PTGS2 and NUCB1

Number of citations of the paper that reports this interaction (PubMedID 18493301)
47

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (two hybrid, in vitro)

		PTGS2	NUCB1
Description		prostaglandin-endoperoxide synthase 2	nucleobindin 1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Neuron Projection	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System Membrane Extracellular Exosome
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Response To Oxidative Stress Embryo Implantation Regulation Of Blood Pressure Response To Nematode Response To Selenium Ion Positive Regulation Of Vascular Endothelial Growth Factor Production Cyclooxygenase Pathway Lipoxygenase Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Prostaglandin Secretion Regulation Of Cell Population Proliferation Long-chain Fatty Acid Biosynthetic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Decidualization Regulation Of Inflammatory Response Brown Fat Cell Differentiation Cellular Response To Hypoxia Cellular Response To Non-ionic Osmotic Stress Cellular Response To Fluid Shear Stress Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress	Small GTPase-mediated Signal Transduction
Pathways		Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Dihomo-gamma-linolenic acid Icosapent Aminosalicylic acid Mesalazine Acetaminophen Indomethacin Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Firocoxib Morniflumate Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Dipyrithione Bryostatin 1 Alclofenac Bufexamac Bendazac Acemetacin Fish oil Medical Cannabis Nabiximols	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Esophageal cancer Penile cancer Cholangiocarcinoma
GWAS		Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798)
Interacting Genes		13 interacting genes: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22	18 interacting genes: DYRK1A GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 HOXA1 MYC NDN PTGS1 PTGS2 RBL1 REL SET SIRPA XPO1
Entrez ID		5743	4924
HPRD ID		02599	03205
Ensembl ID		ENSG00000073756	ENSG00000104805
Uniprot IDs		P35354	A8K7Q1 Q02818
PDB IDs		5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR	1SNL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nitric Oxide Biosynthetic Process Enzyme Binding Regulation Of Fibroblast Proliferation Regulation Of Post-translational Protein Modification Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Protein Deneddylation Regulation Of Cellular Response To Growth Factor Stimulus Apoptotic Signaling Pathway MRNA 3'-UTR Binding Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Neddylation Protein Modification By Small Protein Removal Protein Neddylation Glandular Epithelial Cell Differentiation Disordered Domain Specific Binding Regulation Of MiRNA-mediated Gene Silencing Cellular Response To Oxygen Levels Regulation Of Post-transcriptional Gene Silencing Negative Regulation Of Fibroblast Proliferation COP9 Signalosome Regulation Of Programmed Necrotic Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Fibroblast Proliferation Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Telomere Maintenance Via Telomerase Regulation Of Calcium Ion Import Regulation Of Neuroblast Proliferation T Cell Differentiation In Thymus Negative Regulation Of Gliogenesis Neuroblast Proliferation Positive Regulation Of Programmed Cell Death Regulation Of Calcium Ion Transport Negative Regulation Of Epithelial Cell Differentiation Gastrulation Inward Rectifier Potassium Channel Inhibitor Activity Basolateral Plasma Membrane Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Autophagosome Size Prostaglandin-I Synthase Activity Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of RNA Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Binding Mu-type Opioid Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway GTP Binding Cyclooxygenase Pathway Prostaglandin-endoperoxide Synthase Activity Adenylate Cyclase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion By Cell Regulation Of Insulin Secretion Negative Regulation Of Secretion Positive Regulation Of Metabolic Process Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion G Protein Activity Negative Regulation Of Protein Secretion Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Negative Regulation Of Transport Dioxygenase Activity Regulation Of Protein Transport Cell Body Negative Regulation Of Cell Communication Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Interferon-beta Production Prostaglandin Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Regulation Of Protein Secretion Prostanoid Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Macromolecule Biosynthetic Process G Protein-coupled Dopamine Receptor Signaling Pathway Protein-DNA Complex Disassembly Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Transport Regulation Of Secretion By Cell Response To Prostaglandin E
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