DROSHA and DGCR8

Number of citations of the paper that reports this interaction (PMID 15574589)
351

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		DROSHA	DGCR8
Gene Name		drosha, ribonuclease type III	DGCR8 microprocessor complex subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Lipopolysaccharide Binding Ribonuclease III Activity Protein Binding Poly(A) RNA Binding Metal Ion Binding	Double-stranded RNA Binding Protein Binding Metal Ion Binding
	Biological Process	Gene Expression MiRNA Metabolic Process RRNA Catabolic Process Primary MiRNA Processing Pre-miRNA Processing Ribosome Biogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of MiRNA Metabolic Process	Gene Expression Primary MiRNA Processing Regulation Of Stem Cell Proliferation
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis	Regulatory RNA pathways MicroRNA (miRNA) biogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: DGCR8 SP1 ZNF512B	4 interactors: APP DROSHA MEOX2 SRPK1
Entrez ID		29102	54487
HPRD ID		10196	09913
Ensembl ID		ENSG00000113360	ENSG00000128191
Uniprot IDs		Q9NRR4	Q8WYQ5
PDB IDs		2KHX	1X47 2YT4 3LE4
Enriched GO Terms of Interacting Partners?		Sequestering Of Nodal From Receptor Via Nodal Binding Negative Regulation Of Nodal Signaling Pathway Primary MiRNA Processing Determination Of Left/right Asymmetry In Lateral Mesoderm Regulation Of Nodal Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation By Host Of Viral Transcription Embryonic Process Involved In Female Pregnancy Lateral Mesoderm Development Enucleate Erythrocyte Differentiation Extracellular Negative Regulation Of Signal Transduction RNA Metabolic Process Atrial Septum Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Megakaryocyte Differentiation Regulation Of Activin Receptor Signaling Pathway Definitive Hemopoiesis Trophectodermal Cell Differentiation Gene Expression Interaction With Symbiont Gene Silencing By MiRNA Cellular Response To DsRNA Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Posttranscriptional Gene Silencing Negative Regulation Of BMP Signaling Pathway Embryonic Eye Morphogenesis Positive Regulation Of Viral Transcription Ventricular Septum Development Nucleobase-containing Compound Metabolic Process Embryonic Camera-type Eye Development Gene Silencing By RNA Determination Of Heart Left/right Asymmetry Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Viral Transcription Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Viral Process Response To DsRNA Cellular Nitrogen Compound Metabolic Process Cardiac Septum Development Regulation Of BMP Signaling Pathway Nitrogen Compound Metabolic Process Blastocyst Development Gene Silencing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Erythrocyte Differentiation	Neuron Death RNA Processing Synaptic Growth At Neuromuscular Junction RNA Metabolic Process Gene Expression Collateral Sprouting In Absence Of Injury Defense Response Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Primary MiRNA Processing Somite Specification Axon Choice Point Recognition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Neuron Remodeling Sperm Chromatin Condensation RRNA Catabolic Process Regulation Of MiRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process MRNA Processing Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression MiRNA Metabolic Process Pre-miRNA Processing Segment Specification MRNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Viral Genome Replication Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Spermatid Nucleus Differentiation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Gene Silencing By MiRNA Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To DsRNA Defense Response To Gram-negative Bacterium RNA Polyadenylation Neuron Recognition Sexual Reproduction Posttranscriptional Gene Silencing
Tagcloud ?		alter bcac belongs casp8 causative combining consortium elucidate gwas hddc3 machinery meta micrornas mirna mustn1 mycl1 remaining risks rs1045494 rs1052532 rs10719 rs3134615 rs4687554 snps subgroups suggestive utr variations warranted	azoospermia biogenesis coding defects dicer1 dissect emphasize endo endonuclease fine germ haploid inactivation infertile infertility meiotic micro mirnas oligo retaining rnas sirnas spermatocyte spermatocytes spermatogenesis spermatozoa terato testicular tuning
Tagcloud (Difference) ?		alter bcac belongs casp8 causative combining consortium elucidate gwas hddc3 machinery meta micrornas mirna mustn1 mycl1 remaining risks rs1045494 rs1052532 rs10719 rs3134615 rs4687554 snps subgroups suggestive utr variations warranted	azoospermia biogenesis coding defects dicer1 dissect emphasize endo endonuclease fine germ haploid inactivation infertile infertility meiotic micro mirnas oligo retaining rnas sirnas spermatocyte spermatocytes spermatogenesis spermatozoa terato testicular tuning
Tagcloud (Intersection) ?