PTGS2 and PTGIS

Number of citations of the paper that reports this interaction (PMID 21035466)
4

Data Source:
BioGRID (fluorescent resonance energy transfer)

		PTGS2	PTGIS
Gene Name		prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	prostaglandin I2 (prostacyclin) synthase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Caveola Neuron Projection Protein Complex	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Lipid Binding Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding Arachidonate 15-lipoxygenase Activity	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding
	Biological Process	Prostaglandin Biosynthetic Process Angiogenesis Prostaglandin Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Movement Of Cell Or Subcellular Component Inflammatory Response Response To Oxidative Stress Embryo Implantation Learning Memory Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Response To Fructose Response To Manganese Ion Response To Lithium Ion Positive Regulation Vascular Endothelial Growth Factor Production Sensory Perception Of Pain Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Lipoxygenase Pathway NAD Metabolic Process Bone Mineralization Ovulation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Synaptic Plasticity Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Response To Lipopolysaccharide Response To Vitamin D Response To Tumor Necrosis Factor Cellular Response To UV Maintenance Of Blood-brain Barrier Positive Regulation Of NF-kappaB Import Into Nucleus Response To Drug Hair Cycle Positive Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Vasoconstriction Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Decidualization Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Oxidation-reduction Process Response To Fatty Acid Cellular Response To Mechanical Stimulus Cellular Response To ATP Cellular Response To Hypoxia Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Xenobiotic Metabolic Process Arachidonic Acid Metabolic Process Cyclooxygenase Pathway NAD Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Small Molecule Metabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Oxidation-reduction Process Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Arachidonic acid metabolism Defective AMN causes hereditary megaloblastic anemia 1 Nicotinamide salvaging Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Synthesis of 15-eicosatetraenoic acid derivatives Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism	Metabolism of vitamins and cofactors Bile acid and bile salt metabolism Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Metabolic disorders of biological oxidation enzymes Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Arachidonic acid metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Endogenous sterols Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 24-hydroxycholesterol Defective GIF causes intrinsic factor deficiency Defective FMO3 causes Trimethylaminuria (TMAU) Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Eicosanoids Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Defective MAOA causes Brunner syndrome (BRUNS) Defects in biotin (Btn) metabolism Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Defective TCN2 causes hereditary megaloblastic anemia Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Cytochrome P450 - arranged by substrate type Nicotinamide salvaging Biological oxidations Sterols are 12-hydroxylated by CYP8B1 Defects in cobalamin (B12) metabolism Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective CYP1B1 causes Glaucoma Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Nicotinate metabolism Defects in vitamin and cofactor metabolism
Drugs		gamma-Homolinolenic acid Icosapent Aminosalicylic Acid Mesalazine Acetaminophen Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicyclic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Thalidomide Ibuprofen Lumiracoxib Magnesium salicylate Salicylate-sodium Salsalate Trisalicylate-choline Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic Acid Resveratrol Heme 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic Acid Nimesulide Lornoxicam Nepafenac Pomalidomide	Phenylbutazone Epoprostenol (6E)-7-{6-[(1E)-OCT-1-ENYL]-2,3-DIAZABICYCLO[2.2.1]HEPT-2-EN-5-YL}HEPT-6-ENOIC ACID
Diseases
GWAS		Knee osteoarthritis ( 18471798)
Protein-Protein Interactions		11 interactors: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 NUCB1 PTGIS TP53	3 interactors: APP PTGS1 PTGS2
Entrez ID		5743	5740
HPRD ID		02599	09046
Ensembl ID		ENSG00000073756	ENSG00000124212
Uniprot IDs		P35354	Q16647
PDB IDs		1V0X	2IAG 3B6H
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Reactive Oxygen Species Metabolic Process Cullin Deneddylation Protein Deneddylation Cellular Response To Oxygen Levels Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Calcium Ion Import Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Calcium Ion Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Ischemia Positive Regulation Of Cell Death Negative Regulation Of Cell Proliferation Regulation Of Neuroblast Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Epithelial Cell Proliferation Response To Hypoxia Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Lactation Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Reactive Oxygen Species Biosynthetic Process Apoptotic Signaling Pathway Positive Regulation Of Histone Modification Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ion Transmembrane Transport Cell Death Protein Oligomerization Death Canonical Wnt Signaling Pathway Positive Regulation Of Calcium Ion Transport Vasculogenesis Response To Abiotic Stimulus Regulation Of Fibroblast Proliferation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Macromitophagy Negative Regulation Of Mitotic Cell Cycle, Embryonic	Cyclooxygenase Pathway Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Response To Oxidative Stress Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Learning Maintenance Of Blood-brain Barrier Lipid Metabolic Process Regulation Of Blood Pressure Defense Response Synaptic Growth At Neuromuscular Junction Positive Regulation Of Fibroblast Growth Factor Production Collateral Sprouting In Absence Of Injury Learning Or Memory Cognition Positive Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Synaptic Transmission, Dopaminergic Nicotinamide Metabolic Process Blood Circulation Fatty Acid Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Response To Light Stimulus Positive Regulation Of Brown Fat Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Axon Choice Point Recognition Positive Regulation Of Prostaglandin Biosynthetic Process Inflammatory Response Small Molecule Metabolic Process Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Synaptic Plasticity Response To Radiation Single-organism Behavior Neuron Remodeling Cellular Response To ATP Response To Fructose Positive Regulation Of Fever Generation Regulation Of Cellular Ketone Metabolic Process Alkaloid Metabolic Process Regulation Of Fever Generation Positive Regulation Of Heat Generation Lipoxygenase Pathway
Tagcloud ?		20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation foxo3 infiltrating let lungs mir mirna orchestrating participating pertaining poisoning runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb	amputation boosting candidates computational concordant cryoinjury datasets failing fate heart hearts highlights integrative periostin players promises property qpcr ranked regeneration remarkable reproducible specification top unbiased usp2a validations verified zebrafish
Tagcloud (Difference) ?		20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation foxo3 infiltrating let lungs mir mirna orchestrating participating pertaining poisoning runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb	amputation boosting candidates computational concordant cryoinjury datasets failing fate heart hearts highlights integrative periostin players promises property qpcr ranked regeneration remarkable reproducible specification top unbiased usp2a validations verified zebrafish
Tagcloud (Intersection) ?