VARS2 and ABI2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		VARS2	ABI2
Gene Name		valyl-tRNA synthetase 2, mitochondrial	abl-interactor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol	Cytoplasm Cytosol Cytoskeleton Lamellipodium Filopodium SCAR Complex
	Molecular Function	Aminoacyl-tRNA Editing Activity Valine-tRNA Ligase Activity ATP Binding	DNA Binding Protein Binding Cytoskeletal Adaptor Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Rac GTPase Binding Proline-rich Region Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Valyl-tRNA Aminoacylation Regulation Of Translational Fidelity Gene Expression	Movement Of Cell Or Subcellular Component Cytoskeleton Organization Actin Polymerization Or Depolymerization Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		tRNA Aminoacylation Mitochondrial tRNA aminoacylation	Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		HIV-1 control ( 20041166) Pubertal anthropometrics ( 23449627) Ulcerative colitis ( 20848476)	Butyrylcholinesterase levels ( 21862451) Subclinical atherosclerosis traits (other) ( 17903303)
Protein-Protein Interactions		6 interactors: ABI2 CMTM5 MAL2 NCK2 PIK3CA SORBS3	57 interactors: ABL1 ADAM19 AES ARHGAP32 ARMC7 BLOC1S6 CCDC102B CCDC36 CCDC53 CCHCR1 CDK6 CRX DTNB EFS EGLN3 EIF3H ENAH GCC1 HGS HNRNPK HOMER3 IFT20 KHDRBS1 KIAA1217 KIFC3 KRT13 KRT15 KRT19 KRT20 KRT31 KRT33B LMO2 MRFAP1L1 MRPL44 NCK2 NUP62 PCM1 PIN1 PPIF PRAM1 PRKAA1 PRKAA2 PRR16 SDCBP SH3KBP1 SNAP23 STAM2 TFIP11 TRAF3IP1 TRIM32 TRIP6 VARS2 VASP VCL VPS37C WASF2 WIPF1
Entrez ID		57176	10152
HPRD ID		11670	07338
Ensembl ID		ENSG00000137411	ENSG00000138443
Uniprot IDs		B4E0K6 Q5ST30	E9PEZ7 Q9NYB9
PDB IDs			2ED0 3P8C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytoskeleton Organization Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Locomotion Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Actin Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament-based Process Regulation Of Peptidyl-serine Phosphorylation Hypomethylation Of CpG Island Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cell Migration Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Motility Regulation Of Organelle Organization Positive Regulation Of T Cell Activation Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Homotypic Cell-cell Adhesion Muscle Contraction Cytoskeleton Organization Positive Regulation Of Cell-cell Adhesion Regulation Of Genetic Imprinting Muscle System Process Regulation Of T Cell Activation Regulation Of Phosphorylation Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cell Activation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Actin Nucleation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Negative Regulation Of Fibroblast Apoptotic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Signal Complex Assembly Negative Regulation Of Anoikis Regulation Of Cell Activation Regulation Of Anoikis Regulation Of DNA Methylation Regulation Of Cellular Ketone Metabolic Process Rac Protein Signal Transduction Regulation Of Fibroblast Apoptotic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Cellular Component Organization	Intracellular Transport Organelle Organization Cell Projection Assembly Establishment Of Localization In Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Response To Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Cytoskeleton Organization Negative Regulation Of Signaling Cellular Localization Cellular Component Assembly Regulation Of Signal Transduction Cell Projection Morphogenesis Cellular Response To Stimulus Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Cell Cycle Arrest Cell Projection Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Actin Cytoskeleton Organization System Development Actin Filament-based Process Anatomical Structure Development Signaling Intraciliary Transport Cell Morphogenesis Membrane Organization Generation Of Neurons Cell Communication Regulation Of Autophagy Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development Protein Localization Protein Transport Neurogenesis Lamellipodium Assembly Signal Transduction Lamellipodium Organization Establishment Of Protein Localization Negative Regulation Of Cellular Senescence Microtubule-based Transport
Tagcloud ?			aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana
Tagcloud (Difference) ?			aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana
Tagcloud (Intersection) ?