PELI2 and NEK9

Number of citations of the paper that reports this interaction (PubMedID 34674267)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		PELI2	NEK9
Description		pellino E3 ubiquitin protein ligase family member 2	NIMA related kinase 9
Image
GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Centrosome Cytosol
	Molecular Function	Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade	Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		44 interacting genes: BCL10 CEP170B CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 IRS1 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MPDZ MYD88 MYO10 NEK9 NUP62 OR7D2 PCGF2 PICALM PRR36 RABEP1 RBBP8 REL RMDN3 RNF220 SEPTIN3 SP4 SRPK1 TGM2 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4 YTHDF2	16 interacting genes: BICD2 CSN2 GABARAP MAP1LC3A MAP1LC3B MBP NEK6 NEK7 NEK8 PELI2 RAN SSRP1 SUPT16H TTN UBC WEE2-AS1
Entrez ID		57161	91754
HPRD ID		17835	11386
Ensembl ID		ENSG00000139946	ENSG00000119638
Uniprot IDs		Q9H716 Q9HAT8	A0A7I2V454 A0A7I2V5R1 Q6PKF2 Q8TD19
PDB IDs		3EGA 3EGB	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Toll Signaling Pathway Non-canonical NF-kappaB Signal Transduction Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process General Transcription Initiation Factor Binding Positive Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response-activating Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Activation Of Innate Immune Response Positive Regulation Of Defense Response Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Endolysosomal Toll-like Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Adaptor Activity Anatomical Structure Morphogenesis Regulation Of Apoptotic Signaling Pathway Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Defense Response Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Response To Stress Regulation Of Cell Communication Cellular Developmental Process Regulation Of Signaling Regulation Of Gene Expression Positive Regulation Of DNA-binding Transcription Factor Activity	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein-containing Complex Disassembly FACT Complex Organelle Assembly Autophagosome Maturation Ubiquitin Protein Ligase Binding Autophagosome Membrane Mitophagy Structural Constituent Of Myelin Sheath Microtubule Protein Serine Kinase Activity Autophagy Of Mitochondrion Autophagosome Protein Serine/threonine Kinase Activity Cellular Component Assembly Autophagosome Assembly Nucleosome Disassembly Microtubule Cytoskeleton Organization Protein-DNA Complex Disassembly Autophagosome Organization Endomembrane System Protein-containing Complex Organization Protein Kinase Activity Phospholipid Binding Cytoskeleton Microtubule-based Process Nucleosome Binding Positive Regulation Of Metalloendopeptidase Activity Protein Localization To Myelin Sheath Abaxonal Region DRM Complex Macroautophagy Spindle Organization Kinase Activity Pyroptotic Inflammatory Response Organelle Membrane Vacuole Organization
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