SCAF4 and WBP4

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		SCAF4	WBP4
Description		SR-related CTD associated factor 4	WW domain binding protein 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Nucleic Acid Binding RNA Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding
	Biological Process	Negative Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Apolipoprotein B levels ( 32203549) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol ( 30275531)	Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		3 interacting genes: CEBPA TP63 WBP4	66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207
Entrez ID		57466	11193
HPRD ID		11551	16086
Ensembl ID		ENSG00000156304	ENSG00000120688
Uniprot IDs		O95104	O75554
PDB IDs		6XKB	2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoblast Differentiation Stem Cell Proliferation Regulation Of Stem Cell Proliferation Notch Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Ectoderm And Mesoderm Interaction Epidermal Cell Division Regulation Of Osteoblast Differentiation Response To Vitamin B2 C/EBP Complex Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Protein Domain Specific Binding CHOP-C/EBP Complex RNA Metabolic Process Female Genitalia Morphogenesis Negative Regulation Of Mesoderm Development Regulation Of Epidermal Cell Division Transcription Cis-regulatory Region Binding White Fat Cell Proliferation Prostatic Bud Formation Gland Development Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Morphogenesis Of A Polarized Epithelium Response To Phenylpropanoid Regulation Of Mesoderm Development Response To Lithium Ion DNA-templated Transcription Transcription By RNA Polymerase I Urea Metabolic Process Sequence-specific DNA Binding Chromatin Binding Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific STAT Family Protein Binding Osteoblast Development Nucleic Acid Metabolic Process Fat Cell Proliferation Positive Regulation Of Fibroblast Apoptotic Process Genitalia Morphogenesis Skin Morphogenesis MDM2/MDM4 Family Protein Binding	MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding
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