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VARS2 and PIK3CA
Number of citations of the paper that reports this interaction (PMID
18624398
)
4
Data Source:
BioGRID
(two hybrid)
VARS2
PIK3CA
Gene Name
valyl-tRNA synthetase 2, mitochondrial
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Mitochondrion
Cytosol
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Lamellipodium
Molecular Function
Aminoacyl-tRNA Editing Activity
Valine-tRNA Ligase Activity
ATP Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Protein Kinase Activator Activity
Phosphatidylinositol 3-kinase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Insulin Receptor Substrate Binding
Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Biological Process
TRNA Aminoacylation For Protein Translation
Valyl-tRNA Aminoacylation
Regulation Of Translational Fidelity
Gene Expression
Angiogenesis
Vasculature Development
Glucose Metabolic Process
Protein Phosphorylation
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Epidermal Growth Factor Receptor Signaling Pathway
Blood Coagulation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Platelet Activation
T Cell Costimulation
Positive Regulation Of Peptidyl-serine Phosphorylation
Phosphatidylinositol-3-phosphate Biosynthetic Process
Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Multicellular Organism Growth
Protein Kinase B Signaling
Negative Regulation Of Neuron Apoptotic Process
Endothelial Cell Migration
Hypomethylation Of CpG Island
Small Molecule Metabolic Process
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Phosphatidylinositol Phosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
Leukocyte Migration
Cardiac Muscle Contraction
Negative Regulation Of Fibroblast Apoptotic Process
Regulation Of Genetic Imprinting
Negative Regulation Of Anoikis
Pathways
tRNA Aminoacylation
Mitochondrial tRNA aminoacylation
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Metabolism of lipids and lipoproteins
Signaling by FGFR in disease
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Interleukin receptor SHC signaling
PI-3K cascade
Gastrin-CREB signalling pathway via PKC and MAPK
Signaling by FGFR1 mutants
Role of phospholipids in phagocytosis
Phospholipid metabolism
Fcgamma receptor (FCGR) dependent phagocytosis
PI3K Cascade
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
G-protein beta:gamma signalling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
G alpha (q) signalling events
Signaling by ERBB2
Signaling by EGFR
GPCR downstream signaling
TCR signaling
Signaling by Interleukins
Signaling by VEGF
Downstream signal transduction
Signaling by FGFR mutants
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Nephrin interactions
Interleukin-2 signaling
PI3K/AKT Signaling in Cancer
Platelet activation, signaling and aggregation
Interleukin-3, 5 and GM-CSF signaling
Adaptive Immune System
G alpha (q) signalling events
Downstream TCR signaling
Costimulation by the CD28 family
IRS-mediated signalling
PIP3 activates AKT signaling
IGF1R signaling cascade
VEGFA-VEGFR2 Pathway
Synthesis of PIPs at the plasma membrane
IRS-related events triggered by IGF1R
G beta:gamma signalling through PI3Kgamma
PI3K events in ERBB2 signaling
Regulation of signaling by CBL
Downstream signaling of activated FGFR
G alpha (12/13) signalling events
PI Metabolism
Innate Immune System
Signaling by Insulin receptor
Signalling by NGF
Insulin receptor signalling cascade
Signaling by Ligand-Responsive EGFR Variants in Cancer
IRS-related events
Cytokine Signaling in Immune system
NGF signalling via TRKA from the plasma membrane
Tie2 Signaling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Cell surface interactions at the vascular wall
Signaling by FGFR
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
GPVI-mediated activation cascade
Interleukin receptor SHC signaling
Signaling by FGFR1 fusion mutants
Constitutive Signaling by EGFRvIII
PI3K Cascade
Drugs
Diseases
GWAS
HIV-1 control (
20041166
)
Pubertal anthropometrics (
23449627
)
Ulcerative colitis (
20848476
)
Protein-Protein Interactions
6 interactors:
ABI2
CMTM5
MAL2
NCK2
PIK3CA
SORBS3
43 interactors:
ADAP1
