PELI2 and PRR36

Number of citations of the paper that reports this interaction (PubMedID 34674267)
0

Data Source:
BioGRID (two hybrid)

		PELI2	PRR36
Description		pellino E3 ubiquitin protein ligase family member 2	proline rich 36
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol
	Molecular Function	Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)	Low density lipoprotein cholesterol levels ( 33339817) Total cholesterol levels ( 33339817)
Interacting Genes		44 interacting genes: BCL10 CEP170B CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 IRS1 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MPDZ MYD88 MYO10 NEK9 NUP62 OR7D2 PCGF2 PICALM PRR36 RABEP1 RBBP8 REL RMDN3 RNF220 SEPTIN3 SP4 SRPK1 TGM2 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4 YTHDF2	2 interacting genes: NPSR1 PELI2
Entrez ID		57161	80164
HPRD ID		17835	18916
Ensembl ID		ENSG00000139946	ENSG00000183248
Uniprot IDs		Q9H716 Q9HAT8	Q9H6K5
PDB IDs		3EGA 3EGB
Enriched GO Terms of Interacting Partners?		Toll Signaling Pathway Non-canonical NF-kappaB Signal Transduction Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process General Transcription Initiation Factor Binding Positive Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response-activating Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Activation Of Innate Immune Response Positive Regulation Of Defense Response Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Endolysosomal Toll-like Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Adaptor Activity Anatomical Structure Morphogenesis Regulation Of Apoptotic Signaling Pathway Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Defense Response Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Response To Stress Regulation Of Cell Communication Cellular Developmental Process Regulation Of Signaling Regulation Of Gene Expression Positive Regulation Of DNA-binding Transcription Factor Activity	Negative Regulation Of Defecation Regulation Of Toll Signaling Pathway Positive Regulation Of MAPK Cascade Righting Reflex Negative Regulation Of Feeding Behavior Regulation Of Eating Behavior Negative Regulation Of Eating Behavior Vasopressin Receptor Activity Regulation Of MAPK Cascade Ubiquitin-ubiquitin Ligase Activity Reflex Neuropeptide Receptor Activity Regulation Of Feeding Behavior Eating Behavior Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Signal Transduction Regulation Of Behavior Feeding Behavior Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Neuropeptide Signaling Pathway Positive Regulation Of Calcium Ion Transport Regulation Of Intracellular Signal Transduction Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport
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