DROSHA and DGCR8

Number of citations of the paper that reports this interaction (PubMedID 36950067)
45

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology)
HPRD (in vitro)

		DROSHA	DGCR8
Description		drosha ribonuclease III	DGCR8 microprocessor complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Organelle Microprocessor Complex Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Nuclear Body Site Of Double-strand Break Microprocessor Complex Glutamatergic Synapse
	Molecular Function	Lipopolysaccharide Binding RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Ribonuclease III Activity Protein Binding Hydrolase Activity DEAD/H-box RNA Helicase Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding R-SMAD Binding Primary MiRNA Binding	RNA Binding Double-stranded RNA Binding Protein Binding Heme Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Primary MiRNA Binding Protein-RNA Adaptor Activity
	Biological Process	RRNA Processing RNA Processing Regulation Of Gene Expression MiRNA Metabolic Process Positive Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing Pre-miRNA Processing MiRNA Processing Ribosome Biogenesis Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Regulation Of MiRNA Metabolic Process	DNA Damage Response Primary MiRNA Processing Regulation Of Stem Cell Proliferation Positive Regulation Of Pre-miRNA Processing
Pathways		MicroRNA (miRNA) biogenesis	MicroRNA (miRNA) biogenesis Transcriptional Regulation by MECP2
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Height ( 33713608) Lung function (FEV1) ( 26635082) Tuberculosis ( 30713548)	Adult body size ( 32376654) Metabolite levels ( 23823483) Serum metabolite levels ( 23093944)
Interacting Genes		6 interacting genes: DGCR8 DYRK1A RNF10 SP1 TULP3 ZNF512B	6 interacting genes: APP DROSHA MEOX2 RNF10 RNF168 USP51
Entrez ID		29102	54487
HPRD ID		10196	09913
Ensembl ID		ENSG00000113360	ENSG00000128191
Uniprot IDs		Q9NRR4	Q8WYQ5
PDB IDs		2KHX 2NA2 5B16 6LXD 6LXE 6V5B 6V5C 9ASM 9ASN 9ASO 9ASP 9ASQ	1X47 2YT4 3LE4 5B16 6LXD 6LXE 6V5B 6V5C 7CNC 9ASM 9ASN 9ASO 9ASP 9ASQ
Enriched GO Terms of Interacting Partners?		Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Amyloid-beta Formation Regulation Of Amide Metabolic Process Regulation Of Gene Expression Histone H3T45 Kinase Activity Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Response To Wortmannin Bronchus Morphogenesis Microprocessor Complex Positive Regulation Of Pre-miRNA Processing Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Intraciliary Transport Particle A Binding Regulation Of RNA Metabolic Process Negative Regulation Of Heterochromatin Formation Regulation Of Metabolic Process Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Protein-RNA Adaptor Activity Positive Regulation Of MiRNA Processing Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Cellular Response To Zinc Ion Starvation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Regulation Of Heterochromatin Formation Neural Tube Formation Embryonic Neurocranium Morphogenesis Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Primary MiRNA Binding Rhythmic Process Transcription Cis-regulatory Region Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity 9+0 Non-motile Cilium Neurofilament Dorsal/ventral Neural Tube Patterning Positive Regulation Of MiRNA-mediated Gene Silencing Primary MiRNA Processing Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Development Regulation Of MiRNA Processing	Acetylcholine Receptor Activator Activity Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of MiRNA Metabolic Process Amylin Binding Regulation Of Macromolecule Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Lipoprotein Particle Regulation Of Cellular Response To Stress Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Microprocessor Complex Ribonuclease III Activity DNA Repair-dependent Chromatin Remodeling Histone Ubiquitin Ligase Activity Histone H2AK15 Ubiquitin Ligase Activity Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Metabolic Process Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Somite Specification Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane
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