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PTGS2 and CASK
Number of citations of the paper that reports this interaction (PubMedID
24722188
)
69
Data Source:
BioGRID
(two hybrid)
PTGS2
CASK
Description
prostaglandin-endoperoxide synthase 2
calcium/calmodulin dependent serine protein kinase
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Inner Membrane
Nuclear Outer Membrane
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Neuron Projection
Basement Membrane
Nucleus
Nuclear Lamina
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Basolateral Plasma Membrane
Nuclear Matrix
Cell Junction
Vesicle
Presynaptic Membrane
Synapse
Ciliary Membrane
Cell Periphery
Schaffer Collateral - CA1 Synapse
Molecular Function
Peroxidase Activity
Prostaglandin-endoperoxide Synthase Activity
Protein Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen
Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
Enzyme Binding
Heme Binding
Protein Homodimerization Activity
Metal Ion Binding
Dioxygenase Activity
Nucleotide Binding
GMP Kinase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Signaling Receptor Binding
Protein Binding
Calmodulin Binding
ATP Binding
Kinase Activity
Transferase Activity
Neurexin Family Protein Binding
Protein Serine Kinase Activity
Biological Process
Prostaglandin Biosynthetic Process
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Prostaglandin Metabolic Process
Response To Oxidative Stress
Embryo Implantation
Regulation Of Blood Pressure
Response To Nematode
Response To Selenium Ion
Positive Regulation Of Vascular Endothelial Growth Factor Production
Cyclooxygenase Pathway
Lipoxygenase Pathway
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Fever Generation
Prostaglandin Secretion
Regulation Of Cell Population Proliferation
Long-chain Fatty Acid Biosynthetic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Decidualization
Regulation Of Inflammatory Response
Brown Fat Cell Differentiation
Cellular Response To Hypoxia
Cellular Response To Non-ionic Osmotic Stress
Cellular Response To Fluid Shear Stress
Positive Regulation Of Transforming Growth Factor Beta Production
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Fibroblast Growth Factor Production
Positive Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of Platelet-derived Growth Factor Production
Cellular Oxidant Detoxification
Regulation Of Neuroinflammatory Response
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Negative Regulation Of Cell-matrix Adhesion
Cell Adhesion
Intracellular Protein Localization
Negative Regulation Of Keratinocyte Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
GMP Metabolic Process
GDP Metabolic Process
Regulation Of Neurotransmitter Secretion
Establishment Of Localization In Cell
Negative Regulation Of Wound Healing
Calcium Ion Import
Positive Regulation Of Calcium Ion Import
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Synaptic Vesicle Exocytosis
Pathways
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Biosynthesis of DHA-derived SPMs
Biosynthesis of EPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Dopamine Neurotransmitter Release Cycle
Syndecan interactions
Nephrin family interactions
Neurexins and neuroligins
Neurexins and neuroligins
Assembly and cell surface presentation of NMDA receptors
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
Drugs
Dihomo-gamma-linolenic acid
Icosapent
Aminosalicylic acid
Mesalazine
Acetaminophen
Indomethacin
Indomethacin
Nabumetone
Ketorolac
Tenoxicam
Lenalidomide
Celecoxib
Tolmetin
Rofecoxib
Piroxicam
Fenoprofen
Valdecoxib
Diclofenac
Sulindac
Flurbiprofen
Etodolac
Mefenamic acid
Naproxen
Sulfasalazine
Phenylbutazone
Meloxicam
Carprofen
Diflunisal
Suprofen
Salicylic acid
Meclofenamic acid
Acetylsalicylic acid
Bromfenac
Oxaprozin
Ketoprofen
Balsalazide
Ibuprofen
Lumiracoxib
Magnesium salicylate
Salsalate
Choline magnesium trisalicylate
Ginseng
Antrafenine
Antipyrine
Tiaprofenic acid
Etoricoxib
Flufenamic acid
Resveratrol
1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
Prostaglandin G2
Niflumic acid
Licofelone
Nimesulide
Cimicoxib
Lornoxicam
Aceclofenac
Nepafenac
Parecoxib
Pomalidomide
Cannabidiol
Loxoprofen
Dexibuprofen
Dexketoprofen
Droxicam
Tolfenamic acid
Firocoxib
Morniflumate
Propacetamol
Talniflumate
Phenyl salicylate
Trolamine salicylate
Menthyl salicylate
Glycol salicylate
Dipyrithione
Bryostatin 1
Alclofenac
Bufexamac
Bendazac
Acemetacin
Fish oil
Medical Cannabis
Nabiximols
Formic acid
Fostamatinib
Diseases
Esophageal cancer
Penile cancer
Cholangiocarcinoma
FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS
