VARS2

Description		valyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Aminoacyl-tRNA Ligase Activity Valine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Valyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Pathways		Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Conotruncal heart defects (maternal effects) ( 28468790) Gestational age at birth (maternal effect) ( 28877031) HIV-1 control ( 20041166) Malaria ( 31844061) Microalbuminuria in type 1 diabetes ( 31537649) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 20848476) Urate levels ( 31578528)
Interacting Genes		8 interacting genes: ABI1 ABI2 ABI3 CMTM5 MAL2 NCK2 PIK3CA SORBS3
Entrez ID		57176
HPRD ID		11670
Ensembl ID		ENSG00000137411
Uniprot IDs		A0A1U9X9B3 B4DG77 B4E0K6 Q5ST30
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin-based Cell Projection SCAR Complex Signaling Adaptor Activity Regulation Of Lamellipodium Assembly Lamellipodium Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cell Migration Filopodium Tip Neuron Migration Cell Motility Cytoskeletal Anchor Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Positive Regulation Of Lamellipodium Organization Regulation Of Cell Projection Assembly Regulation Of Dendritic Spine Morphogenesis Postsynaptic Density Actin Filament Organization Lamellipodium Organization Cell Projection Morphogenesis Peptidyl-tyrosine Phosphorylation Actin Polymerization Or Depolymerization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Filopodium Cytoskeleton Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Zonula Adherens Assembly Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization SH3 Domain Binding Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Organelle Organization Response To Butyrate Cellular Response To Hydrostatic Pressure Regulation Of Actin Polymerization Or Depolymerization Phosphatidylinositol 3-kinase Complex, Class IB Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Regulation Of Postsynapse Organization Regulation Of Actin Filament Length Dendritic Spine
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