VARS2 and SORBS3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		VARS2	SORBS3
Gene Name		valyl-tRNA synthetase 2, mitochondrial	sorbin and SH3 domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Aminoacyl-tRNA Editing Activity Valine-tRNA Ligase Activity ATP Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Valyl-tRNA Aminoacylation Regulation Of Translational Fidelity Gene Expression	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		tRNA Aminoacylation Mitochondrial tRNA aminoacylation	Smooth Muscle Contraction
Drugs
Diseases
GWAS		HIV-1 control ( 20041166) Pubertal anthropometrics ( 23449627) Ulcerative colitis ( 20848476)	HIV-1 control ( 20205591)
Protein-Protein Interactions		6 interactors: ABI2 CMTM5 MAL2 NCK2 PIK3CA SORBS3	46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		57176	10174
HPRD ID		11670	11535
Ensembl ID		ENSG00000137411	ENSG00000120896
Uniprot IDs		B4E0K6 Q5ST30	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytoskeleton Organization Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Locomotion Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament-based Process Regulation Of Peptidyl-serine Phosphorylation Hypomethylation Of CpG Island Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cell Migration Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Motility Regulation Of Organelle Organization Positive Regulation Of T Cell Activation Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Homotypic Cell-cell Adhesion Muscle Contraction Cytoskeleton Organization Positive Regulation Of Cell-cell Adhesion Regulation Of Genetic Imprinting Muscle System Process Regulation Of T Cell Activation Regulation Of Phosphorylation Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cell Activation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Actin Nucleation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Negative Regulation Of Fibroblast Apoptotic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Signal Complex Assembly Negative Regulation Of Anoikis Regulation Of Cell Activation Regulation Of Anoikis Regulation Of DNA Methylation Regulation Of Cellular Ketone Metabolic Process Rac Protein Signal Transduction Regulation Of Fibroblast Apoptotic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Cellular Component Organization	Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process
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