IGFBP5 SMAD4 ZNF512B	28 interactors: ADAM12 CAV1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 LTBP1 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 RXRA TF
Entrez ID		60676	3486
HPRD ID		10156	00899
Ensembl ID		ENSG00000116183	ENSG00000146674
Uniprot IDs		Q9BXP8	B3KPF0 B3KWK7 P17936
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Growth Regulation Of Smooth Muscle Cell Proliferation Regulation Of Glucose Metabolic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Cell Proliferation Cell Proliferation Negative Regulation Of Cellular Metabolic Process Osteoblast Differentiation Nephrogenic Mesenchyme Morphogenesis Regulation Of Carbohydrate Metabolic Process Negative Regulation Of Protein Metabolic Process Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Skeletal Muscle Tissue Growth Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Skin Development Negative Regulation Of Cellular Component Movement Negative Regulation Of Locomotion Endocardial Cell Differentiation Mammary Gland Involution Developmental Growth Ossification Positive Regulation Of Signal Transduction Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Regulation Of Cell Proliferation Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Brainstem Development SMAD Protein Complex Assembly Regulation Of Cell Differentiation Regulation Of SMAD Protein Import Into Nucleus	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Hemostasis Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Fibrinolysis Platelet Activation Leukocyte Migration Positive Regulation Of Fibrinolysis Platelet Degranulation Response To Stimulus Proteolysis Fibrinolysis Exocrine Pancreas Development Regulation Of Blood Coagulation Response To Stress Regulation Of Protein Metabolic Process Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Anatomical Structure Morphogenesis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Wound Healing Prostate Gland Development Organ Morphogenesis Acute Inflammatory Response Vasculature Development Immune System Process Movement Of Cell Or Subcellular Component Factor XII Activation Cardiovascular System Development Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Processing Locomotion Cell Activation Regulation Of Mitotic Nuclear Division Prostate Gland Epithelium Morphogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis
Tagcloud ?			bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts
Tagcloud (Difference) ?			bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts
Tagcloud (Intersection) ?