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IRAK4 and ARNT
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
IRAK4
ARNT
Description
interleukin 1 receptor associated kinase 4
aryl hydrocarbon receptor nuclear translocator
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell Surface
Endosome Membrane
Extrinsic Component Of Plasma Membrane
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Nuclear Body
Aryl Hydrocarbon Receptor Complex
Nuclear Aryl Hydrocarbon Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Interleukin-1 Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Serine Kinase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Aryl Hydrocarbon Receptor Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Toll-like Receptor Signaling Pathway
Immune System Process
Neutrophil Mediated Immunity
MyD88-dependent Toll-like Receptor Signaling Pathway
Signal Transduction
JNK Cascade
Toll Signaling Pathway
Cytokine-mediated Signaling Pathway
Positive Regulation Of Defense Response
Lipopolysaccharide-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Intracellular Signal Transduction
Non-canonical NF-kappaB Signal Transduction
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of Smooth Muscle Cell Proliferation
Interleukin-1-mediated Signaling Pathway
Neutrophil Migration
Response To Hypoxia
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Vascular Endothelial Growth Factor Production
Cell Differentiation
Intracellular Receptor Signaling Pathway
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Sumoylation
Cellular Response To Oxidative Stress
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Biosynthetic Process
Negative Regulation Of Inflammatory Response
Intestinal Epithelial Structure Maintenance
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
IRAK4 deficiency (TLR5)
IRAK4 deficiency (TLR2/4)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Regulation of gene expression by Hypoxia-inducible Factor
PPARA activates gene expression
Phase I - Functionalization of compounds
Endogenous sterols
Xenobiotics
Aryl hydrocarbon receptor signalling
NPAS4 regulates expression of target genes
NPAS4 regulates expression of target genes
Drugs
1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE
Fostamatinib
Diseases
Defects of toll-like receptor signaling, including the following disease: Il-1 receptor-associated kinase 4 (IRAK-4) deficiency
GWAS
Immune reponse to smallpox (secreted TNF-alpha) (
22610502
)
Inflammatory bowel disease (
27569725
)
Body mass index (
26426971
)
Congenital left-sided heart lesions (
26965164
)
Cutaneous squamous cell carcinoma (
32041948
)
Estimated glomerular filtration rate (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Fasting glucose (
34059833
)
Hip circumference adjusted for BMI (
34021172
)
Melanoma (
21983785
28212542
)
Metabolic syndrome (
31589552
)
Platelet count (
32888494
)
Rhegmatogenous retinal detachment (
23585552
)
Tea consumption (
31046077
)
Urate levels (
23263486
)
Interacting Genes
22 interacting genes:
ARNT
EIF4EBP1
H1-1
H1-2
H1-3
H1-4
H1-5
H1-6
IKBKG
IL36RN
IRAK1
MBP
MYD88
PELI1
PELI2
PELI3
TBPL1
TICAM2
TIRAP
TRAF6
TRIM7
ZNF597
78 interacting genes:
ADH5
AHR
AHRR
AIP
AKT1
ARL14
ARNT2
BECN1
BRCA1
CALCOCO1
CASP3
CASP9
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CLOCK
CSNK2A1
DIABLO
EP300
EPAS1
EPHA2
ERBB2
ESR1
FGFR4
FZR1
GLIS1
GLIS2
GMNN
GTF2F1
GTF2F2
HEY1
HEY2
HGF
HIF1A
HIF3A
HNF4A
IRAK4
KPNA1
KPNA3
KPNA5
KPNA6
LATS2
LSM8
MAP2K5
MAPK14
MTA3
MYC
NCOA1
NCOA2
NCOA7
NCOR2
NF2
NPAS2
NPAS4
PDGFRA
PML
PTGES3
RAF1
RELA
SENP6
SIM1
SIM2
SMAD9
SP1
STK11
STRBP
TACC3
TEAD2
TGM2
TNFAIP1
TRIP11
TUBB2A
UBE2I
Entrez ID
