PELI2 and LAMC3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PELI2	LAMC3
Gene Name		pellino E3 ubiquitin protein ligase family member 2	laminin, gamma 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Membrane
	Molecular Function	Protein Binding Ligase Activity	Structural Molecule Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll Signaling Pathway Protein Ubiquitination Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response	Cell Morphogenesis Involved In Differentiation Cell Adhesion Visual Perception Astrocyte Development Extracellular Matrix Organization Retina Development In Camera-type Eye
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Interleukin-1 signaling Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK1 recruits IKK complex Innate Immune System	Laminin interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Telomere length ( 21460395)
Protein-Protein Interactions		17 interactors: BCL10 CREB3L3 DEAF1 ERO1L FN1 FRYL HNRNPK IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 MYD88 PICALM SRPK1 THAP7 UBQLN4	20 interactors: ANXA5 CFB CRP CSNK2A2 CWC25 CYP2E1 EPB41L4B FRAT1 HP KIF1C LGMN NR1H2 PELI2 POT1 RPL35 SERPINA3 SLC43A3 TF YTHDC1 ZNF160
Entrez ID		57161	10319
HPRD ID		17835	05069
Ensembl ID		ENSG00000139946	ENSG00000050555
Uniprot IDs		Q9H716 Q9HAT8	Q8N2D6 Q9Y6N6
PDB IDs		3EGA 3EGB
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway JNK Cascade Regulation Of Innate Immune Response Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Signaling Pathway MAPK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Interleukin-1 Response To Peptidoglycan Regulation Of RNA Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Interleukin-1-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cytokine Biosynthetic Process Positive Regulation Of Peptidase Activity	Acute-phase Response Acute Inflammatory Response Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Protein Processing Defense Response Regulation Of Immune Response Regulation Of Macrophage Derived Foam Cell Differentiation Response To Stress Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of DNA Strand Elongation Negative Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Lipid Storage Regulation Of Innate Immune Response Positive Regulation Of Immune Response Negative Regulation Of Chromosome Organization Regulation Of High-density Lipoprotein Particle Assembly Telomere Formation Via Telomerase Negative Regulation Of Proteolysis Regulation Of Immune System Process Negative Regulation Of Protein Processing Negative Regulation Of Catalytic Activity Negative Regulation Of Pinocytosis Negative Regulation Of Hydrogen Peroxide Metabolic Process
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