PTGS2 and CAV1

Number of citations of the paper that reports this interaction (PubMedID 37676109)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		PTGS2	CAV1
Description		prostaglandin-endoperoxide synthase 2	caveolin 1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Neuron Projection	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity	Signaling Receptor Binding Patched Binding Protein Binding Oxysterol Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Nitric-oxide Synthase Inhibitor Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Protein Heterodimerization Activity Nitric-oxide Synthase Binding ATPase Binding Molecular Adaptor Activity Inward Rectifier Potassium Channel Inhibitor Activity Protein Sequestering Activity
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Response To Oxidative Stress Embryo Implantation Regulation Of Blood Pressure Response To Nematode Response To Selenium Ion Positive Regulation Of Vascular Endothelial Growth Factor Production Cyclooxygenase Pathway Lipoxygenase Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Prostaglandin Secretion Regulation Of Cell Population Proliferation Long-chain Fatty Acid Biosynthetic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Decidualization Regulation Of Inflammatory Response Brown Fat Cell Differentiation Cellular Response To Hypoxia Cellular Response To Non-ionic Osmotic Stress Cellular Response To Fluid Shear Stress Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Angiogenesis Vasculogenesis Response To Hypoxia Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of The Force Of Heart Contraction Glandular Epithelial Cell Differentiation Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Nitric Oxide Biosynthetic Process Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of Calcium Ion Transport Into Cytosol Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cholesterol Efflux Protein Transport Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Fatty Acid Metabolic Process Cytokine-mediated Signaling Pathway Lipid Storage Cell Differentiation Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Maintenance Of Protein Location In Cell Response To Progesterone Intracellular Nitric Oxide Homeostasis Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Insulin Receptor Internalization Angiotensin-activated Signaling Pathway Vasoconstriction Cholesterol Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Response To Estrogen Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Nitric Oxide Metabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Muscle Cell Cellular Homeostasis Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Pinocytosis Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Establishment Of Localization In Cell Membrane Depolarization Calcium Ion Homeostasis Mammary Gland Involution Canonical Wnt Signaling Pathway Negative Regulation Of Necroptotic Process Caveola Assembly Cellular Response To Misfolded Protein Cellular Response To Peptide Hormone Stimulus Cellular Response To Hyperoxia Cellular Response To Transforming Growth Factor Beta Stimulus Basement Membrane Organization Caveolin-mediated Endocytosis Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Cold-induced Thermogenesis Regulation Of Ruffle Assembly Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Localization To Basolateral Plasma Membrane Positive Regulation Of Gap Junction Assembly Positive Regulation Of ERAD Pathway Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	Triglyceride catabolism eNOS activation NOSTRIN mediated eNOS trafficking Thyroxine biosynthesis Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle FOXO-mediated transcription of cell cycle genes RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs		Dihomo-gamma-linolenic acid Icosapent Aminosalicylic acid Mesalazine Acetaminophen Indomethacin Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Firocoxib Morniflumate Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Dipyrithione Bryostatin 1 Alclofenac Bufexamac Bendazac Acemetacin Fish oil Medical Cannabis Nabiximols
Diseases		Esophageal cancer Penile cancer Cholangiocarcinoma	Congenital generalized lipodystrophy (CGL)
GWAS		Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798)	Atrial fibrillation ( 33990960 22544366 30061737 29892015 28416822) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 25173105 29891935 33627673 20835238) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 29235454 25173106 28073927 29617998) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) P wave duration ( 28794112) Platelet distribution width ( 32888494) PR interval ( 20062060 25035420 32439900 30679814 23139255 30046033 29127183) PR segment duration ( 24850809) Proportion of activated microglia (inferior temporal cortex) ( 30679421) QRS duration ( 30012220) QT interval ( 29874175 24952745) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		13 interacting genes: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22	86 interacting genes: ABCB1 ABL1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DANCR DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FYN GJA1 GJA3 GJB2 GLP1R GNAI2 GRB7 GRK1 GRK2 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KCNA3 KDR LRP1 MALL MAPK1 MAPK3 MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TEK TGFBR1 TNFRSF1B TRAF2 TRAF4 TRAF6 TRPC1 USP7 VAV2
Entrez ID		5743	857
HPRD ID		02599	03028
Ensembl ID		ENSG00000073756	ENSG00000105974
Uniprot IDs		P35354	A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3
PDB IDs		5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR	7SC0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nitric Oxide Biosynthetic Process Enzyme Binding Regulation Of Fibroblast Proliferation Regulation Of Post-translational Protein Modification Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Protein Deneddylation Regulation Of Cellular Response To Growth Factor Stimulus Apoptotic Signaling Pathway MRNA 3'-UTR Binding Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Neddylation Protein Modification By Small Protein Removal Protein Neddylation Glandular Epithelial Cell Differentiation Disordered Domain Specific Binding Regulation Of MiRNA-mediated Gene Silencing Cellular Response To Oxygen Levels Regulation Of Post-transcriptional Gene Silencing Negative Regulation Of Fibroblast Proliferation COP9 Signalosome Regulation Of Programmed Necrotic Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Fibroblast Proliferation Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Telomere Maintenance Via Telomerase Regulation Of Calcium Ion Import Regulation Of Neuroblast Proliferation T Cell Differentiation In Thymus Negative Regulation Of Gliogenesis Neuroblast Proliferation Positive Regulation Of Programmed Cell Death Regulation Of Calcium Ion Transport Negative Regulation Of Epithelial Cell Differentiation Gastrulation Inward Rectifier Potassium Channel Inhibitor Activity Basolateral Plasma Membrane Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Autophagosome Size Prostaglandin-I Synthase Activity Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of RNA Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Signal Transduction Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Membrane Raft Regulation Of Cellular Component Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Oxygen-containing Compound Regulation Of Programmed Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Biological Quality Kinase Activity Protein Phosphorylation Regulation Of Transport Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Cell Death Membrane Anatomical Structure Morphogenesis Phosphorylation Receptor Complex Regulation Of ERK1 And ERK2 Cascade
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