PELI2 and LTBP3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PELI2	LTBP3
Gene Name		pellino E3 ubiquitin protein ligase family member 2	latent transforming growth factor beta binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Extracellular Region Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Ligase Activity	Calcium Ion Binding Transforming Growth Factor Beta Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll Signaling Pathway Protein Ubiquitination Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response	Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Transforming Growth Factor Beta Activation Positive Regulation Of Bone Resorption Bone Remodeling Bone Morphogenesis Lung Saccule Development Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Interleukin-1 signaling Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK1 recruits IKK complex Innate Immune System	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Telomere length ( 21460395)	Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Urate levels ( 23263486)
Protein-Protein Interactions		17 interactors: BCL10 CREB3L3 DEAF1 ERO1L FN1 FRYL HNRNPK IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 MYD88 PICALM SRPK1 THAP7 UBQLN4	12 interactors: CACNA1A CCNG1 GORASP2 HBEGF ITGB5 PELI2 PIK3R2 PRPF40A RAC1 TGFB1 TGFB2 TGFB3
Entrez ID		57161	4054
HPRD ID		17835	03649
Ensembl ID		ENSG00000139946	ENSG00000168056
Uniprot IDs		Q9H716 Q9HAT8	B9EG76 Q8WYU6 Q9NS15
PDB IDs		3EGA 3EGB
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway JNK Cascade Regulation Of Innate Immune Response Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Signaling Pathway MAPK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Interleukin-1 Response To Peptidoglycan Regulation Of RNA Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Interleukin-1-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cytokine Biosynthetic Process Positive Regulation Of Peptidase Activity	Negative Regulation Of Macrophage Cytokine Production Cellular Response To Growth Factor Stimulus Response To Growth Factor SMAD Protein Import Into Nucleus Cell Growth Regulation Of Cell Morphogenesis Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Wound Healing Uterine Wall Breakdown Tissue Remodeling Response To Wounding Positive Regulation Of Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Signaling Pathway Face Morphogenesis Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Cell Morphogenesis Involved In Differentiation Head Morphogenesis Head Development Positive Regulation Of Intracellular Signal Transduction Blood Coagulation Ossification Involved In Bone Remodeling Hemostasis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Migration Salivary Gland Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Salivary Gland Development Cell Surface Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Response To Transforming Growth Factor Beta Platelet Activation Frontal Suture Morphogenesis Response To Progesterone Regulation Of Phosphorus Metabolic Process Face Development Cell Motility Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Growth SMAD Protein Signal Transduction Negative Regulation Of Cytokine Production Regulation Of Epithelial To Mesenchymal Transition Cell-cell Junction Organization Regulation Of Lipid Kinase Activity Bone Remodeling Exocrine System Development Body Morphogenesis
Tagcloud ?			albeit causal contributor correlates define differ differing doi dx ecm egln1 elife http identifies mammary matrix metastatic org proteomics s100a2 serve signatures sned1 steps stroma stromal tgfbeta tools xenografts
Tagcloud (Difference) ?			albeit causal contributor correlates define differ differing doi dx ecm egln1 elife http identifies mammary matrix metastatic org proteomics s100a2 serve signatures sned1 steps stroma stromal tgfbeta tools xenografts
Tagcloud (Intersection) ?