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PELI2 and IRAK2
Number of citations of the paper that reports this interaction (PMID
17675297
)
17
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
PELI2
IRAK2
Gene Name
pellino E3 ubiquitin protein ligase family member 2
interleukin-1 receptor-associated kinase 2
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Interleukin-1 Receptor Complex
Molecular Function
Protein Binding
Ligase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Biological Process
Positive Regulation Of Protein Phosphorylation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll Signaling Pathway
Protein Ubiquitination
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAPK Cascade
Innate Immune Response
Activation Of MAPK Activity
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cytokine Signaling in Immune system
Toll Like Receptor TLR6:TLR2 Cascade
IRAK1 recruits IKK complex
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
Signaling by Interleukins
Toll-Like Receptors Cascades
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 5 (TLR5) Cascade
Toll Like Receptor 4 (TLR4) Cascade
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Interleukin-1 signaling
Toll Like Receptor 9 (TLR9) Cascade
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK1 recruits IKK complex
Innate Immune System
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
activated TAK1 mediates p38 MAPK activation
Innate Immune System
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
IRAK2 mediated activation of TAK1 complex
IRAK2 mediated activation of TAK1 complex
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
Cytokine Signaling in Immune system
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Signaling by Interleukins
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Interleukin-1 signaling
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Body mass index (interaction) (
23192594
)
Chronic obstructive pulmonary disease-related biomarkers (
23144326
)
Telomere length (
21460395
)
Protein-Protein Interactions
17 interactors:
BCL10
CREB3L3
DEAF1
ERO1L
FN1
FRYL
HNRNPK
IRAK1
IRAK2
IRAK4
LAMC3
LTBP3
MYD88
PICALM
SRPK1
THAP7
UBQLN4
20 interactors:
ARAF
HRAS
IL1R1
IRAK1
IRAK3
MYD88
PELI1
PELI2
PELI3
SARM1
SMAD2
SMURF1
STT3A
TARDBP
TICAM2
TIRAP
TLR4
TOLLIP
TRAF6
ZC3H12A
Entrez ID
57161
3656
HPRD ID
17835
04491
Ensembl ID
ENSG00000139946
ENSG00000134070
Uniprot IDs
Q9H716
Q9HAT8
O43187
PDB IDs
3EGA
3EGB
3MOP
Enriched GO Terms of Interacting Partners
?
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Positive Regulation Of Innate Immune Response
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
JNK Cascade
Regulation Of Innate Immune Response
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Defense Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cytokine Production
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Immune Response-regulating Signaling Pathway
MAPK Cascade
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cellular Metabolic Process
Response To Stress
Response To Interleukin-1
Response To Peptidoglycan
Regulation Of RNA Metabolic Process
Signal Transduction By Phosphorylation
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Smooth Muscle Cell Proliferation
Immune System Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Immune Response
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Response To Molecule Of Bacterial Origin
Interleukin-1-mediated Signaling Pathway
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Extracellular Matrix Organization
Extracellular Structure Organization
Cytokine Biosynthetic Process
Positive Regulation Of Peptidase Activity
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Toll-like Receptor 4 Signaling Pathway
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Innate Immune Response
Immune Response-regulating Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Lipopolysaccharide
Response To Bacterium
Regulation Of Interleukin-6 Production
Regulation Of Immune System Process
Response To Molecule Of Bacterial Origin
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Positive Regulation Of Immune Response
Cellular Response To Molecule Of Bacterial Origin
Toll Signaling Pathway
Immune Response
Response To Other Organism
Defense Response
Interleukin-1-mediated Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Response To Biotic Stimulus
Regulation Of Cytokine Production
Positive Regulation Of Intracellular Signal Transduction
Response To Lipid
Regulation Of Signaling
Cellular Response To Stimulus
Response To Organic Substance
Positive Regulation Of NF-kappaB Transcription Factor Activity
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Positive Regulation Of Signal Transduction
Immune System Process
Toll-like Receptor 9 Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Interleukin-6 Production
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Cellular Response To Lipopolysaccharide
Signal Transduction
Tagcloud
?
adapter
bmdm
bmdms
catalytically
corrected
d359a
e525a
hardly
il10
il6
irak1
knock
limiting
modest
myd88
pdcs
plasmacytoid
secretion
sustain
tlr
tlr4
tlr7
tlr9
tnfa
tnfr
toll
traf6
trif
Tagcloud (Difference)
?
adapter
bmdm
bmdms
catalytically
corrected
d359a
e525a
hardly
il10
il6
irak1
knock
limiting
modest
myd88
pdcs
plasmacytoid
secretion
sustain
tlr
tlr4
tlr7
tlr9
tnfa
tnfr
toll
traf6
trif
Tagcloud (Intersection)
?