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PELI2
Gene Name
pellino E3 ubiquitin protein ligase family member 2
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Molecular Function
Protein Binding
Ligase Activity
Biological Process
Positive Regulation Of Protein Phosphorylation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll Signaling Pathway
Protein Ubiquitination
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Innate Immune Response
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cytokine Signaling in Immune system
Toll Like Receptor TLR6:TLR2 Cascade
IRAK1 recruits IKK complex
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
Signaling by Interleukins
Toll-Like Receptors Cascades
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 5 (TLR5) Cascade
Toll Like Receptor 4 (TLR4) Cascade
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Interleukin-1 signaling
Toll Like Receptor 9 (TLR9) Cascade
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK1 recruits IKK complex
Innate Immune System
Drugs
Diseases
GWAS
Body mass index (interaction) (
23192594
)
Chronic obstructive pulmonary disease-related biomarkers (
23144326
)
Telomere length (
21460395
)
Protein-protein Interactions
17 interactors:
BCL10
CREB3L3
DEAF1
ERO1L
FN1
FRYL
HNRNPK
IRAK1
IRAK2
IRAK4
LAMC3
LTBP3
MYD88
PICALM
SRPK1
THAP7
UBQLN4
Entrez ID
57161
HPRD ID
17835
Ensembl ID
ENSG00000139946
Uniprot IDs
Q9H716
Q9HAT8
PDB IDs
3EGA
3EGB
Enriched GO Terms of Interacting Partners
?
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Positive Regulation Of Innate Immune Response
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
JNK Cascade
Regulation Of Innate Immune Response
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Defense Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cytokine Production
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Immune Response-regulating Signaling Pathway
MAPK Cascade
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cellular Metabolic Process
Response To Stress
Response To Interleukin-1
Response To Peptidoglycan
Regulation Of RNA Metabolic Process
Signal Transduction By Phosphorylation
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Smooth Muscle Cell Proliferation
Immune System Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Immune Response
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Response To Molecule Of Bacterial Origin
Interleukin-1-mediated Signaling Pathway
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Extracellular Matrix Organization
Extracellular Structure Organization
Cytokine Biosynthetic Process
Positive Regulation Of Peptidase Activity
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