Crohn's disease (
26192919
)
Inflammatory bowel disease (
26192919
)
Knee osteoarthritis (
18471798
)
Interacting Genes
13 interacting genes:
ABHD16A
CASK
CAV1
CELF2
COPS5
COPS7A
CTNNB1
ELAVL1
GAS5
NUCB1
PTGIS
TP53
USP22
90 interacting genes:
AKAP9
APBA1
ATP2B4
BNIP3L
CADM1
CASKIN1
CDK9
CIMIP1
CNTNAP2
CNTNAP4
DDX54
DLG1
DLG4
DUSP3
ELL2
EPB41
EPS8
ERBIN
F11R
FCHSD2
FMR1
GCNT3
GLS2
GRIK2
GRIN2A
GTSE1
HGS
ID1
IL15RA
IL18
KCNA4
KCNJ12
KCNJ2
KCNJ4
KIF2A
KLC4
LIN7A
LIN7B
MAPRE1
MAPRE2
MARK2
MARS1
MED1
MLLT6
MLX
NDEL1
NPHS1
NRXN1
NRXN2
NRXN3
NTN4
P2RX7
PARD3B
PARD6G
PCBP2
PCM1
PKP2
PLK2
PPP4R3A
PRC1
PRKCI
PRKD2
PRKN
PRPF3
PTGS2
RAB3A
RBBP6
RBM10
RBM14
RBM5
RPA2
RPH3A
RSPH1
SDC1
SDC2
SDC3
SDC4
SF3B2
SH2D4A
SLAIN2
SRPK2
TANC1
TBR1
TIAM1
TRIM22
TSPYL2
UBC
WHRN
WNT7B
YWHAE
Entrez ID
5743
8573
HPRD ID
02599
02164
Ensembl ID
ENSG00000073756
ENSG00000147044
Uniprot IDs
P35354
A0A2R8YE77
A0A2U3TZM1
A0A7I2RJN6
O14936
PDB IDs
5F19
5F1A
5IKQ
5IKR
5IKT
5IKV
5KIR
1KGD
1KWA
1ZL8
3C0G
3C0H
3C0I
3MFR
3MFS
3MFT
3MFU
3TAC
6KMH
7OAI
7OAJ
7OAK
7OAL
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Nitric Oxide Biosynthetic Process
Enzyme Binding
Regulation Of Fibroblast Proliferation
Regulation Of Post-translational Protein Modification
Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA
Negative Regulation Of MiRNA-mediated Gene Silencing
Protein Deneddylation
Regulation Of Cellular Response To Growth Factor Stimulus
Apoptotic Signaling Pathway
MRNA 3'-UTR Binding
Positive Regulation Of Execution Phase Of Apoptosis
Regulation Of Protein Neddylation
Protein Modification By Small Protein Removal
Protein Neddylation
Glandular Epithelial Cell Differentiation
Disordered Domain Specific Binding
Regulation Of MiRNA-mediated Gene Silencing
Cellular Response To Oxygen Levels
Regulation Of Post-transcriptional Gene Silencing
Negative Regulation Of Fibroblast Proliferation
COP9 Signalosome
Regulation Of Programmed Necrotic Cell Death
Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Fibroblast Proliferation
Regulation Of Protein Metabolic Process
Regulation Of Cellular Response To Stress
Establishment Of Localization In Cell
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Calcium Ion Import
Regulation Of Neuroblast Proliferation
T Cell Differentiation In Thymus
Negative Regulation Of Gliogenesis
Neuroblast Proliferation
Positive Regulation Of Programmed Cell Death
Regulation Of Calcium Ion Transport
Negative Regulation Of Epithelial Cell Differentiation
Gastrulation
Inward Rectifier Potassium Channel Inhibitor Activity
Basolateral Plasma Membrane
Glial Cell Fate Determination
Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation
Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Autophagosome Size
Prostaglandin-I Synthase Activity
Negative Regulation Of Helicase Activity
Negative Regulation Of G1 To G0 Transition
Regulation Of RNA Metabolic Process
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Neuroligin Family Protein Binding
Glutamatergic Synapse
PDZ Domain Binding
Positive Regulation Of Cellular Component Organization
Regulation Of Cellular Component Organization
Establishment Or Maintenance Of Apical/basal Cell Polarity
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Synapse
Cell Projection
Microtubule-based Process
Intracellular Protein Localization
Regulation Of Membrane Potential
Positive Regulation Of Cellular Component Biogenesis
Vocalization Behavior
Neurotransmitter Secretion
Learning
Cellular Component Assembly
Protein Localization To Cell Junction
Social Behavior
Cell Adhesion
Presynaptic Membrane
Microtubule Cytoskeleton Organization
Protein Localization To Synapse
Regulation Of Cytoskeleton Organization
Cytoskeleton Organization
Chemical Synaptic Transmission
Neurotransmitter Transport
Regulation Of System Process
Cell-cell Junction
Regulation Of Transport
MPP7-DLG1-LIN7 Complex
Trans-synaptic Signaling
Learning Or Memory
Regulation Of Monoatomic Ion Transport
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Presynaptic Modulation Of Chemical Synaptic Transmission
Synaptic Signaling
Establishment Or Maintenance Of Cell Polarity
Signal Release
Regulation Of Exosomal Secretion
Regulation Of Multicellular Organismal Process
Voltage-gated Potassium Channel Complex
Postsynaptic Membrane
Plasma Membrane
Neuromuscular Junction
Presynapse
Protein Kinase Binding
Regulation Of Biological Quality
Bicellular Tight Junction
Protein Localization To Membrane
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Tagcloud (Intersection)
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