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PELI2 and IRAK4
Number of citations of the paper that reports this interaction (PubMedID
17675297
)
0
Data Source:
HPRD
(in vivo)
PELI2
IRAK4
Description
pellino E3 ubiquitin protein ligase family member 2
interleukin 1 receptor associated kinase 4
Image
GO Annotations
Cellular Component
Cytosol
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell Surface
Endosome Membrane
Extrinsic Component Of Plasma Membrane
Molecular Function
Protein Binding
Transferase Activity
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Interleukin-1 Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Serine Kinase Activity
Biological Process
Protein Polyubiquitination
Positive Regulation Of Protein Phosphorylation
Regulation Of Toll Signaling Pathway
Protein Ubiquitination
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of MAPK Cascade
Toll-like Receptor Signaling Pathway
Immune System Process
Neutrophil Mediated Immunity
MyD88-dependent Toll-like Receptor Signaling Pathway
Signal Transduction
JNK Cascade
Toll Signaling Pathway
Cytokine-mediated Signaling Pathway
Positive Regulation Of Defense Response
Lipopolysaccharide-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Intracellular Signal Transduction
Non-canonical NF-kappaB Signal Transduction
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of Smooth Muscle Cell Proliferation
Interleukin-1-mediated Signaling Pathway
Neutrophil Migration
Pathways
Interleukin-1 signaling
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
IRAK4 deficiency (TLR5)
IRAK4 deficiency (TLR2/4)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE
Fostamatinib
Diseases
Defects of toll-like receptor signaling, including the following disease: Il-1 receptor-associated kinase 4 (IRAK-4) deficiency
GWAS
Adverse response to chemotherapy (amenorrhea) in breast cancer (
31371054
)
Body mass index (smoking years interaction) (
23192594
)
Body mass index (ever vs never smoking interaction) (
23192594
)
Chronic obstructive pulmonary disease-related biomarkers (
23144326
)
End-stage kidney disease (
31178898
)
Height (
25133637
)
Nickel levels (
26025379
)
Telomere length (
21460395
)
Immune reponse to smallpox (secreted TNF-alpha) (
22610502
)
Inflammatory bowel disease (
27569725
)
Interacting Genes
44 interacting genes:
BCL10
CEP170B
CLEC17A
CREB3L3
DEAF1
ERO1A
FN1
FRYL
HNRNPK
HYAL2
IRAK1
IRAK2
IRAK4
IRS1
LAMC3
LTBP3
LZTFL1
MDFI
MEOX1
MPDZ
MYD88
MYO10
NEK9
NUP62
OR7D2
PCGF2
PICALM
PRR36
RABEP1
RBBP8
REL
RMDN3
RNF220
SEPTIN3
SP4
SRPK1
TGM2
THAP7
TMEM79
TP53
TP63
TRIM32
UBQLN4
YTHDF2
22 interacting genes:
ARNT
EIF4EBP1
H1-1
H1-2
H1-3
H1-4
H1-5
H1-6
IKBKG
IL36RN
IRAK1
MBP
MYD88
PELI1
PELI2
PELI3
TBPL1
TICAM2
TIRAP
TRAF6
TRIM7
ZNF597
Entrez ID
57161
51135
HPRD ID
17835
06051
Ensembl ID
ENSG00000139946
ENSG00000198001
Uniprot IDs
Q9H716
Q9HAT8
B2RAP9
B4E359
Q69FE3
Q9NWZ3
PDB IDs
3EGA
3EGB
2NRU
2NRY
2O8Y
2OIB
2OIC
2OID
3MOP
4RMZ
4U97
4U9A
4XS2
4Y73
4YO6
4YP8
4ZTL
4ZTM
4ZTN
5K72
5K75
5K76
5K7G
5K7I
5KX7
5KX8
5T1S
5T1T
5UIQ
5UIR
5UIS
5UIT
5UIU
5W84
5W85
6EG9
6EGA
6EGD
6EGE
6EGF
6F3D
6F3E
6F3G
6F3I
6LXY
6MOM
6N8G
6O8U
6O94
6O95
6O9D
6RFI
6RFJ
6THW
6THX
6THZ
6TI8
6TIA
6UYA
6VQL
7C2V
7C2W
7QG1
7QG2
7QG3
7QG5
8ATB
8ATL
8ATN
8BR5
8BR6
8BR7
8DKS
8SCE
8SCV
8SCW
8TVM
8TVN
8TX0
8UCB
8UCC
8V1O
8V2F
8V2L
8W3W
8W3X
8WTF
Enriched GO Terms of Interacting Partners
?
Toll Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Lipopolysaccharide-mediated Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Identical Protein Binding
Toll-like Receptor Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
General Transcription Initiation Factor Binding
Positive Regulation Of Intracellular Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Innate Immune Response-activating Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin
Activation Of Innate Immune Response
Positive Regulation Of Defense Response
Regulation Of Signal Transduction
Regulation Of Primary Metabolic Process
Endolysosomal Toll-like Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Signaling Adaptor Activity
Anatomical Structure Morphogenesis
Regulation Of Apoptotic Signaling Pathway
Response To Interleukin-1
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Defense Response
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Response To Stress
Regulation Of Cell Communication
Cellular Developmental Process
Regulation Of Signaling
Regulation Of Gene Expression
Positive Regulation Of DNA-binding Transcription Factor Activity
Chromosome Condensation
Nucleosomal DNA Binding
Negative Regulation Of DNA Recombination
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of DNA Recombination
Chromatin DNA Binding
Structural Constituent Of Chromatin
Toll-like Receptor 4 Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Nucleosome Assembly
Cell Surface Pattern Recognition Receptor Signaling Pathway
Nucleosome
Euchromatin
Nucleosome Organization
Double-stranded DNA Binding
Negative Regulation Of DNA Metabolic Process
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Regulation Of Toll Signaling Pathway
Signaling Adaptor Activity
Regulation Of Macromolecule Metabolic Process
Innate Immune Response
Response To Lipopolysaccharide
Interleukin-33-mediated Signaling Pathway
Regulation Of Toll-like Receptor 4 Signaling Pathway
Protein-DNA Complex Assembly
Cellular Response To Molecule Of Bacterial Origin
Response To Molecule Of Bacterial Origin
Positive Regulation Of Cytokine Production
Defense Response To Symbiont
Defense Response To Other Organism
Regulation Of Metabolic Process
Regulation Of Cytokine Production
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Type I Interferon Production
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Ubiquitin-ubiquitin Ligase Activity
Immune Response
Positive Regulation Of Gene Expression
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Interleukin-6 Production
Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Positive Regulation Of Chemokine Production
Regulation Of DNA Metabolic Process
Response To External Biotic Stimulus
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