DROSHA

Gene Name		drosha, ribonuclease type III
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus
	Molecular Function	Lipopolysaccharide Binding Ribonuclease III Activity Protein Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Gene Expression MiRNA Metabolic Process RRNA Catabolic Process Primary MiRNA Processing Pre-miRNA Processing Ribosome Biogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of MiRNA Metabolic Process
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: DGCR8 SP1 ZNF512B
Entrez ID		29102
HPRD ID		10196
Ensembl ID		ENSG00000113360
Uniprot IDs		Q9NRR4
PDB IDs		2KHX
Enriched GO Terms of Interacting Partners?		Sequestering Of Nodal From Receptor Via Nodal Binding Negative Regulation Of Nodal Signaling Pathway Primary MiRNA Processing Determination Of Left/right Asymmetry In Lateral Mesoderm Regulation Of Nodal Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation By Host Of Viral Transcription Embryonic Process Involved In Female Pregnancy Lateral Mesoderm Development Enucleate Erythrocyte Differentiation Extracellular Negative Regulation Of Signal Transduction RNA Metabolic Process Atrial Septum Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Megakaryocyte Differentiation Regulation Of Activin Receptor Signaling Pathway Definitive Hemopoiesis Trophectodermal Cell Differentiation Gene Expression Interaction With Symbiont Gene Silencing By MiRNA Cellular Response To DsRNA Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Posttranscriptional Gene Silencing Negative Regulation Of BMP Signaling Pathway Embryonic Eye Morphogenesis Positive Regulation Of Viral Transcription Ventricular Septum Development Nucleobase-containing Compound Metabolic Process Embryonic Camera-type Eye Development Gene Silencing By RNA Determination Of Heart Left/right Asymmetry Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Viral Transcription Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Viral Process Response To DsRNA Cellular Nitrogen Compound Metabolic Process Cardiac Septum Development Regulation Of BMP Signaling Pathway Nitrogen Compound Metabolic Process Blastocyst Development Gene Silencing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Erythrocyte Differentiation
Tagcloud ?		alter bcac belongs casp8 causative combining consortium elucidate gwas hddc3 machinery meta micrornas mirna mustn1 mycl1 remaining risks rs1045494 rs1052532 rs10719 rs3134615 rs4687554 snps subgroups suggestive utr variations warranted