51135
405
HPRD ID
06051
00524
Ensembl ID
ENSG00000198001
ENSG00000143437
Uniprot IDs
B2RAP9
B4E359
Q69FE3
Q9NWZ3
A8K6P0
B0AZM1
P27540
Q53F30
PDB IDs
2NRU
2NRY
2O8Y
2OIB
2OIC
2OID
3MOP
4RMZ
4U97
4U9A
4XS2
4Y73
4YO6
4YP8
4ZTL
4ZTM
4ZTN
5K72
5K75
5K76
5K7G
5K7I
5KX7
5KX8
5T1S
5T1T
5UIQ
5UIR
5UIS
5UIT
5UIU
5W84
5W85
6EG9
6EGA
6EGD
6EGE
6EGF
6F3D
6F3E
6F3G
6F3I
6LXY
6MOM
6N8G
6O8U
6O94
6O95
6O9D
6RFI
6RFJ
6THW
6THX
6THZ
6TI8
6TIA
6UYA
6VQL
7C2V
7C2W
7QG1
7QG2
7QG3
7QG5
8ATB
8ATL
8ATN
8BR5
8BR6
8BR7
8DKS
8SCE
8SCV
8SCW
8TVM
8TVN
8TX0
8UCB
8UCC
8V1O
8V2F
8V2L
8W3W
8W3X
8WTF
1X0O
2A24
2B02
2HV1
2K7S
3F1N
3F1O
3F1P
3H7W
3H82
4EQ1
4GHI
4GS9
4H6J
4LPZ
4PKY
4XT2
5TBM
5UFP
5V0L
6CZW
6D09
6D0B
6D0C
6X21
6X28
6X2H
6X37
6X3D
8CK3
8CK4
8CK8
8G4A
8XS6
8XS7
8XS8
8XS9
8XSA
8XSB
Enriched GO Terms of Interacting Partners
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Chromosome Condensation
Nucleosomal DNA Binding
Negative Regulation Of DNA Recombination
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of DNA Recombination
Chromatin DNA Binding
Structural Constituent Of Chromatin
Toll-like Receptor 4 Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Nucleosome Assembly
Cell Surface Pattern Recognition Receptor Signaling Pathway
Nucleosome
Euchromatin
Nucleosome Organization
Double-stranded DNA Binding
Negative Regulation Of DNA Metabolic Process
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Regulation Of Toll Signaling Pathway
Signaling Adaptor Activity
Regulation Of Macromolecule Metabolic Process
Innate Immune Response
Response To Lipopolysaccharide
Interleukin-33-mediated Signaling Pathway
Regulation Of Toll-like Receptor 4 Signaling Pathway
Protein-DNA Complex Assembly
Cellular Response To Molecule Of Bacterial Origin
Response To Molecule Of Bacterial Origin
Positive Regulation Of Cytokine Production
Defense Response To Symbiont
Defense Response To Other Organism
Regulation Of Metabolic Process
Regulation Of Cytokine Production
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Type I Interferon Production
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Ubiquitin-ubiquitin Ligase Activity
Immune Response
Positive Regulation Of Gene Expression
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Interleukin-6 Production
Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Positive Regulation Of Chemokine Production
Regulation Of DNA Metabolic Process
Response To External Biotic Stimulus
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Positive Regulation Of DNA-templated Transcription
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Protein Dimerization Activity
Regulation Of RNA Metabolic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin
Positive Regulation Of Metabolic Process
Transcription Regulator Complex
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Cell Population Proliferation
Regulation Of Macromolecule Biosynthetic Process
Intracellular Signal Transduction
Regulation Of Gene Expression
Rhythmic Process
Developmental Process
Cytoplasm
Cell Differentiation
Regulation Of Cell Cycle
Signal Transduction
Animal Organ Development
Transcription By RNA Polymerase II
Regulation Of Apoptotic Process
Positive Regulation Of Cell Population Proliferation
DNA-templated Transcription
Regulation Of Programmed Cell Death
DNA Binding
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Signal Transduction
Intracellular Receptor Signaling Pathway
Cytosol
DNA-binding Transcription Factor Activity
Regulation Of Intracellular Signal Transduction
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cellular Developmental Process
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