IRAK4 and MYD88

Number of citations of the paper that reports this interaction (PubMedID 11960013)
27

Data Source:
HPRD (in vivo, in vitro)

		IRAK4	MYD88
Description		interleukin 1 receptor associated kinase 4	MYD88 innate immune signal transduction adaptor
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Endosome Membrane Extrinsic Component Of Plasma Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Endosome Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity	Signaling Receptor Binding Toll Binding Death Receptor Binding Cytokine Receptor Binding Interleukin-1 Receptor Binding Protein Binding Toll-like Receptor Binding Signaling Adaptor Activity Identical Protein Binding Molecular Adaptor Activity TIR Domain Binding ATP-dependent Histone Chaperone Activity
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Neutrophil Mediated Immunity MyD88-dependent Toll-like Receptor Signaling Pathway Signal Transduction JNK Cascade Toll Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Interleukin-1-mediated Signaling Pathway Neutrophil Migration	Response To Molecule Of Fungal Origin Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Chromatin Organization Chromatin Remodeling Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway JNK Cascade Toll Signaling Pathway Response To Virus Induced Systemic Resistance Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Microglia Differentiation Response To Amine Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Neurogenesis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Peptidoglycan Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 8 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Interleukin-33-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Skin Development Innate Immune Response Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Neutrophil-mediated Killing Of Bacterium Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Establishment Of Endothelial Intestinal Barrier Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Neutrophil Migration Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs		1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE Fostamatinib
Diseases		Defects of toll-like receptor signaling, including the following disease: Il-1 receptor-associated kinase 4 (IRAK-4) deficiency
GWAS		Immune reponse to smallpox (secreted TNF-alpha) ( 22610502) Inflammatory bowel disease ( 27569725)	Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)
Interacting Genes		22 interacting genes: ARNT EIF4EBP1 H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 IKBKG IL36RN IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6 TRIM7 ZNF597	44 interacting genes: BTK CD93 CISH FADD FLII IKBKG IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 NTAQ1 PELI2 PFKL POLR1C PRDX1 RAC1 RNF152 RNF4 SARM1 SIAH2 SMAD3 SPOP SPOPL STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7 ZNF35
Entrez ID		51135	4615
HPRD ID		06051	03703
Ensembl ID		ENSG00000198001	ENSG00000172936
Uniprot IDs		B2RAP9 B4E359 Q69FE3 Q9NWZ3	A0A0A0MSI9 A0A3B3ITY3 A0A3F2YP85 A0A494C0J8 Q99836
PDB IDs		2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP 4RMZ 4U97 4U9A 4XS2 4Y73 4YO6 4YP8 4ZTL 4ZTM 4ZTN 5K72 5K75 5K76 5K7G 5K7I 5KX7 5KX8 5T1S 5T1T 5UIQ 5UIR 5UIS 5UIT 5UIU 5W84 5W85 6EG9 6EGA 6EGD 6EGE 6EGF 6F3D 6F3E 6F3G 6F3I 6LXY 6MOM 6N8G 6O8U 6O94 6O95 6O9D 6RFI 6RFJ 6THW 6THX 6THZ 6TI8 6TIA 6UYA 6VQL 7C2V 7C2W 7QG1 7QG2 7QG3 7QG5 8ATB 8ATL 8ATN 8BR5 8BR6 8BR7 8DKS 8SCE 8SCV 8SCW 8TVM 8TVN 8TX0 8UCB 8UCC 8V1O 8V2F 8V2L 8W3W 8W3X 8WTF	2JS7 2Z5V 3MOP 4DOM 4EO7 6I3N 7BEQ 7BER 7L6W 8S78 8W8M
Enriched GO Terms of Interacting Partners?		Chromosome Condensation Nucleosomal DNA Binding Negative Regulation Of DNA Recombination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA Recombination Chromatin DNA Binding Structural Constituent Of Chromatin Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Nucleosome Assembly Cell Surface Pattern Recognition Receptor Signaling Pathway Nucleosome Euchromatin Nucleosome Organization Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Toll Signaling Pathway Signaling Adaptor Activity Regulation Of Macromolecule Metabolic Process Innate Immune Response Response To Lipopolysaccharide Interleukin-33-mediated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Protein-DNA Complex Assembly Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Production Defense Response To Symbiont Defense Response To Other Organism Regulation Of Metabolic Process Regulation Of Cytokine Production Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Immune Response Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-6 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Chemokine Production Regulation Of DNA Metabolic Process Response To External Biotic Stimulus	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Defense Response Positive Regulation Of Cytokine Production Regulation Of Immune Response Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Defense Response To Other Organism Positive Regulation Of Immune Response Defense Response Positive Regulation Of Gene Expression Regulation Of Cytokine Production Response To Other Organism Defense Response To Symbiont Response To External Biotic Stimulus Positive Regulation Of Immune System Process Immune System Process Immune Response Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Signal Transduction Regulation Of Interferon-beta Production Inflammatory Response Positive Regulation Of Interleukin-8 Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Interferon-beta Production Cell Surface Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of Interferon-alpha Production Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-8 Production Interleukin-1-mediated Signaling Pathway
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