PAPPA2

Description		pappalysin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Proteolysis Cell Surface Receptor Signaling Pathway Response To Salt Stress Bone Morphogenesis
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) Birth weight ( 31043758) Body mass index ( 26426971) Fractional exhaled nitric oxide (childhood) ( 24315451) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Height ( 25429064 20881960 31562340) Hip circumference adjusted for BMI ( 34021172) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Offspring birth weight ( 31043758) Pediatric central nervous system tumors (late onset)(pleiotropy) ( 33226468) Pediatric central nervous system tumors (pleiotropy) ( 33226468) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulse pressure ( 30578418 27841878) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		5 interacting genes: ATF7IP IGFBP3 IGFBP5 SMAD4 ZNF512B
Entrez ID		60676
HPRD ID		10156
Ensembl ID		ENSG00000116183
Uniprot IDs		Q9BXP8
PDB IDs		8SL1
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Insulin-like Growth Factor II Binding Osteoblast Differentiation Insulin-like Growth Factor Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor I Binding Type B Pancreatic Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Fibronectin Binding Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Muscle Hypertrophy Growth Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Regulation Of MiRNA Transcription Negative Regulation Of Skeletal Muscle Hypertrophy Regulation Of MiRNA Metabolic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Negative Regulation Of Protein Metabolic Process Regulation Of Growth Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Cell Population Proliferation Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Epithelial Cell Proliferation Protein Tyrosine Phosphatase Activator Activity Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Macromolecule Biosynthetic Process Carbohydrate Homeostasis Mammary Gland Involution Glucose Homeostasis Negative Regulation Of Biosynthetic Process Sulfate Binding Endocardial Cell Differentiation Regulation Of Primary Metabolic Process MAPK Cascade Negative Regulation Of Growth Regulation Of Muscle System Process Transcription Regulator Complex SMAD Protein Complex
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