AMBP
APLP2
APPL1
ATPIF1
ATR
DDX5
DNAJB6
FASLG
FTL
GABRB1
GNAQ
GRIN2B
HRAS
IL3
IRS2
IRS4
ITIH1
KRAS
LCK
MRAS
NEDD9
NRAS
PDE4D
PDGFRB
PIK3R1
PIK3R3
PRKCD
RASD2
RASGRP3
RPS20
RPS6KB1
SGK1
SH3KBP1
SLC9A3R1
SLC9A3R2
SMAD2
SMAD3
SQSTM1
STAT1
TICAM1
UFD1L
VARS2
Entrez ID
57176
5290
HPRD ID
11670
01382
Ensembl ID
ENSG00000137411
Uniprot IDs
B4E0K6
Q5ST30
P42336
PDB IDs
2ENQ
2RD0
3HHM
3HIZ
3ZIM
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cytoskeleton Organization
Actin Filament Organization
Regulation Of Actin Cytoskeleton Organization
Locomotion
Positive Regulation Of Organelle Organization
Regulation Of Actin Filament-based Process
Regulation Of Cytoskeleton Organization
Actin Cytoskeleton Organization
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Actin Filament-based Process
Regulation Of Peptidyl-serine Phosphorylation
Hypomethylation Of CpG Island
Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Cell Migration
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cell Motility
Regulation Of Organelle Organization
Positive Regulation Of T Cell Activation
Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase
Positive Regulation Of Homotypic Cell-cell Adhesion
Muscle Contraction
Cytoskeleton Organization
Positive Regulation Of Cell-cell Adhesion
Regulation Of Genetic Imprinting
Muscle System Process
Regulation Of T Cell Activation
Regulation Of Phosphorylation
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Positive Regulation Of Cell Activation
Positive Regulation Of Cellular Component Biogenesis
Positive Regulation Of Actin Nucleation
Regulation Of Phosphorus Metabolic Process
Movement Of Cell Or Subcellular Component
Negative Regulation Of Fibroblast Apoptotic Process
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Regulation Of Cellular Amino Acid Metabolic Process
Signal Complex Assembly
Negative Regulation Of Anoikis
Regulation Of Cell Activation
Regulation Of Anoikis
Regulation Of DNA Methylation
Regulation Of Cellular Ketone Metabolic Process
Rac Protein Signal Transduction
Regulation Of Fibroblast Apoptotic Process
Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Phosphatidylinositol-3-phosphate Biosynthetic Process
Regulation Of Cellular Component Organization
Regulation Of Signal Transduction
Regulation Of Signaling
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Signaling
Regulation Of Intracellular Signal Transduction
Cell Communication
Cellular Response To Organonitrogen Compound
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Cellular Response To Insulin Stimulus
Cellular Response To Peptide Hormone Stimulus
Insulin Receptor Signaling Pathway
Cellular Response To Peptide
Regulation Of Catalytic Activity
Cellular Response To Organic Substance
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Phosphorus Metabolic Process
Response To Growth Factor
Regulation Of Phosphorylation
Response To Organic Substance
Regulation Of Cell Death
Apoptotic Process
Response To Insulin
Intracellular Signal Transduction
Programmed Cell Death
Neurotrophin TRK Receptor Signaling Pathway
Cell Death
Death
Neurotrophin Signaling Pathway
Regulation Of Cell Proliferation
Cellular Response To Growth Factor Stimulus
Response To Peptide Hormone
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Peptide
Regulation Of Metabolic Process
Response To Organonitrogen Compound
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Cellular Process
Response To Fibroblast Growth Factor
Regulation Of Immune Response
Response To Stimulus
Cellular Response To Hormone Stimulus
Immune Response-regulating Signaling Pathway
Tagcloud
?
amplified
biomarker
e542k
e545d
e545k
embedded
fixed
formalin
h1047l
h1047r
homolog
metastatic
namely
next
oncogenic
paraffin
phospho
phosphoinositol
pi3k
pras40thr246
proline
pten
reflect
refractory
respond
retrospectively
tensin
trastuzumab
unlikely
Tagcloud (Difference)
?
amplified
biomarker
e542k
e545d
e545k
embedded
fixed
formalin
h1047l
h1047r
homolog
metastatic
namely
next
oncogenic
paraffin
phospho
phosphoinositol
pi3k
pras40thr246
proline
pten
reflect
refractory
respond
retrospectively
tensin
trastuzumab
unlikely
Tagcloud (Intersection)
?