DROSHA and ZNF512B

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)

		DROSHA	ZNF512B
Gene Name		drosha, ribonuclease type III	zinc finger protein 512B
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleus
	Molecular Function	Lipopolysaccharide Binding Ribonuclease III Activity Protein Binding Poly(A) RNA Binding Metal Ion Binding	DNA Binding Metal Ion Binding
	Biological Process	Gene Expression MiRNA Metabolic Process RRNA Catabolic Process Primary MiRNA Processing Pre-miRNA Processing Ribosome Biogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of MiRNA Metabolic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: DGCR8 SP1 ZNF512B	60 interactors: ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BRD1 BTBD2 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FAM129B FHL3 GLRX3 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MYH10 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RPS27A SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2
Entrez ID		29102	57473
HPRD ID		10196	13840
Ensembl ID		ENSG00000113360	ENSG00000196700
Uniprot IDs		Q9NRR4	Q96KM6
PDB IDs		2KHX	2GQJ
Enriched GO Terms of Interacting Partners?		Sequestering Of Nodal From Receptor Via Nodal Binding Negative Regulation Of Nodal Signaling Pathway Primary MiRNA Processing Determination Of Left/right Asymmetry In Lateral Mesoderm Regulation Of Nodal Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation By Host Of Viral Transcription Embryonic Process Involved In Female Pregnancy Lateral Mesoderm Development Enucleate Erythrocyte Differentiation Extracellular Negative Regulation Of Signal Transduction RNA Metabolic Process Atrial Septum Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Megakaryocyte Differentiation Regulation Of Activin Receptor Signaling Pathway Definitive Hemopoiesis Trophectodermal Cell Differentiation Gene Expression Interaction With Symbiont Gene Silencing By MiRNA Cellular Response To DsRNA Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Posttranscriptional Gene Silencing Negative Regulation Of BMP Signaling Pathway Embryonic Eye Morphogenesis Positive Regulation Of Viral Transcription Ventricular Septum Development Nucleobase-containing Compound Metabolic Process Embryonic Camera-type Eye Development Gene Silencing By RNA Determination Of Heart Left/right Asymmetry Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Viral Transcription Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Viral Process Response To DsRNA Cellular Nitrogen Compound Metabolic Process Cardiac Septum Development Regulation Of BMP Signaling Pathway Nitrogen Compound Metabolic Process Blastocyst Development Gene Silencing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Erythrocyte Differentiation	Regulation Of Cellular Process Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organ Development System Development Transcription, DNA-templated Developmental Process Chromosome Organization Anatomical Structure Development Regulation Of Gene Expression RNA Biosynthetic Process Response To Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Biosynthetic Process Cell Cycle Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Cycle Process Multicellular Organismal Development Viral Genome Replication Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Wnt Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Chromatin Remodeling RNA Metabolic Process Primary MiRNA Processing Vesicle-mediated Transport Endosomal Transport Regulation Of Signal Transduction Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Gene Expression Response To Stress Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		alter bcac belongs casp8 causative combining consortium elucidate gwas hddc3 machinery meta micrornas mirna mustn1 mycl1 remaining risks rs1045494 rs1052532 rs10719 rs3134615 rs4687554 snps subgroups suggestive utr variations warranted
Tagcloud (Difference) ?		alter bcac belongs casp8 causative combining consortium elucidate gwas hddc3 machinery meta micrornas mirna mustn1 mycl1 remaining risks rs1045494 rs1052532 rs10719 rs3134615 rs4687554 snps subgroups suggestive utr variations warranted
Tagcloud (Intersection) ?