PAPPA2

Gene Name		pappalysin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Intracellular Membrane Extracellular Vesicular Exosome
	Molecular Function	Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Regulation Of Cell Growth Proteolysis Cell Differentiation Cellular Protein Metabolic Process Bone Morphogenesis
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-protein Interactions		5 interactors: ATF7IP IGFBP3 IGFBP5 SMAD4 ZNF512B
Entrez ID		60676
HPRD ID		10156
Ensembl ID		ENSG00000116183
Uniprot IDs		Q9BXP8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Growth Regulation Of Smooth Muscle Cell Proliferation Regulation Of Glucose Metabolic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Cell Proliferation Cell Proliferation Negative Regulation Of Cellular Metabolic Process Osteoblast Differentiation Nephrogenic Mesenchyme Morphogenesis Regulation Of Carbohydrate Metabolic Process Negative Regulation Of Protein Metabolic Process Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Skeletal Muscle Tissue Growth Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Skin Development Negative Regulation Of Cellular Component Movement Negative Regulation Of Locomotion Endocardial Cell Differentiation Mammary Gland Involution Developmental Growth Ossification Positive Regulation Of Signal Transduction Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Regulation Of Cell Proliferation Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Brainstem Development SMAD Protein Complex Assembly Regulation Of Cell Differentiation Regulation Of SMAD Protein Import Into Nucleus
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