IRAK4 and HIST1H1T

Number of citations of the paper that reports this interaction (PMID 15927069)
0

Data Source:
BioGRID (enzymatic study)

		IRAK4	HIST1H1T
Gene Name		interleukin-1 receptor-associated kinase 4	histone cluster 1, H1t
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane	Nucleosome Condensed Nuclear Chromosome Nucleus
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding	DNA Binding
	Biological Process	Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation JNK Cascade Cytokine-mediated Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation	Nucleosome Assembly Multicellular Organismal Development Spermatogenesis Binding Of Sperm To Zona Pellucida Cell Differentiation Sperm Motility
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Interleukin-1 signaling Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Innate Immune System
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted TNF-alpha) ( 22610502)
Protein-Protein Interactions		18 interactors: ARNT EIF4EBP1 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H1T IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6	2 interactors: IRAK4 PRKCA
Entrez ID		51135	3010
HPRD ID		06051	00822
Ensembl ID		ENSG00000198001	ENSG00000187475
Uniprot IDs		B2RAP9 B4E359 Q69FE3 Q9NWZ3	P22492
PDB IDs		2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nucleosome Assembly Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Chromatin Assembly Nucleosome Organization Toll-like Receptor 9 Signaling Pathway Response To Bacterium Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Cytokine Production DNA Packaging Positive Regulation Of Cytokine Production Positive Regulation Of Immune System Process Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Nucleosome Positioning Response To Other Organism Immune Response-regulating Signaling Pathway Response To Biotic Stimulus DNA Conformation Change Positive Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Regulation Of Immune System Process Defense Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Immune Response Protein Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Lymphocyte Proliferation Response To Lipid	Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Response To Cytokine Positive Regulation Of Macrophage Differentiation Desmosome Organization Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Immune System Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Platelet Activation Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Positive Regulation Of Signal Transduction Mitotic Nuclear Envelope Disassembly Positive Regulation Of Adenylate Cyclase Activity Immune Response Regulation Of Immune System Process Protein Phosphorylation Defense Response Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Nucleotide Metabolic Process Histone Phosphorylation Nuclear Envelope Disassembly Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Lyase Activity Peptidyl-threonine Phosphorylation Regulation Of Cell Proliferation Activation Of Phospholipase C Activity Neutrophil Chemotaxis Positive Regulation Of Myeloid Leukocyte Differentiation
Tagcloud ?		curated degeneracy degenerative districts dysbiosis emerge experimentally gi gut interactomes microbiome mtx multi nitrogenous omic pathogens picture ppi properly recollects recommendation run screens silico simulation synovial topological usage warn
Tagcloud (Difference) ?		curated degeneracy degenerative districts dysbiosis emerge experimentally gi gut interactomes microbiome mtx multi nitrogenous omic pathogens picture ppi properly recollects recommendation run screens silico simulation synovial topological usage warn
Tagcloud (Intersection) ?