IRAK4 and H1-5

Number of citations of the paper that reports this interaction (PubMedID 15927069)
19

Data Source:
BioGRID (enzymatic study)

		IRAK4	H1-5
Description		interleukin 1 receptor associated kinase 4	H1.5 linker histone, cluster member
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GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Endosome Membrane Extrinsic Component Of Plasma Membrane	Chromatin Nucleosome Euchromatin Heterochromatin Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Neutrophil Mediated Immunity MyD88-dependent Toll-like Receptor Signaling Pathway Signal Transduction JNK Cascade Toll Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Interleukin-1-mediated Signaling Pathway Neutrophil Migration	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Muscle Organ Development Chromosome Condensation Negative Regulation Of DNA Recombination Protein Stabilization Establishment Of Protein Localization To Chromatin
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE Fostamatinib
Diseases		Defects of toll-like receptor signaling, including the following disease: Il-1 receptor-associated kinase 4 (IRAK-4) deficiency
GWAS		Immune reponse to smallpox (secreted TNF-alpha) ( 22610502) Inflammatory bowel disease ( 27569725)
Interacting Genes		22 interacting genes: ARNT EIF4EBP1 H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 IKBKG IL36RN IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6 TRIM7 ZNF597	32 interacting genes: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDC42 CDK1 CDK2 CDK5 CDKN1A CDKN1B CEBPA EHMT2 HPF1 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PARP1 PARP2 PRKCA PRKCB PRKCD PRKCZ RIPK3 RPS6KA5 SERPINH1 SIRT1
Entrez ID		51135	3009
HPRD ID		06051	00821
Ensembl ID		ENSG00000198001	ENSG00000184357
Uniprot IDs		B2RAP9 B4E359 Q69FE3 Q9NWZ3	P16401
PDB IDs		2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP 4RMZ 4U97 4U9A 4XS2 4Y73 4YO6 4YP8 4ZTL 4ZTM 4ZTN 5K72 5K75 5K76 5K7G 5K7I 5KX7 5KX8 5T1S 5T1T 5UIQ 5UIR 5UIS 5UIT 5UIU 5W84 5W85 6EG9 6EGA 6EGD 6EGE 6EGF 6F3D 6F3E 6F3G 6F3I 6LXY 6MOM 6N8G 6O8U 6O94 6O95 6O9D 6RFI 6RFJ 6THW 6THX 6THZ 6TI8 6TIA 6UYA 6VQL 7C2V 7C2W 7QG1 7QG2 7QG3 7QG5 8ATB 8ATL 8ATN 8BR5 8BR6 8BR7 8DKS 8SCE 8SCV 8SCW 8TVM 8TVN 8TX0 8UCB 8UCC 8V1O 8V2F 8V2L 8W3W 8W3X 8WTF	2RHI
Enriched GO Terms of Interacting Partners?		Chromosome Condensation Nucleosomal DNA Binding Negative Regulation Of DNA Recombination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA Recombination Chromatin DNA Binding Structural Constituent Of Chromatin Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Nucleosome Assembly Cell Surface Pattern Recognition Receptor Signaling Pathway Nucleosome Euchromatin Nucleosome Organization Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Toll Signaling Pathway Signaling Adaptor Activity Regulation Of Macromolecule Metabolic Process Innate Immune Response Response To Lipopolysaccharide Interleukin-33-mediated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Protein-DNA Complex Assembly Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Production Defense Response To Symbiont Defense Response To Other Organism Regulation Of Metabolic Process Regulation Of Cytokine Production Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Immune Response Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-6 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Chemokine Production Regulation Of DNA Metabolic Process Response To External Biotic Stimulus	Chromatin Remodeling Protein Modification Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Serine Kinase Activity Chromatin Binding Protein Serine/threonine Kinase Activity Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Nucleoplasm Regulation Of DNA Metabolic Process Protein Kinase Activity Regulation Of Cell Cycle Cellular Response To Oxygen-containing Compound Cellular Response To Stress Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Macromolecule Biosynthetic Process Response To Stress Nucleus Protein Kinase Binding Cyclin A2-CDK2 Complex Negative Regulation Of Macromolecule Biosynthetic Process Protein Phosphorylation Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Intracellular Signal Transduction Phosphorylation Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Positive Regulation Of DNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of RNA Metabolic Process Cell Cycle G2/M Phase Transition
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